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Registros recuperados: 37
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A rare retrobulbar and chiasmal meningioma in a dog Ciência Rural
Aiello,Graciane; Ripplinger,Angel; Schwab,Marcelo Luís; Ferrarin,Dênis Antonio; Rauber,Júlia da Silva; Areco,Walter Cardozo; Flores,Mariana Martins; Mazzanti,Alexandre.
ABSTRACT: A 14-year-old female Dachshund was referred to a veterinary hospital with a history and signalment of head pressing, compulsive walking, and right circling. At ophthalmologic examination, a mature cataract and absence of photomotor reflex in the right eye were observed. The neurological exam revealed multifocal encephalic signs. At necropsy, a conical solid tan mass was observed involving the right optic nerve throughout its extension to the optic chiasm. Histopathological findings confirmed a retrobulbar papillary meningioma, considered rare and seldom included as differential diagnosis in patients with neurological signs.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ocular neoplasm; Papillary meningioma; Central nervous system; Canine.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000700551
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Analysis of trophic responses in lesioned brain: focus on basic fibroblast growth factor mechanisms BJMBR
Chadi,G.; Fuxe,K..
The actions of fibroblast growth factors (FGFs), particularly the basic form (bFGF), have been described in a large number of cells and include mitogenicity, angiogenicity and wound repair. The present review discusses the presence of the bFGF protein and messenger RNA as well as the presence of the FGF receptor messenger RNA in the rodent brain by means of semiquantitative radioactive in situ hybridization in combination with immunohistochemistry. Chemical and mechanical injuries to the brain trigger a reduction in neurotransmitter synthesis and neuronal death which are accompanied by astroglial reaction. The altered synthesis of bFGF following brain lesions or stimulation was analyzed. Lesions of the central nervous system trigger bFGF gene expression by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Radioautography; In situ hybridization; Basic fibroblast growth factor; FGF receptor; Astrocyte; Image analysis; Central nervous system; Brain lesion.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000200007
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Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions BJMBR
Johnson,R.A.; Kozma,F.; Colombari,E..
Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally arises from heme degradation in a reaction catalyzed by heme oxygenase. While inhibitors of endogenous CO production can raise arterial pressure, heme loading can enhance CO production and lead to vasodepression. Both central and peripheral tissues possess heme oxygenases and generate CO from heme, but the inability of heme substrate to cross the blood brain barrier suggests the CNS heme-heme oxygenase-CO system may be independent of the periphery. In the CNS, CO apparently acts in the nucleus tractus solitarii (NTS) promoting changes in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbon monoxide; Heme; Heme oxygenase; Blood pressure; Central nervous system; Vascular tone.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100001
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Caspase dependence of the death of neonatal retinal ganglion cells induced by axon damage and induction of autophagy as a survival mechanism BJMBR
Sternberg,C.; Benchimol,M.; Linden,R..
We examined the degeneration of post-mitotic ganglion cells in ex-vivo neonatal retinal explants following axon damage. Ultrastructural features of both apoptosis and autophagy were detected. Degenerating cells reacted with antibodies specific for activated caspase-3 or -9, consistent with the presence of caspase activity. Furthermore, peptidic inhibitors of caspase-9, -6 or -3 prevented cell death (100 µM Ac-LEDH-CHO, 50 µM Ac-VEID-CHO and 10 µM Z-DEVD-fmk, respectively). Interestingly, inhibition of autophagy by 7-10 mM 3-methyl-adenine increased the rate of cell death. Immunohistochemistry data, caspase activation and caspase inhibition data suggest that axotomy of neonatal retinal ganglion cells triggers the intrinsic apoptotic pathway, which, in turn,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Autophagy; Caspases; Retina; Central nervous system.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000005
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Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus in a patient with AIDS: case report and review of the literature BJID
Corti,Marcelo; Fioti,María F. Villafañe; Yampolsky,Claudio; Schtirbu,Ricardo; Narbaitz,Marina.
Intracranial and intraspinal involvement is a rare complication of Hodgkin's disease. We report a case of a patient with diagnosis of AIDS and Hodgkin's lymphoma who developed brain and spinal involvement at the time of the relapse of the neoplasm disease. Mixed cellularity histology was the subtype of Hodgkin's disease in our patient; we identified the Epstein-Barr virus genome in the Reed-Sternberg cells by immunohistochemistry and in situ hybridization.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Hodgkin lymphoma; Central nervous system; AIDS.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600009
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Consequences of cerebroventricular insulin injection on renal sodium handling in rats: effect of inhibition of central nitric oxide synthase BJMBR
Oliveira,P.C.; Michelotto,J.B.; Zapparoli,A.; Boer,P.A.; Gontijo,J.A.R..
In the present study, we investigated the effects of acute intracerebroventricular (icv) insulin administration on central mechanisms regulating urinary sodium excretion in simultaneously centrally NG-nitro-L-arginine methylester (L-NAME)-injected unanesthetized rats. Male Wistar-Hannover rats were randomly assigned to one of five groups: a) icv 0.15 M NaCl-injected rats (control, N = 10), b) icv dose-response (1.26, 12.6 and 126 ng/3 µL) insulin-injected rats (N = 10), c) rats icv injected with 60 µg L-NAME in combination with NaCl (N = 10) or d) with insulin (N = 10), and e) subcutaneously insulin-injected rats (N = 5). Centrally administered insulin produced an increase in urinary output of sodium (NaCl: 855.6 ± 85.1 Δ%/min; 126 ng insulin: 2055 ± 310.6...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central nervous system; Intracerebroventricular; Nitric oxide inhibition; Insulin; Natriuresis; Lithium clearance.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200013
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Cranial cavity filled with cerebrospinal fluid in an otter (Lontra longicaudis) - case report Arq. Bras. Med. Vet. Zootec.
Costa,L.V.L.; Bonelli,M.A.; Silva,I.C.C.; Santos,M.S.; Fernandes,T.H.T.; Schwarz,T.; Costa,F.S..
ABSTRACT Computed tomography of the head of an otter with a history of incoordination, visual deficits, and seizures was performed. Intracranial images revealed a large non-enhancing fluid attenuating cystic lesion in the left frontoparietal region communicating with the left lateral ventricle and subarachnoid space. These findings are consistent with a congenital brain cavity filled by cerebrospinal fluid, with porencephaly being the most probable diagnosis based on the clinical and tomographic findings. The authors highlight the rarity of such a cystic lesion in wild animals, with this being the first report in otters.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central nervous system; Poroencephaly; Computed tomography; Congenital disorder; Wild animals.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601861
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Delayed Schwann cell and oligodendrocyte remyelination after ethidium bromide injection in the brainstem of Wistar rats submitted to streptozotocin diabetogenic treatment BJMBR
Bondan,E.F.; Lallo,M.A.; Trigueiro,A.H.; Ribeiro,C.P.; Sinhorini,I.L.; Graça,D.L..
Schwann cell disturbance followed by segmental demyelination in the peripheral nervous system occurs in diabetic patients. Since Schwann cell and oligodendrocyte remyelination in the central nervous system is a well-known event in the ethidium bromide (EB) demyelinating model, the aim of this investigation was to determine the behavior of both cell types after local EB injection into the brainstem of streptozotocin diabetic rats. Adult male Wistar rats received a single intravenous injection of streptozotocin (50 mg/kg) and were submitted 10 days later to a single injection of 10 µL 0.1% (w/v) EB or 0.9% saline solution into the cisterna pontis. Ten microliters of 0.1% EB was also injected into non-diabetic rats. The animals were anesthetized and perfused...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central nervous system; Diabetes mellitus; Ethidium bromide; Remyelination; Schwann cell; Oligodendrocyte.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500011
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Dextran Sulphate of Sodium-induced colitis in mice: antihyperalgesic effects of ethanolic extract of Citrus reticulata and potential damage to the central nervous system Anais da ABC (AABC)
HILEL,ALEXANDRE S.; GYSEMANS,BRUNA; LISBÔA,MARIA E.M.; HEYMANNS,ANA C.; FREIBERGER,VIVIANE; VENTURA,LETÍCIA; MAGNAGO,RACHEL F.; COMIM,CLARISSA M.; HOREWICS,VERÔNICA; MARTINS,DANIEL F.; BOBINSKI,FRANCIANE; PIOVEZAN,ANNA P..
Abstract Citrus species are widely related to antihyperalgesic and anti-inflammatory effects. The aim of this study was to investigate if treatment with ethanolic extract from peels of mature Citrus reticulata Blanco causes antihyperalgesic effects on the referred mechanical hyperalgesia in a model of dextran sulphate of sodium (DSS)-induced colitis in mice, as well as the possible oxidative damage in different regions of the brain induced by its inflammatory reaction. Antihyperalgesia (30 to 300 mg/kg) was investigated by behavioral response (frequency of response to von Frey filament stimulation) in Swiss mice, while damage to central nervous system was investigated through techniques that evaluated oxidative stress using male black C57 BL6 mice (n=8)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Citrus reticulate; Medicinal plants; Inflammation; Oxidative stress; Central nervous system.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603139
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Differential patterns of myosin Va expression during the ontogenesis of the rat hippocampus BJMBR
Brinn,L.S.; Pereira Leite,J.; Larson,R.E.; Martins,A.R..
Myosin Va is an actin-based, processive molecular motor protein highly enriched in the nervous tissue of vertebrates. It has been associated with processes of cellular motility, which include organelle transport and neurite outgrowth. The in vivo expression of myosin Va protein in the developing nervous system of mammals has not yet been reported. We describe here the immunolocalization of myosin Va in the developing rat hippocampus. Coronal sections of the embryonic and postnatal rat hippocampus were probed with an affinity-purified, polyclonal anti-myosin Va antibody. Myosin Va was localized in the cytoplasm of granule cells in the dentate gyrus and of pyramidal cells in Ammon's horn formation. Myosin Va expression changed during development, being...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myosin Va; Growth and development; Central nervous system; Hippocampus; Rat; Immunohistochemistry.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000900012
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Effect of intracerebroventricularly injected insulin on urinary sodium excretion by cerebroventricular streptozotocin-treated rats BJMBR
Macedo,R.F.; Furlan,F.C.; Marshall,P.S.; Michelotto,J.B.; Gontijo,J.A.R..
Recent evidence suggests that insulin may influence many brain functions. It is known that intracerebroventricular (icv) injection of nondiabetogenic doses of streptozotocin (STZ) can damage insulin receptor signal transduction. In the present study, we examined the functional damage to the brain insulin receptors on central mechanisms regulating glomerular filtration rate and urinary sodium excretion, over four periods of 30 min, in response to 3 µl insulin or 0.15 NaCl (vehicle) injected icv in STZ-treated freely moving Wistar-Hannover rats (250-300 g). The icv cannula site was visually confirmed by 2% Evans blue infusion. Centrally administered insulin (42.0 ng/µl) increased the urinary output of sodium (from 855.6 ± 85.1 to 2055 ± 310.6 delta%/min; N =...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Central nervous system; Insulin; Natriuresis; Streptozotocin; Lithium clearance.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900008
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Effects of Brazilian scorpion venoms on the central nervous system J. Venom. Anim. Toxins incl. Trop. Dis.
Nencioni,Ana Leonor Abrahão; Beraldo Neto,Emidio; Freitas,Lucas Alves de; Dorce,Valquiria Abrão Coronado.
Abstract In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. costatus, T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system. On the other hand, some evidence show the participation of the central nervous system and inflammatory response in the process....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazilian scorpions; Central nervous system; Scorpion venom; Scorpion toxins.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100202
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Ethanol Intake and Toxicity: In Search of New Treatments International Journal of Morphology
Sandoval,Cristian; Vásquez,Bélgica; Mandarim-de-Lacerda,Carlos; del Sol,Mariano.
Prolonged alcohol consumption has consequences on the liver, producing necrotic precipitates and fibrosis, on the pancreas, causing the pancreatic acini to atrophy and destroying insulin-producing cells, and on the central nervous system (CNS), causing the gray and white matter in the frontal lobes of the brain and cerebellum to atrophy. Generally, alcohol is metabolized via oxidative pathways, where the enzymes alcohol dehydrogenase and aldehyde dehydrogenase participate during its metabolization in the liver and CNS, or via non-oxidative pathways during its metabolization in the pancreas. Ethanol metabolism can produce oxidative stress and tissue damage mediated by free radicals, causing morphological and functional alterations in the liver. In the...
Tipo: Journal article Palavras-chave: Antioxidants; Ethanol; Liver; Pancreas; Central nervous system.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300024
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Expression of extracellular matrix components and their receptors in the central nervous system during experimental Toxoplasma gondii and Trypanosoma cruzi infection BJMBR
Silva,A.A.; Roffê,E.; Lannes-Vieira,J..
Alterations in extracellular matrix (ECM) expression in the central nervous system (CNS) usually associated with inflammatory lesions have been described in several pathological situations including neuroblastoma and demyelinating diseases. The participation of fibronectin (FN) and its receptor, the VLA-4 molecule, in the migration of inflammatory cells into the CNS has been proposed. In Trypanosoma cruzi infection encephalitis occurs during the acute phase, whereas in Toxoplasma infection encephalitis is a chronic persisting process. In immunocompromised individuals such as AIDS patients, T. cruzi or T. gondii infection can lead to severe CNS damage. At the moment, there are no data available regarding the molecules involved in the entrance of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Toxoplasma gondii; Trypanosoma cruzi; Central nervous system; Extracellular matrix.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500013
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Fever induction pathways: evidence from responses to systemic or local cytokine formation BJMBR
Roth,J.; de Souza,G.E.P..
The immune and central nervous systems are functionally connected and interacting. The concept that the immune signaling to the brain which induces fever during infection and inflammation is mediated by circulating cytokines has been traditionally accepted. Administration of bacterial lipopolysaccharide (LPS) induces the appearance of a so-termed "cytokine cascade" in the circulation more or less concomitantly to the developing febrile response. Also, LPS-like fever can be induced by systemic administration of key cytokines (IL-1ß, TNF-alpha, and others). However, anti-cytokine strategies against IL-1ß or TNF-alpha along with systemic injections of LPS frequently lead to attenuation of the later stages of the febrile response but not of the initial phase...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fever; Cytokines; Neuroimmunomodulation; Humoral factors; Afferent nerves; Central nervous system.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300003
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Gross brain morphology of Rhamdia quelen (Quoy & Gaimard 1824) (Ostariophysi: Siluriformes: Heptapteridae) Pap. Avulsos de Zool. (São Paulo)
Abrahão,Vitor Pimenta; Pupo,Fábio Müller dos Reis de Salles; Shibatta,Oscar Akio.
Abstract The brain gross morphology of Rhamdia quelen is described and compared with seven species of six genera of Heptapteridae. Interspecific variation in shape, size, and position of brain subdivisions was observed in all examined species. The posterior position of the hypophysis on the hypothalamus and presence of a lateral subdivision on the lobus facialis are shared by all examined heptapterids. Rhamdia quelen and Pimelodella gracilis, currently considered closely related within the family Heptapteridae, exhibit the anterior and posterior area of the telencephalon with equivalent widths, and the lateral line lobe reaching the anterior area of the lobus vagi. Members of the so called Nemuroglanis sub-clade (Cetopsorhamdia iheringi, Heptapterus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central nervous system; Anatomy; Catfish; Neotropical region.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0031-10492018000100240
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Halicephalobus gingivalis (H.deletrix) in the brain of a horse Ciência Rural
Vasconcelos,Rosemeri de Oliveira; Lemos,Karen Regina; Moraes,Julieta Rodini Engracia de; Borges,Vívian Palmeira.
A 10-year-old Mangalarga gelding with rhabditiform nematode infection in the brain is described. Clinical signs were limited to circling and right side paralysis. Histological examination of the brain revealed marked gliosis and discreet edema. The perivascular mononuclear inflammatory infiltrate was composed of few layers of lymphocytes, plasmocytes and macrophages and rare eosinophils. The presence of rhabditiform nematodes was associated with the infiltrate. Areas of malacia associated with the parasites and parasite tracks with axonal spheroids were also seen close to the vessels and to the etiological agent and were more evident in the white matter. In the meninges there was moderate inflammatory infiltrate associated with perivascular parasites. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nematode; Equine; Central nervous system; Micronema deletrix.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000400047
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Human immunodeficiency virus and the central nervous system BJID
Almeida,Sergio Monteiro de; Letendre,Scott; Ellis,Ron.
The pandemic of HIV/AIDS continues to grow daily. Incident cases among women, intravenous drug users and ethnic minorities comprise the fastest growing segment of the HIV-infected population, and the number of HIV-infected individuals over the age of 50 is growing rapidly. Today, the central nervous system and the immune system are seen as main targets of HIV infection. Significant progress in the knowledge and treatment of AIDS has been obtained in recent years. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system.
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; AIDS; HIV dementia; Central nervous system; Cerebrospinal fluid; Viral load; Chemokines.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100009
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Inflammatory response of the spinal cord to multiple episodes of blood-brain barrier disruption and toxic demyelination in Wistar rats BJMBR
Fernandes,C.G.; Graça,D.L.; Pereira,L.A.V.D..
Multiple episodes of blood-brain barrier disruption were induced by sequential intraspinal injections of ethidium bromide. In addition to the barrier disruption, there was toxic demyelination and exposure of myelin components to the immune system. Twenty-seven 3-month-old Wistar rats received 2, 3 or 4 injections of 1 µl of either 0.1% ethidium bromide in normal saline (19 rats) or 0.9% saline (8 rats) at different levels of the spinal cord. The time intervals between the injections ranged from 28 to 42 days. Ten days after the last injection, all rats were perfused with 2.5% glutaraldehyde. The spinal sections were evaluated macroscopically and by light and transmission electron microscopy. All the lesions demonstrated a mononuclear phagocytic infiltrate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lymphocytes; Multiple sclerosis; Central nervous system; Blood-brain barrier; Ethidium bromide.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700008
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Leukoencephalomalacia in horses associated with immature corn consumption Ciência Rural
Echenique,Joanna Vargas Zillig; Estima-Silva,Pablo; Pereira,Daniela Brayer; Marques,Lucas Santos; Ribeiro,Luiza Soares; Schild,Ana Lucia.
ABSTRACT: Horse leukoencephalomalacia (ELEM) is a disease caused by the ingestion of mycotoxins (fumonisins) produced by fungi of the genus Fusarium that infect corn and/or its byproducts. This disease has been described by ingestion of mature corn with humidity above 15% at temperatures below 20°C. The aim of this paper was to report an outbreak of leukoencephalomalacia in horses fed with immature corn. Two horses out of three showed neurological signs approximately seven days after eating immature corn in its reproductive phase (R2, milky grains). Corn was harvested and administered directly to the animals, with no storage. Deaths occurred approximately 24 hours after the onset of clinical signs. Grossly, there were multifocal dark red to brown areas in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fumonisin; Water activity; Cereals; Central nervous system; Horse..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000300551
Registros recuperados: 37
Primeira ... 12 ... Última
 

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