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Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis BJMBR
Fonseca,D.M.; Bonato,V.L.D.; Silva,C.L.; Sartori,A..
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular route, this vaccine elicited a predominant Th1 response that was consistent with its protective efficacy against tuberculosis. It has been suggested that the immune response to Hsp60/65 may be the link between exposure to microorganisms and increased cardiovascular risk. Additionally, the high cholesterol levels found in atherosclerosis could modulate host immunity. In this context, we evaluated if an atherogenic diet could modulate the immune response induced by the DNA-HSP65 vaccine. C57BL/6 mice (4-6 animals per group) were initially...
Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA-HSP65; Genetic vaccine; Atherosclerosis; Tuberculosis; Th1; Cholesterol.
Ano: 2007 URL:
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