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LC-MS characterization of valsartan degradation products and comparison with LC-PDA BJPS
Pires,Sumaia Araújo; Mota,Letícia Martins; Garcia,Jerusa Simone; Amaral,Phellipe Honorio; Meurer,Eduardo César; Eberlin,Marcos Nogueira; Trevisan,Marcello Garcia.
abstract Valsartan was submitted to forced degradation under acid hydrolysis condition as prescribed by the ICH. Degraded sample aliquots were separated via HPLC using a Hypersil ODS (C18) column (250 x 4.6 mm i.d., 5 µm). Either photodiode array (PDA) detection or mass spectrometry (MS) full scan monitoring of HPLC runs were used. HPLC-PDA failed to indicate Valsartan degradation under forced acid degradation, showing an insignificant peak area variation and that Valsartan apparently remained pure. HPLC-MS using electrospray ionization (ESI) and total ionic current (TIC) monitoring did not reveal any peak variation either, but inspection of the ESI mass spectra showed the appearance of m/z 306 and m/z 352 ions for the same retention time as that of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Valsartan; Stress testing; Degradation products; Stability-indicating; Acidic hydrolysis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400839
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Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations BJPS
Razzaq,Syed Naeem; Ashfaq,Muhammad; Mariam,Irfana; Khan,Islam Ullah; Razzaq,Syed Saleem.
The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress-induced degradation products. Both the drugs and their stress-induced degradation products were separated within 10 minutes using C8 column and mixture of methanol and 0.02 M phosphate buffer pH 3.0 (60:40 v/v, respectively) as mobile phase at 270 nm using diode array detector. Regression analysis showed linearity in the range of 15-105 µg/mL for sparfloxacin and 5-35 µg/mL for dexamethasone. All the analytes were adequately resolved with acceptable tailing. Peak purity of the two drugs was also greater than...
Tipo: Info:eu-repo/semantics/article Palavras-chave: RP-HPLC; Sparfloxacin; Dexamethasone; Degradation products; Stability studies.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200012
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Validation of a liquid chromatography ultraviolet method for determination of herbicide diuron and its metabolites in soil samples Anais da ABC (AABC)
FELICIO,ANA LUCIA S.M.; MONTEIRO,ALESSANDRA M.; ALMEIDA,MARIANA B.; MADEIRA,TIAGO B.; NIXDORF,SUZANA L.; YABE,MARIA JOSEFA S..
ABSTRACT Diuron is one of the most widely herbicide used worldwide, which can undergo degradation producing three primary metabolites: 3,4-dichlorophenylurea, 3-(3,4-dichlorophenyl)-1-methylurea, and 3,4-dichloroaniline. Since the persistence of diuron and its by-products in ecosystems involves risk of toxicity to environment and human health, a reliable quantitative method for simultaneous monitoring of these compounds is required. Hence, a simple method without preconcentration step was validated for quantitation of diuron and its main metabolites by high performance liquid chromatography with ultraviolet detection. Separation was achieved in less than 11 minutes using a C18 column, mobile phase composed of acetonitrile and water (45:55 v/v) at 0.86 mL...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pesticides; Degradation products; HPLC-UV; Soil; Environmental control.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401235
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