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Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells Inra
Joffre, C.; Souchier, M.; Leclere, L.; Buteau, B.; Grégoire, S.; Lizard, G.; Montange, T.; Acar, N.; Bron, A.; Creuzot Garcher, C.; Diebold, Y.; Bretillon, L..
Aim: The composition of the meibum of blepharitis patients is characterised by increased levels of branched-chain fatty acids (BCFAs) that return to normal values in patients treated with cyclins and lid hygiene. The aim of this study was to determine if BCFAs had toxic effects on conjunctival cells related to the disease.Methods: Chang and IOBA-NHC conjunctival human cells were treated with BCFAs (isoC16 and isoC20) or palmitic acid as a control for 4 h or 24 h at 50 μM or 100 μM. Morphological and functional changes were investigated by measuring mitochondrial dehydrogenase activity, cell permeability, mitochondrial depolarisation, chromatin condensation, IL-1β and reactive oxygen species production.Results: None of the fatty acids modified the...
Tipo: Journal Article Palavras-chave: DRY EYE; BENZALKONIUM CHLORIDE; EPITHELIAL-CELLS; MUSCLE CELLS; LIPID LAYER; APOPTOSIS; MEMBRANE; MARKER.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20105cdf51fe&uri=/notices/prodinra1/2010/07/
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Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1α requires interaction with cell surface heparan sulfate proteoglycans Inra
Valenzuela-Fernandez, A.; Palanche, T.; Amara, A.; Magerus, A.; Altmeyer, R.; Delaunay, T.; Virelizier, J.L.; Baleux, F.; Galzi, J.L.; Arenzana-Seisdedos, F..
The chemokine stromal cell-derived factor 1 (SDF-1) is the natural ligand for CXC chemokine receptor 4 (CXCR4). SDF-1 inhibits infection of CD4+ cells by X4 (CXCR4-dependent) human immunodeficiency virus (HIV) strains. We previously showed that SDF-1α interacts specifically with heparin or heparan sulfates (HSs). Herein, we delimited the boundaries of the HS-binding domain located in the first β-strand of SDF-1α as the critical residues. We also provide evidence that binding to cell surface heparan sulfate proteoglycans (HSPGs) determines the capacity of SDF-1α to prevent the fusogenic activity of HIV-1 X4 isolates in leukocytes. Indeed, SDF-1α mutants lacking the capacity to interact with HSPGs showed a substantially reduced capacity to prevent...
Tipo: Journal Article Palavras-chave: HIV; TEST PAR FLUORESCENCE; CYTOMÉTRIE DE FLUX; SDF-1; PROTEOGLYCAN HEPARAN SULFATE MEMBRANAIRE; CONSTANTE CINÉTIQUE; ANTICORPS MONOCLONAL; FLUORESCENCE RECEPTOR CXCR4; DENDRITIC CELLS; LYMPHOCYTE CHEMOATTRACTANT; GASTROINTESTINAL-TRACT; ENVELOPE GLYCOPROTEIN; EPITHELIAL-CELLS; RHESUS MACAQUES; FACTOR-I; T-CELLS; SDF-1.
Ano: 2001 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0200011223090281&uri=/notices/prodinra1/2010/10/
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