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Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections Electron. J. Biotechnol.
Vilos,Cristian; Constandil,Luis; Herrera,Natalia; Solar,Paula; Escobar-Fica,Jorge; Velásquez,Luis Alberto.
Background: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The...
Tipo: Journal article Palavras-chave: Ceftiofur; Drug delivery; Livestock breeding industry; PHBV; Polymeric microparticles.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000400001
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The posthatch prophylactic use of ceftiofur affects the cecalmicrobiota similar to the dietary sanguinarine supplementationin broilers. Repositório Alice
LEMOS, M. P. L.; SARAIVA, M. M. S.; LEITE, E. L.; SILVA, N. M. V.; VASCONCELOS, P. C.; GIACHETTO, P. F.; FREITAS NETO, O. C.; GIVISIEZ, P. E. N.; GEBREYES, W. A.; OLIVEIRA, C. J. B..
Abstract. The prophylactic administration of ceftiofur to newly hatched chicks is a common practice in some hatcheries worldwide to mitigate early gastrointestinal infections caused by Enterobacteriaceae. In spite of the crucial role of the gut microbiome for the broiler's health, there is still limited information on how the microbial composition is affected by such procedure. We investigated the effects of posthatch prophylactic application of ceftiofur on the cecal microbiota of 14-day-old broilers fed regular or sanguinarine-supplemented diets. DNA samples were extracted from cecal contents, amplified for the V3-V4 regions of the microbial 16S rRNA gene, and sequenced in a high-throughput sequencing platform (Illumina MiSeq). After downstream...
Tipo: Artigo de periódico Palavras-chave: Bioinformática; Aplicação profilática pós-parto; Broiler; Cecal microbiota; 16S rRNA; Frango; Frango de Corte; Análise Estatística; Broiler chickens; Bioinformatics; Statistical analysis; Ceftiofur; Sanguinarine.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1126346
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