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Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts Anais da ABC (AABC)
PINTO,NÍCOLAS C.C.; SILVA,JUCÉLIA B.; MENEGATI,LAURA M.; GUEDES,MARIA CLARA M.R.; MARQUES,LUCAS B.; SILVA,THIAGO P. DA; MELO,ROSSANA C.N. DE; SOUZA-FAGUNDES,ELAINE M. DE; SALVADOR,MARCOS J.; SCIO,ELITA; FABRI,RODRIGO L..
ABSTRACT This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were used. ASL showed significant antibacterial activity against S. aureus, K. pneumoniae and E. faecalis with MIC values of 78, 78 and 39 µg/mL respectively. Moreover, ASL exhibited significant biofilm disruption, rapid time dependent kinetics of bacterial killing, increased membrane permeability and significantly reduced the cell numbers and viability. Regarding the cytotoxicity against tumor cell lines, ASS was more active against Jurkat and MCF-7 cells, with CI50 1.1 and 2.1 µg/mL, respectively. ASL showed promising activity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alkaloids; Annona squamosa; Antibacterial; Citotoxicity; Herbal medicine.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502053
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Physicochemical characterization and evaluation of in vitro and in vivo toxicity of goldenberry extract nanoemulsion Ciência Rural
Silva,Suelen Santos da; Bazana,Maiara Taís; Deus,Cassandra de; Machado,Marina Lopes; Cordeiro,Larissa Marafiga; Soares,Félix Alexandre Antunes; Libreloto,Daniele Rubert Nogueira; Rolim,Clarice Madalena Bueno; Menezes,Cristiano Ragagnin de; Codevilla,Cristiane Franco.
ABSTRACT: Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and non-tumor cell lines, and in vivo using Caenorhabditis elegans. The pH of the nanoemulsion was 3.84, the mean droplet diameter was 268 ± 7 nm, PDI 0.113 and zeta potential -13.94 mV. Results of the cytotoxicity assays employing non-tumor cells indicated that the extract associated or not with nanoemulsion maintained cell viability at different concentrations tested. In the assays using tumor lineage,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Physalis peruviana; Nanoemulsion; Citotoxicity; C. elegans..
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000800754
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Preservation of cytotoxic granule production in response to mycobacterial antigens by T-lymphocytes from vertically HIV-infected Brazilian youth on effective combined antiretroviral therapy BJID
Arrym,Mauro Pedromonico; Alves,Paulo César Martins; Castelhano,Mariana Virginello; Mazzola,Taís Nitsch; Lemos,Renata Muller Banzato Pinto de; Zaccariotto,Tânia Regina; Levy,Carlos Emilio; Guimarães,Fernando; Silva,Marcos Tadeu Nolasco da.
ABSTRACT Background: HIV infection harms adaptive cellular immunity mechanisms. Long-term virological control by combined antiretroviral therapy (cART) reduces the risk of mycobacterial infections. Thus, we aimed to study cellular responses to mycobacterial antigens in 20 HIV-infected adolescents with at least one year of virological control (HIV-RNA <40 copies/mL) and 20 healthy adolescents. Methods: We evaluated CD8 and γδ T-cell degranulation by measurement of CD107a membrane expression after stimulation with lysates from BCG (10 µg/mL) and H37RA Mycobacterium tuberculosis (Mtb, 10 µg/mL). Immune activation and antigen-presenting ability were also assessed by determination of HLA-DR, CD80, and CD86 markers. Results: TCR γδ T-cell CD107a expression...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV/Aids; BCG; Youth; Tuberculosis; Citotoxicity; Immunologic.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300151
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