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AN in vivo METHOD FOR ESTIMATING THE CONCENTRATION OF CROTAMINE IN A SOLUTION J. Venom. Anim. Toxins
HAMPE,O. G.; BELLÓ,A. A..
very sensitive method for estimating the concentration of crotamine in a solution was developed. This method was based on the time required for the appearance of permanent hyperextension of the rear legs of mice as a function of the dose administered. This method can be used to determine toxin doses as low as 0.32 mg/kg<img SRC="http:/img/fbpe/jvat/v3n1/image2875.gif"> . Its high specificity for crotamine means that it can be used to measure toxin concentrations in the presence of other proteins and polypeptides.
Tipo: Info:eu-repo/semantics/other Palavras-chave: Crotalus durissus terrificus venom; Crotamine; Method to estimate the concentration.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000100004
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Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine J. Venom. Anim. Toxins incl. Trop. Dis.
Teixeira-Araújo,Ricardo; Castanheira,Patrícia; Brazil-Más,Leonora; Pontes,Francisco; Araújo,Moema Leitão de; Alves,Maria Lucia Machado; Zingali,Russolina Benedeta; Correa-Netto,Carlos.
Abstract Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA. However, each institution uses its own mixture of rattlesnake venom antigens. Previous works have shown that crotamine, a toxin found in Crolatus durissus venom, shows marked individual and populational variation. In addition, serum produced from...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Antivenom production; Antivenomics; Crotalus durissus; Crotamine; Crotoxin; Geographic venom variation.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100602
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Effects of 60Co gamma radiation on crotamine BJMBR
Boni-Mitake,M.; Costa,H.; Spencer,P.J.; Vassilieff,V.S.; Rogero,J.R..
Ionizing radiation can change the molecular structure and affect the biological properties of biomolecules. This has been employed to attenuate animal toxins. Crotamine is a strongly basic polypeptide (pI 10.3) from Crotalus durissus terrificus venom composed of 42 amino acid residues. It induces skeletal muscle spasms leading to a spastic paralysis of hind limbs in mice. The objective of the present study was to carry out a biochemical study and a toxic activity assay on native and irradiated crotamine. Crotamine was purified from C.d. terrificus venom by Sephadex G-100 gel filtration followed by ion-exchange chromatography, and irradiated at 2 mg/ml in 0.15 M NaCl with 2.0 kGy gamma radiation emitted by a 60Co source. The native and irradiated toxins...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotamine; Gamma radiation; Chromatography; Toxicity; Circular dichroism.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200004
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New insights into the structural characteristics of irradiated crotamine J. Venom. Anim. Toxins incl. Trop. Dis.
Oliveira,Karina Corleto; Spencer,Patrick Jack; Ferreira Jr,Rui Seabra; Nascimento,Nanci.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gamma radiation; Structural modifications; Crotamine; Snake venom; Crotalus durissus terrificus.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100321
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Snake venoms and purified toxins as biotechnological tools to control Ralstonia solanacearum. Repositório Alice
ALVES, R. de C.; VIEIRA JUNIOR, J. R.; FREIRE, T. C.; FONSECA, A. S. da; SANGI, S. C.; BARBIERI, F. da S.; ROCHA, R. B.; BRITO, L. G.; PEREIRA, S. dos S.; LUIZ, M. B.; FREIRE, F. das C. O.; FERNANDES, C. F. C.; SOARES, A. M.; FERNANDES, C. de F..
Título em português: Venenos e toxinas ofídicas purificadas como ferramenta biotecnológica para o controle de Ralstonia solanacearum.
Tipo: Artigo de periódico Palavras-chave: Antimicrobial activity; Atividade antimicrobiana; Gyroxin; Crotamine; Giroxina; Crotamina; Murcha Bacteriana; Ralstonia Solanacearum; Toxina; Veneno; Bothrops; Crotalus; Bacterial wilt.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1130453
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