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Antimycobacterial and cytotoxicity activity of microcystins J. Venom. Anim. Toxins incl. Trop. Dis.
Ramos,Daniela Fernandes; Matthiensen,Alexandre; Colvara,Wilson; Votto,Ana Paula Souza de; Trindade,Gilma Santos; Silva,Pedro Eduardo Almeida da; Yunes,João Sarkis.
Background The present work aimed to evaluate the antimycobacterial activity and cytotoxicity of Microcystis aeruginosa toxins, the MC-LR variant and purified extract of [D-Leu1] microcystin-LR. Methods The antimicrobial activity of M. aeruginosa extract and microcystin was evaluated by resazurin microtiter assay against Mycobacterium tuberculosis, M. terrae, M. chelonae and M. kansasii. The cytotoxicity assay was performed by trypan blue exclusion against the HTC cell line. Results Antimicrobial activity was observed in the hexanic extract of M. aeruginosa (RST 9501 strain) against M. tuberculosis, including sensitive and resistant strains with minimal inhibitory concentrations (MIC) between 1.93 μM and 0.06 μM. The high activity of M. aeruginosa hexanic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacteria; Antimycobacterial agents; Cytotoxic activity; Microcystins.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100315
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Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum Anais da ABC (AABC)
RICARTE,LARA P.; BEZERRA,GABRIELI P.; ROMERO,NIRLA R.; SILVA,HORLANDO C. DA; LEMOS,TELMA L.G.; ARRIAGA,ANGELA M. C.; ALVES,PÉRICLES B.; SANTOS,MARCELO B. DOS; MILITÃO,GARDENIA C.G.; SILVA,THIAGO D.S.; BRAZ-FILHO,RAIMUNDO; SANTIAGO,GILVANDETE M.P..
Abstract The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aedes aegypti; Cytotoxic activity; Lamiaceae; Larvicidal activity.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100718
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Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.) Anais da ABC (AABC)
ANDRADE,PRISCILA M. DE; MELO,DAIANA C. DE; ALCOBA,ANA ELISA T.; FERREIRA JÚNIOR,WALNIR G.; PAGOTTI,MARIANA C.; MAGALHÃES,LIZANDRA G.; SANTOS,TAINÁ C.L. DOS; CROTTI,ANTÔNIO E.M.; ALVES,CASSIA C.F.; MIRANDA,MAYKER L.D..
Abstract Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, the leaf essential oil of Cryptocarya aschersoniana was obtained by hydrodistillation in a Clevenger-type apparatus, and the chemical composition was analyzed by GC-MS and GC-FID. The essential oil of these species was predominantly constituted by monoterpene hydrocarbons (48.8%). Limonene (42.3%), linalool (9.7%) and nerolidol (8.6%) were the main constituents in the oil of C. aschersoniana. The in vitro...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptocarya aschersoniana; Lauraceae; Essential oil; Leishmania amazonensis; Cytotoxic activity.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602671
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Cytotoxic activity of some marine brown algae against cancer cell lines Biol. Res.
KHANAVI,MAHNAZ; NABAVI,MARYAM; SADATI,NARGESS; SHAMS ARDEKANI,MOHAMMADREZA; SOHRABIPOUR,JELVE; NABAVI,SEYED MOHAMMAD B; GHAELI,PADIDEH; OSTAD,SEYED NASSER.
The aim of this study was to investigate the in vitro cytotoxic activity of total extract of MeOH (70%) and partition fractions of hexan, chloroform (CHCL3), ethylacetate (EtOAc) and MeOH-H2O of brown algae species (Sargassum swartzii, Cystoseira myrica, Colpomenia sinuosa) found in the Persian Gulf against in different cell lines including HT-29, Caco-2, T47D, MDA-MB468 and NIH 3T3 cell lines by MTT and AnnexinV-PI assay. The hexan fraction of S. swartzii and C. myrica showed selective cytotoxicity against proliferation of Caco-2 cells (IC50<100 &#956;g/ml) T47D cell line (IC50<100 &#956;g/ml), respectively. S. swartzii and C. myrica were also observed for increasing apoptosis in Caco-2 and T47D cells. Total extract and fractions of C....
Tipo: Journal article Palavras-chave: Colpomenia sinuosa; Cystoseira myrica; Cytotoxic activity; MTT assay; Persian Gulf; Sargassum swartzii.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100005
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In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae) BJMBR
Rosas,L.V.; Cordeiro,M.S.C.; Campos,F.R.; Nascimento,S.K.R.; Januário,A.H.; França,S.C.; Nomizo,A.; Toldo,M.P.A.; Albuquerque,S.; Pereira,P.S..
Ampelozizyphus amazonicus Ducke is a tree commonly found in the Amazon region and an extract of its stem bark is popularly used as an antimalarial and anti-inflammatory agent and as an antidote to snake venom. Ursolic acid; five lupane type triterpenes: betulin, betulinic acid, lupenone, 3ß-hydroxylup-20(29)-ene-27,28-dioic acid, and 2a,3ß-dihydroxylup-20(29)-ene-27,28-dioic acid, and three phytosteroids: stigmasterol, sitosterol and campesterol, have been isolated from stem extracts of A. amazonicus Ducke. Their structures were characterized by spectral data including COSY and HMQC. In an in vitro biological screening of the isolated compounds, 3ß-hydroxylup-20(29)-ene-27,28-dioic acid was cytotoxic against the SKBR-3 human adenocarcinoma cell line (1 to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ampelozizyphus amazonicus; Rhamnaceae; Pentacyclic triterpenes; Cytotoxic activity; Trypanocidal activity.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500009
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Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. Repositório Alice
CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, MARIA FRANCILENE SOUZA; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; Ó, C. DO; ZOCOLO, G. J..
bitstream/item/208397/1/ART19104.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Dereplication; UPLC-MS/MS; Hemometrics; Cytotoxic activity; Desreplicação; Quimiometria; Atividade citotóxica; Myracrodruon Urundeuva.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1118419
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Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva. Repositório Alice
CASTRO, C. B. DE; LUZ, L. DOS R.; GUEDES, J. A. C.; PORTO, D. D.; SILVA, MARIA FRANCILENE SOUZA; SILVA, G. S. DA; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; ZAMPIERI, D. DE S.; Ó, C. DO; ZOCOLO, G. J..
Myracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA)...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Dereplication; UPLC-MS/MS; Hemometrics; Cytotoxic activity; Desreplicação; Quimiometria; Atividade citotóxica; Aroeira do sertão; Bioma Caatinga; Myracrodruon Urundeuva; Aroeira; Caatinga; Espécie Nativa; Vegetação Nativa.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1119316
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Volatile constituents of Hyptis crenata Pohl (Labiatae) native in brazilian pantanal. Repositório Alice
SCRAMIM, S.; POTT, A.; MARQUES, M. O. M..
Fifteen compounds were identified in the essential oil of Hyptis crenata Pohl, which was analyzed by GC/MS. The main oil components were alpha-pinene (15,5%), beta-pinene (10,5%), camphor (17,3%), and beta-caryophyllene (10,7%). The volatile concetrate isolated from the distillation water contained 1,8-cineole (11,9%), camphor (37,3%) and beta- caryophyllene (14,7%).
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Essential oil; Compounds; Biological activity; Wild peppermint; Nematicidal activity; Cytotoxic activity; Acaricidal; Insecticidal; Properties; Oleos essenciais; Plantas medicinais; Atividade biologica; Sesquiterpenoides; Hortela-brava; Atividade nematicida; Atividade citotoxica; Propriedades; Acaricida; Inseticida; Medicinal plants; Sesquiterpenoids.
Ano: 2000 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/13188
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トキソブラズマ溶解抗原(TLA)によって誘導される細胞障害性における脾臓の付着性細胞の役割 OAK
MIYAHARA, Kazuro; TOSE, Shinichi; SAKURAI, Haruhisa; IGARASHI, Ikuo; SAITO, Atsushi; HIROSE, Tsuneo; SUZUKI, Naoyoshi; 宮原, 和郎; 五十嵐, 郁男.
In order to identify mechanisms responsible for the anti-tumor effects of Toxoplasma lysate antigen (TLA), we used an in vitro 51Cr release assay to study the functional properties of plastic-adherent cells during induction of splenic cytotoxic activity by TLA. Cytotoxic activity of non-adherent cells was measured in all experiments after a 6 days incubation. Induction of cytotoxic non-adherent cells by TLA required the presence of plastic-adherent spleen cells. In contrast, rhIL-2 alone was able to induce transformation of cytotoxic non-adherent cells from non-adherent spleen cells. Contact between adherent and non-adherent spleen cells was necessary for successful induction of cytotoxic non-adherent cells by TLA. Treatment of spleen cells with...
Palavras-chave: Adherent cell; Cytotoxic activity; Macrophage; Spleen cell; Toxoplasma lysate antigen.
Ano: 1992 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4065
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トキソプラズマ溶解抗原(TLA)で誘導されるマウス脾臓内の細胞障害性細胞の性質 OAK
MIYAHARA, Kazuro; MATSUMOTO, Toru; TOSE, Shinichi; SAKURAI, Haruhisa; IGARASHI, Ikuo; SAITO, Atsushi; HIROSE, Tsuneo; SUZUKI, Naoyoshi; 宮原, 和郎; 五十嵐, 郁男.
Spleen cells from Toxoplasma lysate antigen (TLA)-sensitized BALB/c mice showed the strong cytotoxic activity against both natural killer (NK)-sensitive cells (YAC-1 and RL♂-1) and NK-insensitive cells (P-815), when incubated with TLA or recombinant human IL-2 (rhIL-2). The increment of TLA concentration in culture medium increased the cytotoxic activity. Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity. Treatment of spleen cells from TLA-sensitized mice with anti-asialo GM1 and/or anti-Thy-1 plus complement...
Palavras-chave: Cytotoxic activity; Mouse; Phenotype; Spleen cell; Toxoplasma lysate antigen.
Ano: 1992 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4063
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