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| Abdon,A.P.V.; Leal-Cardoso,J.H.; Coelho-de-Souza,A.N.; Morais,S.M.; Santos,C.F.. |
| Croton nepetaefolius Baill., is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hot-plate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N =... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Croton nepetaefolius; Essential oil; Analgesic; Antinociception; Formalin test; Hot-plate test. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000015 |
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| Lugo-Lugo,Daniela Elizabeth; Pozos-Guillén,Amaury de Jesús; Zapata-Morales,Juan Ramón; Rodríguez-Chong,Antonio; Rangel-López,Azahel de Jesús; Saavedra-Leos,María Zenaida; Vértiz-Hernández,Angel Antonio. |
| Eugenol has been employed for decades as a condiment, an antimycotic, an antibacterial, an antiviral, and an antioxidant, and it is one of the natural analgesics most frequently utilized for pain and inflammation. Our objective was to determine the analgesic/anti-inflammatory effect of eugenol compared with diclofenac, naproxen, and tramadol using the formalin test. The formalin method was used in 6- to 10-week-old Wistar rats (weighing 250 g each) divided into six groups: saline (0.9%); formalin (5%); diclofenac (250 µg/kg); naproxen (400 µg/kg); tramadol (500 µg/kg), and eugenol (1,400 µg/kg), in the intraplantar part of the hind-end trunk of the rats, with n = 5 per group. Eugenol diminished 44.4% of nociceptive behavior in phase 1 and 48% in phase 2 (p... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eugenol/analgesic/anti-inflammatory effect; Diclofenac effect; Antinociception; Formalin test; Pain. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100536 |
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| Silva Neto,José Antônio Paixão da; Menezes,Larissa Dias; Gomes,Gúbio Oliveira; Cunha,Elise Marques Freire; Azevedo,Mariângela Soares de; Ferreira,Vania Moraes; Silva,Mônica Valero da. |
| Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oil and Water Cream; Medicinal plant; Paw edema test; Formalin test. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200012 |
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| Matos,Anne Caroline C; Teixeira-Silva,Flavia; Goes,Tiago C; Quintans Júnior,Lucindo J; Albuquerque Júnior,Ricardo Luiz C; Bonjardim,Leonardo R. |
| The aims of the present study were to assess the influence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Forty-four rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profiles. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait anxiety when presenting values below the 1st quartile, or above the 3rd quartile, respectively. A week later, formalin-1.5% was injected into the upper lip of each animal. The behavioural nociceptive response, characterized by increased orofacial rubbing (OR), was quantified for 30 minutes, as follows: Total time OR (0-30 minutes: total pain), 1st phase OR (0-6... |
| Tipo: Journal article |
Palavras-chave: Trait anxiety; Formalin test; Orofacial nociception; State anxiety. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400007 |
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