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| Registros recuperados: 56 | |
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| Laxminarayan, Ramanan. |
| In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies to replace this failing drug. Although there are strong theoretical arguments in favor of switching to more expensive artemisinin-based combination treatments (ACTs), the validity of these arguments in the face of financial constraints has not been previously analyzed. In this paper, we use a Bioeconomic model of malaria transmission and evolution of drug resistance to examine questions of optimal treatment strategy and coverage when drug resistance places an additional constraint on choices available to the... |
| Tipo: Working or Discussion Paper |
Palavras-chave: Malaria; Mathematical models; Drug resistance; Bioeconomics; Health Economics and Policy; I10; I19; C61. |
| Ano: 2003 |
URL: http://purl.umn.edu/10699 |
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| ALBUQUERQUE, L. B.; SILVA, A. C.; SANTOS, V. O.; FROTA, G. A.; VIEIRA, L. da S.; MONTEIRO, J. P.. |
| O objetivo do presente trabalho foi avaliar diferentes formas de montagem do TDL e verificar em quais delas foram obtidos os melhores ambientes para o desenvolvimento das larvas in vitro. Foram testadas diferentes formas de preparo da solução de ovos, sendo ela preparada separadamente com: água da torneira, água destilada, água destilada autoclavada, solução fisiológica (NaCl 0,9%) e solução salina fosfatada tamponada (PBS). |
| Tipo: Anais e Proceedings de eventos |
Palavras-chave: Solução fisiológica; PBS; Resistance to anthelmintics; Caprino; Parasitologia; Resistência; Anti-Helmíntico; Resistência Química; Nematóide; Helminto Gastrintestinal; Goat diseases; Goats; Parasitology; Gastrointestinal nematodes; Drug resistance; Brazil. |
| Ano: 2021 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1133313 |
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| Mohamudha,Parveen R.; Harish,B.N.; Parija,S.C.. |
| AmpC β-lactamases are cephalosporinases that hydrolyze cephamycins as well as other extended-spectrum cephalosporins and are poorly inhibited by clavulanic acid. Although reported with increasing frequency, the true rate of occurrence of AmpC β-lactamases in different organisms, including members of Enterobacteriaceae, remains unknown. The present study was designed to determine the occurrence of AmpC enzyme-harbouring Gram-negative clinical isolates in a tertiary care hospital in Pondicherry state, South India. A total of 235 Gram negative clinical isolates were tested for resistance to cefoxitin, third generation cephalosporin (3GC) antibiotics, ampicillin, amikacin, co-trimoxazole, gentamicin, meropenem and tetracycline by disc diffusion method.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gram negative organisms; Drug resistance; Three-dimensional technique; AmpC β-lactamases. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000300009 |
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| MENEZES, L. M. F; ÂNGELO, F. F.; ALCINDO, J. F.; SÁ, D. M. A.; LIMA, A. R.; ARAUJO, R. F.; MESQUITA, F. L. T.; SOUZA, V. de. |
| Caprine mastitis is one of the most common diseases in dairy herds, causing damage mainly due to the decrease in milk production after the invasion of the infectious agent in the secretory epithelium of the mammary gland. Species Staphylococcus aureus is the most pathogenic agent in the mammary gland, having important implications for public health, since it produces enterotoxins that survive the heat treatments applied to milk. The use of proper antibiotics is an important tool for the treatment of the disease. However, they should be used judiciously, since the main cause of failure in therapy is bacterial resistance to the drug. This study uses an antibiogram to evaluate the resistance of microorganisms isolated from goat milk samples with subclinical... |
| Tipo: Anais e Proceedings de eventos |
Palavras-chave: Resistance to antibiotics; Resistance to chemicals; Antimicrobial resistance; Tratamento químico; Resistência a medicamento; Mamite; Caprino; Cabra Leiteira; Doença Animal; Antibiótico; Resistência Química; Goat diseases; Goat milk; Chemical treatment; Public health; Drug resistance. |
| Ano: 2019 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1114014 |
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| Mendes,Caio; Oplustil,Carmen; Sakagami,Elsa; Turner,Philip; Kiffer,Carlos. |
| OBJECTIVE: Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2002. MATERIAL AND METHODS: Gram-negative bacteria (n = 503) causing nosocomial infections were collected at seven Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by E-test methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). RESULTS: Pseudomonas aeruginosa (33%) was the most frequently isolated, followed by A. baumannii (17.1%), K. pneumoniae... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100008 |
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| Kiffer,Carlos; Hsiung,Andre; Oplustil,Carmen; Sampaio,Jorge; Sakagami,Elsa; Turner,Philip; Mendes,Caio. |
| Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2003. Gram-negative bacteria (n = 1,550) causing nosocomial infections were collected at 20 Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by Etest methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). Pseudomonas aeruginosa (30.3%) was the most frequent isolate, followed by E. coli (18.6%), Klebsiella pneumoniae (16.9%), Acitenobacter baumannii (8.8%), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300004 |
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| Weber,F. T.; Dias,C.; Costa,M. da. |
| The antimicrobial susceptibility of 64 strains of S. pneumoniae obtained from three hospitals in Porto Alegre, Brazil, isolated between 2004 and 2005, was determined, using the agar-dilution method. The prevalence of resistant (intermediate and full resistance) strains to trimethoprim/sulphamethoxazole, penicillin, tetracycline, erythromycin, chloramphenicol, and ceftriaxone were 68%, 28%, 18%, 15%, 3%, and 1%, respectively. All strains were susceptible to vancomycin. Among 18 penicillin-resistant strains, 7 were resistant to at least two other antimicrobial drugs. All erythromycin-resistant strains, except one, contained the erm(B) and/or mef(A/E) genes, with a predominance of the former. The resistance rate to penicillin and erythromycin in Porto Alegre... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Streptococcus pneumoniae; Drug resistance; Erm(B); Mef(A/E). |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000100001 |
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| Villegas,Maria Virginia; Briceno,David Felipe; Ruiz,Sory Jamil; Furtado,Guilherme H; Nicolau,David P. |
| OBJECTIVES: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC distribution data to determine which of the tested carbapenem regimens provided the greatest opportunity for obtaining maximal pharmacodynamic (PD) activity. METHODS: The isolates studied were obtained from the COMPACT-COLOMBIA surveillance program conducted between February and November 2009. Antimicrobial susceptibility testing was conducted by broth microdilution method according to the CLSI guidelines. Doripenem, imipenem-cilastatin, and meropenem, were the modeled antibiotics. A 5,000 patient Monte... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug resistance; Bacterial; Gram-negative bacteria; Monte Carlo Method; Colombia; Pharmacology. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500001 |
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| De Oliveira-júnior, Raimundo Gonçalves; Nicolau, Elodie; Bonnet, Antoine; Prunier, Grégoire; Beaugeard, Laureen; Joguet, Nicolas; Thiéry, Valérie; Picot, Laurent. |
| Melanoma is an aggressive tumor with invasive and metastatic potential, frequently exhibiting multidrug resistance mechanisms. In our continuous search for antimelanoma molecules, we have identified some effective marine compounds capable of not only inducing cell death, but also of sensitizing chemoresistant tumor cells to clinically used anticancer drugs. In this report, the cryptophyte Rhodomonas salina (Wislouch) D.R.A.Hill & R.Wetherbee, Pyrenomonadaceae, was chemically investigated in order to identify pigments efficiently inhibiting melanoma cells proliferation. All pharmacological tests were performed on A2058 cells expressing the oncogenic BRAF V600E mutation and resistant to dacarbazine treatment. Flash chromatography of R. salina ethanol... |
| Tipo: Text |
Palavras-chave: Alloxanthin; Chemosensitivity; Crocoxanthin; Cutaneous melanoma; Drug resistance; Microalgae. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00630/74194/73918.pdf |
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| Araujo,Orlei Ribeiro de; Silva,Dafne Cardoso Bourguignon da; Diegues,Ana Regina; Arkader,Ronaldo; Cabral,Eloíza Aparecida Ferreira; Afonso,Marta Rodriguez; Louzada,Maria Eduarda; Albertoni,Andréa de Cássia Stéfano. |
| Antibiotic restriction can be useful in maintaining bacterial susceptibility. The objective of this study was verify if restriction of cefepime, the most frequently used cephalosporin in our neonatal intensive care unit (NICU), would ameliorate broad-spectrum susceptibility of Gram-negative isolates. Nine hundred and ninety-five premature and term newborns were divided into 3 cohorts, according to the prevalence of cefepime use in the unit: Group 1 (n=396) comprised patients admitted from January 2002 to December 2003, period in which cefepime was the most used broad-spectrum antibiotic. Patients in Group 2 (n=349) were admitted when piperacillin/tazobactam replaced cefepime (January to December 2004) and in Group 3 (n=250) when cefepime was reintroduced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Drug resistance; Infection control; Cefepime; Bacterial. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200022 |
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| Shinde,Ravikumar Bapurao; Raut,Jayant Shankar; Chauhan,Nitin Mahendra; Karuppayil,Sankunny Mohan. |
| Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antifungal; Biofilm; Candida albicans; Combination; Chloroquine; Drug resistance. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400002 |
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| Sanchotene,Karine O.; von Groll,Andrea; Ramos,Daniela; Scholante,Ana B.; Honscha,Gunther; Valença,Mariana; Scaini,Carlos J.; Silva,Pedro E.A. da. |
| Tuberculosis remains as a serious infection disease of worldwide distribution, with high morbidity and mortality, mainly in low socio-economic condition countries. The state of emergency of tuberculosis caused by the resistant and multidrug-resistant (MDR) strains, became the main threat to the tuberculosis treatment and control programs. A fast detection method for the resistant strains will allow the implementation of an adequate treatment and contribute for controlling the dissemination of these resistant strains. This study evaluated the performance of the nitrate reductase assay in solid (NRA-LJ) and liquid (NRA-7H9) media, to determine the susceptibility to first line anti-tuberculosis drugs: isoniazid (INH), rifampicin (RMP), ethambutol (EMB) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tuberculosis; Mycobacterium tuberculosis; Nitrate reductase assay; Susceptibility tests; Drug resistance. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000100004 |
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| Registros recuperados: 56 | |
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