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ANT2 isoform required for cancer cell glycolysis Inra
Chevrollier, A.; Loiseau, D.; Chabi, B.; Renier, G.; Douay, O.; Malthièry, Y.; Stepien, G..
The three adenine nucleotide translocator (ANT1 to ANT3) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. In contrast to differentiated tissue cells, transformed cells, and their rho(0) derivatives, i.e. cells deprived of mitochondrial DNA, sustain a high rate of glycolysis. We compared the expression pattern of ANT isoforms in several transformed human cell lines at different stages of the cell cycle. The level of ANT2 expression and glycolytic ATP production in these cell lines were in keeping with their metabolic background and their state of differentiation. The sensitivity of the mitochondrial inner membrane potential (Delta psi) to...
Tipo: Journal Article Palavras-chave: CARCINOGENESE; ADENINE NUCLEOTIDE TRANSLOCATOR CARCINOGENESIS; MITOCHONDRIA; GLYCOLYSIS; ADENINE NUCLEOTIDE TRANSLOCATOR.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009b292a44&uri=/notices/prodinra1/2010/11/
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The glycolytic genes pfk and pyk from Lactobacillus casei are induced by sugars transported by the phosphoenolpyruvate:sugar phosphotransferase system and repressed by CcpA Inra
Viana, R.; Pérez-Martinez, G.; Deutscher, J.; Monedero, V..
In Lactobacillus casei BL23, phosphofructokinase activity was higher in cells utilizing sugars transported by the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The phosphofructokinase gene (pfk) was cloned from L. casei and shown to be clustered with the gene encoding pyruvate kinase (pyk). pfk and pyk genes are cotranscribed and induced upon growth on sugars transported by the PTS. Contrarily to the model proposed for Lactococcus lactis, where the global catabolite regulator protein (CcpA) is involved in PTS-induced transcription of pfk and pyk, a ccpA mutation resulted in a slight increase in pfk–pyk expression in L. casei. This weak regulation was evidenced by CcpA binding to a region of the pfk–pyk promoter which contained two cre...
Tipo: Journal Article Palavras-chave: PTS; CATABOLITE REPRESSION; GLYCOLYSIS; PHOSPHOTRANSFERASE SYSTEM; CCPA.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2006bbba8d60&uri=/notices/prodinra1/2010/10/
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