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Lead reduces tension development and the myosin ATPase activity of the rat right ventricular myocardium 56
Vassallo,D.V.; Lebarch,E.C.; Moreira,C.M.; Wiggers,G.A.; Stefanon,I..
Lead (Pb2+) poisoning causes hypertension, but little is known regarding its acute effects on cardiac contractility. To evaluate these effects, force was measured in right ventricular strips that were contracting isometrically in 45 male Wistar rats (250-300 g) before and after the addition of increasing concentrations of lead acetate (3, 7, 10, 30, 70, 100, and 300 µM) to the bath. Changes in rate of stimulation (0.1-1.5 Hz), relative potentiation after pauses of 15, 30, and 60 s, effect of Ca2+ concentration (0.62, 1.25, and 2.5 mM), and the effect of isoproterenol (20 ng/mL) were determined before and after the addition of 100 µM Pb2+. Effects on contractile proteins were evaluated after caffeine treatment using tetanic stimulation (10 Hz) and measuring...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lead; Right ventricular strips; Contraction; Heart; Myosin ATPase activity.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900008
Registros recuperados: 1
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