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Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system BJPS
Haseeb,Muhammad Tahir; Bashir,Sajid; Hussain,Muhammad Ajaz; Ashraf,Muhammad Umer; Erum,Alia; Naeem-ul-Hassan,Muhammad.
ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Linseed hydrogel; Acute toxicity; Hematology; Clinical biochemistry; Polysaccharide.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200610
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Interference of Salmonella typhimurium lipopolysaccharide on performance and biological parameters of broiler chickens Rev. Bras. Ciênc. Avic.
Rauber,RH; Perlin,VJ; Fin,CD; Mallmann,AL; Miranda,DP; Giacomini,LZ; Nascimento,VP do.
This study was conducted to determine the interference of Salmonella typhimurium lipopolysaccharide (sLPS) on the performance, biological parameters, and histological evaluations of 198 one-day-old male broiler chickens divided into three treatments according to sLPS dose (0, 250, or 500 µg/application/bird) that was applied to the birds every other day, from 15 to 27 days of age. At the end of the experiment (28 days), significant effects were observed on body weight (R= -0.17 and P=0.05), total cholesterol serum levels(R=0.43 and p<0.01), phosphorus (R=0.53 and P<0.01), uric acid (R= -0.38 and P<0.01), C-reactive protein (R=0.68 and p<0.01), serum activity of aspartate aminotransferase (R=0.39 and p<0.01) and alkaline phosphatase (R= -0.39...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Poultry; Clinical biochemistry; Endotoxin; Body weight.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2014000100011
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Metabolic dynamics of native lambs fed with Tifton 85 hay or Maniçoba hay associated with the spineless cactus Arq. Bras. Med. Vet. Zootec.
Soares,P.C.; Gouveia,L.N.F.; Silva,T.G.P.; O. Filho,E.F.; Carvalho,F.F.R.; Batista,Â.M.V.; Lima Júnior,D.M.; Cardoso,D.B..
ABSTRACT The objective of this study was to evaluate the metabolic response of native lambs fed Tifton 85 hay (Cynodon dactylon) or Maniçoba hay (Manihot pseudoglaziovii) associated with spineless cactus (Nopalea cochenillifera Salm Dyck). Sixteen Morada Nova lambs were used, with a mean initial weight of 19.36±1.48kg, distributed in a randomized block design, with two treatments and eight replications. Dry matter intake was higher for lambs fed Maniçoba hay compared to Tifton hay, while the body weight at slaughter was not influenced by diets. Regarding the blood metabolites, only the serum concentration of urea was influenced, with higher value observed in the lambs that fed the diet containing Tifton hay. When analyzing blood biomarkers, in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood biomarkers; Clinical biochemistry; Metabolism; Native breeds; Nutrition; Small ruminants.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352020000100215
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Serum γ-glutamyltransferase activity as an indicator of chronic liver injury in cattle with no clinical signs Arq. Bras. Med. Vet. Zootec.
Moreira,C.N.; Souza,S.N.; Barini,A.C.; Araújo,E.G.; Fioravanti,M.C.S..
This study aimed to determine the power of the serum aspartate aminotransferase (AST) and gamma-glutamyltransferasase (GGT) activities and of the albumin and cholesterol dosages for detecting hepatic histopathological injuries. A total of 220 healthy male Nelore cattle that had been extensively bred were evaluated. Blood and liver samples were collected on the day of slaughter for biochemical and histopathological tests. The results showed that the sensitivity to AST, GGT, albumin, and cholesterol tests were respectively 22.4%, 22.4%, 36%, and 37.2%. The specificity of AST, GGT, albumin, and cholesterol tests was respectively 78.8%, 90.4%, 75.6%, and 68.3%. In short, the detection of minor liver injuries through biochemical tests is limited; however, the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beef cattle; Albumin; AST; Cholesterol; Clinical biochemistry; GGT.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000600001
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