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From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases Genet. Mol. Biol.
Cussiol,José Renato Rosa; Soares,Bárbara Luísa; Oliveira,Francisco Meirelles Bastos de.
Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Yeast; Genome instability; DNA damage response; Cell cycle checkpoint; Kinase.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200302
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Spontaneous generation of diversity in Arachis neopolyploids (Arachis ipaënsis x Arachis duranensis)4x replays the early stages of peanut evolution. Repositório Alice
LEAL-BERTIOLI, S. C. M.; NASCIMENTO, E. F. M. B.; CHAVARRO, M. C. F.; CUSTÓDIO, A. R.; HOPKINS, M. S.; MORETZSOHN, M. de C.; BERTIOLI, D. J.; ARAUJO, A. C. G. de.
Tipo: Artigo de periódico Palavras-chave: Genome instability; Homoeologous recombination; SNPs; Morphology; Arachis; Cytogenetics; Domestication; Polyploidy.
Ano: 2021 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1134555
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The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells Biol. Res.
CARBALLO,JESÚS A; PINCHEIRA,JUANA; DE LA TORRE,CONSUELO.
Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells. After 72 h of recovery, root growth was reduced in a dose-dependent manner from 10 to 40 Gy, but not at 2.5 or 5 Gy doses. Flow cytometry plus TUNEL (TdT-mediated dUTP nick end labeling) showed that activation of apoptosis occurred only after 20 and 40 Gy of X-rays. Nevertheless, irrespective of the radiation dose, conventional flow cytometry showed that cells accumulated in G2 (4C DNA content). Simultaneously, the mitotic index fell, though a mitotic wave appeared later. Cell accumulation in G2 was transient and partially reversed by caffeine, thus it was...
Tipo: Journal article Palavras-chave: Apoptosis; Checkpoint adaptation; G2 DNA damage checkpoint; Genome instability; X-rays.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200015
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