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| ANDREOTTI, R.; AGUIRRE, A. A. R.; CSORDAS, B. G.; BLECHA, I. M. Z.; CUNHA, R. C.; GARCIA, M. V.; HIGA, L.; OSHIRO, L. M.; RODRIGUES, V. S.; DUARTE, P. O.; BARROS, J. C.. |
| bitstream/item/168992/1/Bm86-protein-epitope-polymorphisms.pdf |
| Tipo: Resumo em anais de congresso (ALICE) |
Palavras-chave: Bm86; Immunobioinformatics; Ticks; Epitopes; Genetic variation. |
| Ano: 2017 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1082528 |
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| MACHADO-DE-ÁVILA, R. A.; VELLOSO, M.; OLIVEIRA, D.; STRANSKY, S.; FLOR-SÁ, A.; SCHNEIDER, F. S.; NESHICH, G.; CHÁVEZ-OLÓRTEGUI, C.. |
| Mutalysin-II, from Lachesis muta muta snake venom, is an endopeptidase with hemorrhagic activity. To identify a conformational epitope we used Blue Star Sting, the latest version of the web based Sting Millenium Suite, as alternative computational analysis tool to select and design peptides. Pre-selected cut-off values of the accessibility and hydrophilicity parameters were used to select amino acid residues as potential conformational epitopes. A peptide (P117-Y116-C115-Q194-C195-L197-N198-K199-P200-Y5-L48) was manually drawn on Swiss-PDB-Viewer package and synthesized by Fmoc-synthesis. Immunization of rabbits with this peptide induced antibodies that recognized Mutalysin-II and protected against the hemorrhagic factors present in Lachesis venom. The... |
| Tipo: Artigo em periódico indexado (ALICE) |
Palavras-chave: Peptídeos; Sting millennium; Conformational epitope prediction; Veneno; Lachesis muta; Antivenoms; Synthetic peptides; Epitopes. |
| Ano: 2015 |
URL: http://www.alice.cnptia.embrapa.br/handle/doc/1032210 |
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