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Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review 60
Kushwaha,Swatantra Kumar Singh; Ghoshal,Saurav; Rai,Awani Kumar; Singh,Satyawan.
Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbon nanotubes/properties; Carbon nanotubes/use; Carbon nanotubes/drugs delivery; Single-Walled Carbon Nanotube; Multiwalled Carbon Nanotube; Anticancer drugs/delivery; Cancer/therapy; Drugs/delivery.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400002
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Mucoadhesive drug delivery systems 60
Carvalho,Flávia Chiva; Bruschi,Marcos Luciano; Evangelista,Raul Cesar; Gremião,Maria Palmira Daflon.
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100002
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