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Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function BJMBR
Brum,P.C.; Bacurau,A.V.N.; Medeiros,A.; Ferreira,J.C.B.; Vanzelli,A.S.; Negrão,C.E..
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Exercise training; Sympathetic hyperactivity; Ventricular function; Cardiac remodeling; Skeletal myopathy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900002
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Cardiovascular control in experimental diabetes BJMBR
De Angelis,K.; Schaan,B.D.; Maeda,C.Y.; Dall'Ago,P.; Wichi,R.B.; Irigoyen,M.C..
Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental diabetes; Arterial pressure; Autonomic control; Baroreflex; Chemoreflex; Cardiopulmonary reflex; Exercise training.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900010
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Comparison of endoplasmic reticulum stress and mitochondrial biogenesis responses after 12 weeks of treadmill running and ladder climbing exercises in the cardiac muscle of middle-aged obese rats BJMBR
Kim,Kijin; Ahn,Nayoung; Jung,Suryun.
The purpose of the present study was to compare the influence of aerobic exercise (AE) lasting 12 weeks to that of resistance exercise (RE) of the same duration on endoplasmic reticulum (ER) stress and mitochondrial biogenesis in the cardiac muscle of middle-aged obese rats. Obesity was induced in thirty 50-week-old male Sprague Dawley rats over 6 weeks by administration of a high-fat diet. The rats were then subjected to treadmill-running (AE) and ladder-climbing (RE) exercises 3 times per week for 12 weeks. Rats in the AE group showed significantly lower increases in body weight and intraperitoneal fat than those in the sedentary control (SC) group (P<0.05). The 12-week exercise regimes resulted in a significant increase in expression of mitochondrial...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Mitochondrial biogenesis; Endoplasmic reticulum stress; Obesity; Cardiac muscle; Aging.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000604
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Comparison of morning and afternoon exercise training for asthmatic children BJMBR
Silva,C.S.; Torres,L.A.G.M.M.; Rahal,A.; Terra Filho,J.; Vianna,E.O..
Fitness improvement was used to compare morning with afternoon exercise periods for asthmatic children. Children with persistent moderate asthma (according to GINA criteria), 8 to 11 years old, were divided into 3 groups: morning training group (N = 23), afternoon training group (N = 23), and non-training group (N = 23). The program was based on twice a week 90-min sessions for 4 months. We measured the 9-min running distance, resting heart rate and abdominal muscle strength (sit-up number) before and after the training. All children took budesonide, 400 µg/day, and an on demand inhaled ß-agonist. The distance covered in 9 min increased (mean ± SEM) from 1344 ± 30 m by 248 ± 30 m for the morning group, from 1327 ± 30 m by 162 ± 20 m for the afternoon...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Children; Chronotherapy; Exercise training; Circadian rhythm; Exercise-induced bronchospasm.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100008
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Domestication compromises athleticism and respiratory plasticity in response to aerobic exercise training in Atlantic salmon (Salmo salar) ArchiMer
Zhang, Yangfan; Timmerhaus, Gerrit; Anttila, Katja; Mauduit, Florian; Jorgensen, Sven Martin; Kristensen, Torstein; Claireaux, Guy; Takle, Harald; Farrell, Anthony P..
Commercially selective breeding of Atlantic salmon (Salmo salar) primarily for rapid growth may compromise cardiorespiratory robustness and its related phenotypes. Therefore, a suite of respiratory indices was used to evaluate aerobic capacity and hypoxia tolerance to test the hypothesis that exercise training can improve the athletic robustness in both domesticated and wild strains of Atlantic salmon, but with the domesticated strain having a less cardiorespiratory plasticity and a lower athletic robustness than the wild strain. We also tested a second hypothesis that a constant acceleration screening protocol should segregate fish according to athletic robustness based on their swimming ability. These hypotheses were tested with parr from Bolaks...
Tipo: Text Palavras-chave: Athletic robustness; Atlantic salmon; Domestication; Exercise training; Hypoxia tolerance; Respiratory performance.
Ano: 2016 URL: https://archimer.ifremer.fr/doc/00334/44518/44214.pdf
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Duration-controlled swimming exercise training induces cardiac hypertrophy in mice BJMBR
Evangelista,F.S.; Brum,P.C.; Krieger,J.E..
Exercise training associated with robust conditioning can be useful for the study of molecular mechanisms underlying exercise-induced cardiac hypertrophy. A swimming apparatus is described to control training regimens in terms of duration, load, and frequency of exercise. Mice were submitted to 60- vs 90-min session/day, once vs twice a day, with 2 or 4% of the weight of the mouse or no workload attached to the tail, for 4 vs 6 weeks of exercise training. Blood pressure was unchanged in all groups while resting heart rate decreased in the trained groups (8-18%). Skeletal muscle citrate synthase activity, measured spectrophotometrically, increased (45-58%) only as a result of duration and frequency-controlled exercise training, indicating that endurance...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Swimming; Cardiac hypertrophy; Mice; Myocardium.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200018
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Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants BJMBR
Fernandes,T.; Soci,U.P.R.; Oliveira,E.M..
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Cardiac hypertrophy; Renin-angiotensin system; AT1 receptor; Akt; MicroRNAs.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900003
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Effect of exercise training and carvedilol treatment on cardiac function and structure in mice with sympathetic hyperactivity-induced heart failure BJMBR
Medeiro,A.; Vanzelli,A.S.; Rosa,K.T.; Irigoyen,M.C.; Brum,P.C..
The present investigation was undertaken to study the effect of β-blockers and exercise training on cardiac structure and function, respectively, as well as overall functional capacity in a genetic model of sympathetic hyperactivity-induced heart failure in mice (α2A/α2CArKO). α2A/α2CArKO and their wild-type controls were studied for 2 months, from 3 to 5 months of age. Mice were randomly assigned to control (N = 45), carvedilol-treated (N = 29) or exercise-trained (N = 33) groups. Eight weeks of carvedilol treatment (38 mg/kg per day by gavage) or exercise training (swimming sessions of 60 min, 5 days/week) were performed. Exercise capacity was estimated using a graded treadmill protocol and HR was measured by tail cuff. Fractional shortening was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Exercise training; Carvedilol treatment; Ventricular function; Cardiac remodeling; Α2A/α2CArKO mice.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900012
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Effect of exercise training on ventilatory efficiency in patients with heart disease: a review BJMBR
Prado,D.M.L.; Rocco,E.A.; Silva,A.G.; Rocco,D.F.; Pacheco,M.T.; Furlan,V..
The analysis of ventilatory efficiency in cardiopulmonary exercise testing has proven useful for assessing the presence and severity of cardiorespiratory diseases. During exercise, efficient pulmonary gas exchange is characterized by uniform matching of lung ventilation with perfusion. By contrast, mismatching is marked by inefficient pulmonary gas exchange, requiring increased ventilation for a given CO2 production. The etiology of increased and inefficient ventilatory response to exercise in heart disease is multifactorial, involving both peripheral and central mechanisms. Exercise training has been recommended as non-pharmacological treatment for patients with different chronic cardiopulmonary diseases. In this respect, previous studies have reported...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart disease; Ventilatory efficiency; Exercise test; Exercise training.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700301
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Effect of gender on training-induced vascular remodeling in SHR BJMBR
Amaral,S.L.; Michelini,L.C..
There is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Hypertension; Microcirculation; Arterioles; Capillaries; Venules.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900001
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Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation BJMBR
Durigan,J.L.Q.; Peviani,S.M.; Russo,T.L.; Silva,A.C.D.; Vieira,R.P.; Martins,M.A.; Carvalho,C.R.F.; Salvini,T.F..
We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trained (C); 2) ovalbumin sensitized (OA, 20 µg per mouse); 3) non-sensitized and trained at 50% maximum speed _ low intensity (PT50%); 4) non-sensitized and trained at 75% maximum speed _ moderate intensity (PT75%); 5) OA-sensitized and trained at 50% (OA+PT50%), 6) OA-sensitized and trained at 75% (OA+PT75%). There was no difference in muscle fiber cross-sectional area among groups and no difference in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Muscle atrophy; Asthma; Gene expression; Mice.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400005
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Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats BJMBR
De Angelis,K.L.D.; Oliveira,A.R.; Dall'Ago,P.; Peixoto,L.R.A.; Gadonski,G.; Lacchini,S.; Fernandes,T.G.; Irigoyen,M.C..
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental diabetes; Exercise training; Arterial pressure; Autonomic control; Myocardial contractility.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600004
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Effects of losartan combined with exercise training in spontaneously hypertensive rats BJMBR
Azevedo,L.F.; Brum,P.C.; Mattos,K.C.; Junqueira,C.M.; Rondon,M.U.P.B.; Barretto,A.C.P.; Negrao,C.E..
We investigate whether combined treatment with losartan, an angiotensin II receptor blocker, and exercise training (ET) in spontaneously hypertensive rats (SHR) would have an additive effect in reducing hypertension and improving baroreflex sensitivity when compared with losartan alone. Male SHR (8 weeks old) were assigned to 3 groups: sedentary placebo (SP, N = 16), sedentary under losartan treatment (SL, N = 11; 10 mg kg-1 day-1, by gavage), and ET under losartan treatment (TL, N = 10). ET was performed on a treadmill 5 days/week for 60 min at 50% of peak VO2, for 18 weeks. Blood pressure (BP) was measured with a catheter inserted into the carotid artery, and cardiac output with a microprobe placed around the ascending aorta. The baroreflex control of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spontaneously hypertensive rats; Exercise training; Losartan; Baroreflex sensitivity.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100018
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Exercise training prevents increased intraocular pressure and sympathetic vascular modulation in an experimental model of metabolic syndrome BJMBR
Castro,E.F.S.; Mostarda,C.T.; Rodrigues,B.; Moraes-Silva,I.C.; Feriani,D.J.; De Angelis,K.; Irigoyen,M.C..
The present study aimed to study the effects of exercise training (ET) performed by rats on a 10-week high-fructose diet on metabolic, hemodynamic, and autonomic changes, as well as intraocular pressure (IOP). Male Wistar rats receiving fructose overload in drinking water (100 g/L) were concomitantly trained on a treadmill for 10 weeks (FT group) or kept sedentary (F group), and a control group (C) was kept in normal laboratory conditions. The metabolic evaluation comprised the Lee index, glycemia, and insulin tolerance test (KITT). Arterial pressure (AP) was measured directly, and systolic AP variability was performed to determine peripheral autonomic modulation. ET attenuated impaired metabolic parameters, AP, IOP, and ocular perfusion pressure (OPP)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fructose; Exercise training; Intraocular pressure; Autonomic modulation.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400332
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Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women BJMBR
Esposti,R.D.; Sponton,C.H.G.; Malagrino,P.A.; Carvalho,F.C.; Peres,E.; Puga,G.M.; Novais,I.P.; Albuquerque,D.M.; Rodovalho,C.; Bacci,M.; Zanesco,A..
The health-promoting effects of exercise training (ET) are related to nitric oxide (NO) production and/or its bioavailability. The objective of this study was to determine whether single nucleotide polymorphism of the endothelial NO synthase (eNOS) gene at positions -786T>C, G894T (Glu298Asp) and at the variable number of tandem repeat (VNTR) Intron 4b/a would interfere with the cardiometabolic responses of postmenopausal women submitted to physical training. Forty-nine postmenopausal women were trained in sessions of 30-40 min, 3 days a week for 8 weeks. Genotypes, oxidative stress status and cardiometabolic parameters were then evaluated in a double-blind design. Both systolic and diastolic blood pressure values were significantly reduced after ET,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; ENOS polymorphism; Oxidative stress; Nitric oxide; Women.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900005
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L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs BJMBR
Borghi-Silva,A.; Baldissera,V.; Sampaio,L.M.M.; Pires-DiLorenzo,V.A.; Jamami,M.; Demonte,A.; Marchini,J.S.; Costa,D..
The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic obstructive pulmonary disease; L-carnitine; Exercise training; Respiratory muscle training; Blood lactate.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400006
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Loss of resting bradycardia with detraining is associated with intrinsic heart rate changes BJMBR
Evangelista,F.S.; Martuchi,S.E.D.; Negrão,C.E.; Brum,P.C..
The mechanisms underlying the loss of resting bradycardia with detraining were studied in rats. The relative contribution of autonomic and non-autonomic mechanisms was studied in 26 male Wistar rats (180-220 g) randomly assigned to four groups: sedentary (S, N = 6), trained (T, N = 8), detrained for 1 week (D1, N = 6), and detrained for 2 weeks (D2, N = 6). T, D1 and D2 were treadmill trained 5 days/week for 60 min with a gradual increase towards 50% peak VO2. After the last training session, D1 and D2 were detrained for 1 and 2 weeks, respectively. The effect of the autonomic nervous system in causing training-induced resting bradycardia and in restoring heart rate (HR) to pre-exercise training level (PET) with detraining was examined indirectly after...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Exercise training; Cardiac autonomic balance; Heart rate; Peak oxygen uptake; Detraining.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700018
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Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats BJMBR
Mi,Chunjuan; Qin,Xinghua; Hou,Zuoxu; Gao,Feng.
The progression of myocardial injury secondary to hypertension is a complex process related to a series of physiological and molecular factors including oxidative stress. This study aimed to investigate whether moderate-intensity exercise (MIE) could improve cardiac function and oxidative stress in spontaneously hypertensive rats (SHRs). Eight-week-old male SHRs and age-matched male Wistar-Kyoto rats were randomly assigned to exercise training (treadmill running at a speed of 20 m/min for 1 h continuously) or kept sedentary for 16 weeks. Cardiac function was monitored by polygraph; cardiac mitochondrial structure was observed by scanning electron microscope; tissue free radical production was measured using dihydroethidium staining. Expression levels of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; SHR; Oxidative stress; SIRT3/SOD2; Mitochondria function.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600603
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Pleiotropic effects of simvastatin in physically trained ovariectomized rats BJMBR
Bernardes,N.; Brito,J.O.; Fernandes,T.G.; Llesuy,S.F.; Irigoyen,M.C.; Belló-Klein,A.; De Angelis,K..
This study tested the hypothesis that simvastatin treatment can improve cardiovascular and autonomic functions and membrane lipoperoxidation, with an increased effect when applied to physically trained ovariectomized rats. Ovariectomized rats were divided into sedentary, sedentary+simvastatin and trained+simvastatin groups (n = 8 each). Exercise training was performed on a treadmill for 8 weeks and simvastatin (5 mg/kg) was administered in the last 2 weeks. Blood pressure (BP) was recorded in conscious animals. Baroreflex sensitivity was evaluated by the tachycardic and bradycardic responses to BP changes. Cardiac vagal and sympathetic effects were determined using methylatropine and propranolol. Oxidative stress was evaluated based on heart and liver...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Menopause; Exercise training; Simvastatin; Autonomic function; Oxidative stress.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500447
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Psychiatric disorders and cardiac anxiety in exercising and sedentary coronary artery disease patients: a case-control study BJMBR
Sardinha,A.; Araújo,C.G.S.; Nardi,A.E..
Regular physical exercise has been shown to favorably influence mood and anxiety; however, there are few studies regarding psychiatric aspects of physically active patients with coronary artery disease (CAD). The objective of the present study was to compare the prevalence of psychiatric disorders and cardiac anxiety in sedentary and exercising CAD patients. A total sample of 119 CAD patients (74 men) were enrolled in a case-control study. The subjects were interviewed to identify psychiatric disorders and responded to the Cardiac Anxiety Questionnaire. In the exercise group (N = 60), there was a lower prevalence (45 vs 81%; P < 0.001) of at least one psychiatric diagnosis, as well as multiple comorbidities, when compared to the sedentary group (N =...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Mental health; Depression; Cardiovascular disease; Cardiac rehabilitation.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200031
Registros recuperados: 23
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