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Gadolinium increases the vascular reactivity of rat aortic rings 56
Angeli,J.K.; Ramos,D.B.; Casali,E.A.; Souza,D.O.G.; Sarkis,J.J.F.; Stefanon,I.; Vassallo,D.V.; Fürstenau,C.R..
Gadolinium (Gd) blocks intra- and extracellular ATP hydrolysis. We determined whether Gd affects vascular reactivity to contractile responses to phenylephrine (PHE) by blocking aortic ectonucleoside triphosphate diphosphohydrolase (E-NTPDase). Wistar rats of both sexes (260-300 g, 23 females, 7 males) were used. Experiments were performed before and after incubation of aortic rings with 3 µM Gd. Concentration-response curves to PHE (0.1 nM to 0.1 mM) were obtained in the presence and absence of endothelium, after incubation with 100 µM L-NAME, 10 µM losartan, or 10 µM enalaprilat. Gd significantly increased the maximum response (control: 72.3 ± 3.5; Gd: 101.3 ± 6.4%) and sensitivity (control: 6.6 ± 0.1; Gd: 10.5 ± 2.8%) to PHE. To investigate the blockade...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gadolinium; E-NTPDase; Adenosine; Angiotensin II; AT1receptor.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500010
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Gd-GLU toward NMR imaging: synthesis, characterization and breast cell uptake assay 60
Campos,Tarcisio Passos Ribeiro de; Dalmazio,Ilza; Augusti,Rodiney; Almeida,Iassudara Garcia.
Breast cancer cell uptake of Gd-metal is investigated based on the formation of coordinate compounds of gadolinium and glucose (Glu) molecules in solution. The hypothesis is that glucose helps Gd-internalization by complex formations constituted of Gd3+ coordinate to m-glucose molecules, whose valence was complemented by Cl- anions. Such a proposal is an insight toward a metabolic-dependent contrast-agent for cancer and inflammation in magnetic resonance image. A solution was prepared based on anhydrous d-glucose and gadolinium chloride (Gd-Glu). Uptake assays for MDA-MB-231(c231) cells were elaborated collecting incubated c231-cells with Gd-Glu and measuring metal-uptake and their concentrations by Nuclear Activation Analysis (NAA). The ionic solution was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glucose; Gadolinium; Breast cancer; In vitro uptake; MDA-MB-231.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100527
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Toxic effects of mercury, lead and gadolinium on vascular reactivity 56
Vassallo,D.V.; Simões,M.R.; Furieri,L.B.; Fioresi,M.; Fiorim,J.; Almeida,E.A.S.; Angeli,J.K.; Wiggers,G.A.; Peçanha,F.M.; Salaices,M..
Heavy metals have been used in a wide variety of human activities that have significantly increased both professional and environmental exposure. Unfortunately, disasters have highlighted the toxic effects of metals on different organs and systems. Over the last 50 years, the adverse effects of chronic lead, mercury and gadolinium exposure have been underscored. Mercury and lead induce hypertension in humans and animals, affecting endothelial function in addition to their other effects. Increased cardiovascular risk after exposure to metals has been reported, but the underlying mechanisms, mainly for short periods of time and at low concentrations, have not been well explored. The presence of other metals such as gadolinium has raised concerns about...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heavy metal toxicity; Vascular reactivity; Mercury; Lead; Gadolinium.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900016
Registros recuperados: 3
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