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In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia) ArchiMer
Hughes, Kristelle; Ho, Raimana; Chazaud, Claire; Hermitte, Stéphanie; Greff, Stéphane; Butaud, Jean-françois; Filaire, Edith; Ranouille, Edwige; Berthon, Jean-yves; Raharivelomanana, Phila.
Fagraea berteroana is a tree used in traditional medicine in various islands of the South Pacific. Here, we studied its hair growth-inducing properties as suggested by one of its Marquesan ethno-uses in haircare. The ethyl acetate extract of the fruits of F. berteroana (FEAE) and four resulting fractions (FEAE-F0, FEAE-F1, FEAE-F2, and FEAE-F3) were tested on hair follicle dermal papilla cells to determine their cell proliferative activity. Furthermore, RT-qPCR analysis enabled gene modulation analysis, while immunostaining of the β-catenin protein was used to follow protein regulation. We found that the plant extracts induced a controlled, dose-dependent cell proliferation. FEAE-F0 simultaneously down-regulated Bone Morphogenetic Protein 2 (BMP2) mRNA...
Tipo: Text Palavras-chave: Fagraea berteroana; Hair growth; Ethnocosmetology; Marquesas islands; Gentianaceae.
Ano: 2021 URL:
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