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Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 10
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Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study BJID
Gales,Ana Cristina; Azevedo,Heber D; Cereda,Rosângela Ferraz; Girardello,Raquel; Xavier,Danilo Elias.
In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intraabdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbapenems; Gram-negative bacteria; Brazil.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600003
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Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia BJID
Villegas,Maria Virginia; Briceno,David Felipe; Ruiz,Sory Jamil; Furtado,Guilherme H; Nicolau,David P.
OBJECTIVES: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC distribution data to determine which of the tested carbapenem regimens provided the greatest opportunity for obtaining maximal pharmacodynamic (PD) activity. METHODS: The isolates studied were obtained from the COMPACT-COLOMBIA surveillance program conducted between February and November 2009. Antimicrobial susceptibility testing was conducted by broth microdilution method according to the CLSI guidelines. Doripenem, imipenem-cilastatin, and meropenem, were the modeled antibiotics. A 5,000 patient Monte...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug resistance; Bacterial; Gram-negative bacteria; Monte Carlo Method; Colombia; Pharmacology.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500001
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Effects of Food Additives on Susceptibility of Gram Negative Bacteria Derived from Dry-Fermented Sausage OAK
DORJ, Serjmyadag; SHIMADA, Kenichiro; SEKIKAWA, Mitsuo; 島田, 謙一郎; 関川, 三男.
This study examined the effects of food additives on gram-negative bacteria. The food additives used included synthetic antioxidants (butylated hydroxyanisole, BHA, and butylated hydroxytoluene, BHT), a curing agent and lactic acid with or without a cell-free supernatant (CFS) containing antimicrobial compounds of Lactobacillus sakei D-1001. The gram-negative bacteria were selected from dry-fermented sausages and cultured with different food additives for 18 h in nutrient broth, and then another 24 h with or without CFS adjusted (at pH 6.0) to inactivate lactic acid or not adjusted (at pH 4.0). BHA (0.1%) resulted in total viable cell inhibition following 18 h culture. A reduction in cell growth was observed in culture broths with 0.1% lactic acid and...
Palavras-chave: Food additive antimicrobial compounds; Gram-negative bacteria.
Ano: 2009 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2960
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Factors associated with bacteremia due to multidrug-resistant Gram-negative bacilli in hematopoietic stem cell transplant recipients BJMBR
Garnica,M.; Maiolino,A.; Nucci,M..
The epidemiology of bacteremia developing during neutropenia has changed in the past decade, with the re-emergence of Gram-negative (GN) bacteria and the development of multidrug resistance (MDR) among GN bacteria. We conducted a case-control study in order to identify factors associated with bacteremia due to multidrug-resistant Gram-negative (MDRGN) isolates in hematopoietic stem cell transplant recipients. Ten patients with MDRGN bacteremia were compared with 44 patients with GN bacteremia without MDR. Bacteremia due to Burkholderia or Stenotrophomonas sp was excluded from analysis (3 cases), because the possibility of intrinsical resistance. Infection due to MDRGN bacteria occurred in 2.9% of 342 hematopoietic stem cell transplant recipients....
Tipo: Info:eu-repo/semantics/other Palavras-chave: Hematopoietic stem cell transplant; Neutropenia; Gram-negative bacteria; Antibiotic resistance; Risk factors.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300010
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Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection BJID
Prata-Rocha,Mariana Lima; Gontijo-Filho,Paulo Pinto; Melo,Geraldo Batista de.
Multidrug-resistant (MDR) Acinetobacter baumannii (Acb) is a rapidly emerging pathogen in healthcare settings. The aim of this study was to evaluate the predictors of poor outcome in patients with MDR Acb. This is the first report documenting factors influencing survival in patients with MDR Acb in this tertiary hospital. This study is a prospective of the hospital epidemiology database. A total of 73 patients with 84 Acb isolates were obtained between August 2009 and October 2010 in this hospital. In the present study, the 30-day mortality rate was 39.7%. Of 84 Acb isolates, 50 (59%) were MDR, nine (11%) were pan-resistant, and 25 (30%) were non-MDR. The non-MDR isolates were used as the control group. The factors significantly associated with multidrug...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Multidrug-resistant; Acinetobacter baumannii; Gram-negative bacteria.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300004
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Increasing prevalence of extended-spectrum-betalactamase among Gram-negative bacilli in Latin America: 2008 update from the Study for Monitoring Antimicrobial Resistance Trends (SMART) BJID
Villegas,Maria Virginia; Blanco,Manuel Guzmán; Sifuentes-Osornio,Jose; Rossi,Flávia.
OBJECTIVES: This analysis of the Study for Monitoring Antimicrobial Resistance Trends (SMART) evaluated the susceptibility patterns of Enterobacteriaceae in Latin America in 2008, with emphasis on susceptibility trends of E. coli and K. pneumoniae. METHODS: Clinical isolates were recovered from intra-abdominal infections (IAI) from 23 centers in 10 Latin American countries. Isolates were sent to a central laboratory for confirmation of identification, antimicrobial susceptibility and ESBL testing, following the Clinical Laboratory Standards Institute (CLSI) guidelines. RESULTS: Of 1,003 Gram-negative bacilli collected from intra-abdominal infections, E. coli and K. pneumoniae were the most commonly isolated organisms, and 26.8% of E. coli and 37.7% of K....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbapenems; Beta-lactamases; Gram-negative bacteria; Drug resistance; ESBL.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100007
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Modified Carba NP test for the detection of carbapenemase production in gram-negative rods: optimized handling of multiple samples BJM
Campana,Eloiza H.; Chuster,Stephanie G.; Silva,Isadora R. da; Paschoal,Raphael P.; Bonelli,Raquel R.; Moreira,Beatriz M.; Picão,Renata C..
Abstract The modified Carba NP test presented here may be a valuable tool for laboratories interested in investigating a large number of carbapenemase-producing bacteria in a less-costly way. The test was evaluated against 48 carbapenemase-producing and carbapenemase-non-producing gram-negative bacteria. No false–positive results were obtained, but false-negative results were observed with OXA-23- and GES-carbapenemase-producing isolates. Aeromonas sp. are not testable by Modified Carba NP.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carbapenemases; Diagnostics; Gram-negative bacteria.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000200242
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Multidrug efflux systems in Gram-negative bacteria BJM
Moreira,Maria Aparecida Scatamburlo; Souza,Edmar Chartone de; Moraes,Célia Alencar de.
Multidrug efflux mechanisms in bacteria contribute significantly to intrinsic and acquired resistance to antimicrobial agents. Genome analysis have confirmed the broad distribution of these systems in Gram-negative as well as in Gram-positive bacteria. Among resistance mechanisms, the multidrug efflux system or pump deserves special attention, since a cell that has acquired it can simultaneously diminish or even suppress the susceptibility to a wide range of antimicrobials. The efflux system is mediated by transport proteins which confer resistance to toxic compounds. In Gram-negative bacteria, a tripartite efflux system is necessary to expel the drug to the outer medium: a protein localized in the cytoplasmic membrane; another in the periplasmatic space...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gram-negative bacteria; Multidrug efflux systems; Antimicrobials; Transport proteins; Multiresistance.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100003
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Phenol degradation and genotypic analysis of dioxygenase genes in bacteria isolated from sediments BJM
Tian,Mengyang; Du,Dongyun; Zhou,Wei; Zeng,Xiaobo; Cheng,Guojun.
Abstract The aerobic degradation of aromatic compounds by bacteria is performed by dioxygenases. To show some characteristic patterns of the dioxygenase genotype and its degradation specificities, twenty-nine gram-negative bacterial cultures were obtained from sediment contaminated with phenolic compounds in Wuhan, China. The isolates were phylogenetically diverse and belonged to 10 genera. All 29 gram-negative bacteria were able to utilize phenol, m-dihydroxybenzene and 2-hydroxybenzoic acid as the sole carbon sources, and members of the three primary genera Pseudomonas, Acinetobacter and Alcaligenes were able to grow in the presence of multiple monoaromatic compounds. PCR and DNA sequence analysis were used to detect dioxygenase genes coding for catechol...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Isolation and identification; Gram-negative bacteria; Substrate utilization; Dioxygenase genes; Phenol biodegradation.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000200305
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Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities Anais da ABC (AABC)
MONTE,ZENAIDE S.; SILVA,AMANDA M.; LIMA,GLÁUCIA M.S.; SILVA,TERESINHA G. DA; MARQUES,KARLA M.R.; RODRIGUES,MARIA D.; FALCÃO,EMERSON P.S.; MELO,SEBASTIÃO J..
ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Arylamidines; 2D spectroscopy; Gram-negative bacteria; Yeast; Cytotoxicity.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301051
Registros recuperados: 10
Primeira ... 1 ... Última
 

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