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	Provedor de dados BJPS (9) Repositório Alice (6) Thai Agricultural (2) Infoteca-e (2) Ciênc. Tecnol. Aliment. (1) Anais da ABC (AABC) (1) BABT (1) BJM (1) Ciência Rural (1) PAB (1) Mais... Autor ALMEIDA, S. D. B. (2) CERDEIRA, A. L. (2) FRANCO, D. A. S. (2) MATALLO, M. B. (2) MOURA, M. A. M. (2) Rolim,Clarice Madalena Bueno (2) ARADOTTIR, G. I. (1) Abrantes,Shirley de Mello Pereira (1) Acharya,Krishnendu (1) Aguiar,José Luiz Neves de (1) Albert,André Luis Mazzei (1) Alexandre Júnior,Veriano (1) Angsutorn Wasusun (1) Antunes,Marina Venzon (1) Ashfaq,Muhammad (1) BACCAN, M. (1) BIRKETT, M. A. (1) BOTTEON, J. E. (1) Baracat,Marcela Maria (1) Barin,Juliano Smanioto (1) Mais... Palavra-chave High performance liquid chromatography (25) Cromatografia (6) Análise química (3) HPLC (3) Cromatografia líquida de alta eficiência (2) Herbicida (2) Soja (2) Soybeans (2) Acetylsalicylic acid/determination in tablets (1) Afídeo (1) Aglycone (1) Agrochemicals (1) Albendazole (1) Alimento fermentado (1) Antibiotic residues (1) Antibiótico (1) Antiepileptic drugs/therapeutic monitoring (1) Antimicrobial (1) Antioxidant activity (1) Antioxidant capacity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (15) Artigo de periódico (3) PhysicalObject (2) Separatas (2) Anais e Proceedings de eventos (1) Boletim de Pesquisa e Desenvolvimento (INFOTECA-E) (1) Documentos (INFOTECA-E) (1) Mais... Ano 2021 (1) 2019 (2) 2018 (2) 2017 (3) 2016 (1) 2015 (1) 2014 (2) 2013 (2) 2012 (1) 2011 (3) 2009 (5) 2004 (1) 2002 (1) Mais... País Brazil (23) Thailand (2) Idioma Inglês (18) Português (5) Thailandês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 25 Primeira ... 1 2 ... Última A simple method for the quantification of diclofenac potassium in oral suspension by high-performance liquid chromatography with UV-detection BJPS Rubim,Alexandre Machado; Rubenick,Jaqueline Bandeira; Laporta,Luciane Varine; Rolim,Clarice Madalena Bueno. A rapid, simple and low cost method was developed to determine diclofenac potassium (DP) in oral suspension, using a reverse-phase column (C8, 150 mm x 4.6 mm, 5 µm), mobile phase containing methanol/buffer phosphate (70:30 v/v, pH 2.5), at a flow rate of 1.0 mL/min, isocratic method, and ultraviolet detection at 275 nm. A linear response (r = 1.0000) was observed in the range of 10.0-50.0 µg/mL. Validation parameters such as linearity, specificity, precision, accuracy and robustness were evaluated. The method presented precision (repeatability: relative standard deviation = 1.21% and intermediate precision: between-analyst = 0.85%). The specificity of the assay was evaluated by exposure of diclofenac potassium under conditions of stress such as... Tipo: Info:eu-repo/semantics/article Palavras-chave: High performance liquid chromatography; Diclofenac potassium; Oral suspension. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300021 Analysis of the composition of Brazilian propolis extracts by chromatography and evaluation of their in vitro activity against gram-positive bacteria BJM Sawaya,Alexandra C. H. F.; Souza,Kirllian S.; Marcucci,Maria C.; Cunha,Ildenize B.S.; Shimizu,Mario T.. Brazilian propolis from São Paulo state was submitted to extraction using several solvents, resulting in extracts with different composition. These extracts were submitted to Thin Layer Chromatography (TLC). Bioauthographic analysis of the TLC plates identified fractions with inhibitory activity, which were then analysed by High Performance Liquid Chromatography (HPLC). In vitro assays, commonly used to evaluate the activity of propolis against Gram-positive bacteria, were compared to determine which rendered the most consistent results. The bactericidal activity of these extracts were analysed by Serial Dilution in Tubes and Agar Plate Diffusion. Serial Dilution in Tubes obtained the most consistent results, with the Minimal Bactericidal Concentration of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propolis; Thin layer chromatography; Bioauthography; High performance liquid chromatography; Extraction methods; Minimal bactericidal concentration. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000100017 Assessment of in vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin BJPS Vicentini,Fabiana Testa Moura de Carvalho; Georgetti,Sandra Regina; Bentley,Maria Vitória Lopes Badra; Fonseca,Maria José Vieira. To be effective against the oxidative damages induced by UVB irradiation in the skin, the drug needs to release from the formulation in which it was incorporated and reach the skin layers where the ROS are generated. Thus, it is very important the development of a robust and sensitive methodology to extract and quantify in different skin layers the antioxidant agent delivered from topical formulations. Therefore, in the present work suitable methods to extract and quantify quercetin in skin samples and receptor phase after in vitro penetration studies were developed. The results demonstrated that the recovery from two different layers of skin, the SC and [E+D], using two different methods of quantification (DPPH• assay and HPLC, respectively), was 93.8 %... Tipo: Info:eu-repo/semantics/article Palavras-chave: Topical formulations/analysis; Quercetin/quantification; Quercetin/extraction; Quercetin/liberation; Skin penetration in vitro/study; High performance liquid chromatography; DPPH•. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200022 Changes in the isoflavone profile and in the chemical composition of tempeh during processing and refrigeration. Repositório Alice FERREIRA, M. P.; OLIVEIRA, M. C. N. de; MANDARINO, J. M. G.; SILVA, J. B. da; IDA, E. I.; CARRÃO-PANIZZI, M. C.. The objective of this work was to analyze changes in the isoflavone profile, determined by high performance liquid chromatography, at different processing stages and after refrigeration of tempeh. For tempeh production, clean soybean grains from cultivars BR 36 (low isoflavone content) and IAS 5 (high) were dehulled, and the separated cotyledons were hydrated and then cooked in boiling water for 30 min. Spores of the fungus Rhizopus microsporus var. oligosporus were inoculated in the cooked and cooled cotyledons, and incubated at 32ºC for 6, 12, 18, and 24 hours in perforated polypropylene bags, for fermentation. The resulting tempeh was stored at 4ºC for 6, 12, 18, and 24 hours. After 24‑hour fermentation, isoflavone glucosides were 50% reduced,... Tipo: Artigo de periódico Palavras-chave: Soja; Nutrição humana; Alimento fermentado; Fermentação; Análise química; Composição química; Composição de alimento; Cromatografia; Soybeans; Functional foods; High performance liquid chromatography. Ano: 2011 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/915552 Changes in the isoflavone profile and in the chemical composition of tempeh during processing and refrigeration PAB Ferreira,Márcia Pires; Oliveira,Maria Cristina Neves de; Mandarino,José Marcos Gontijo; Silva,Josemeyre Bonifácio da; Ida,Elza Iouko; Carrão-Panizzi,Mercedes Concórdia. The objective of this work was to analyze changes in the isoflavone profile, determined by high performance liquid chromatography, at different processing stages and after refrigeration of tempeh. For tempeh production, clean soybean grains from cultivars BR 36 (low isoflavone content) and IAS 5 (high) were dehulled, and the separated cotyledons were hydrated and then cooked in boiling water for 30 min. Spores of the fungus Rhizopus microsporus var. oligosporus were inoculated in the cooked and cooled cotyledons, and incubated at 32ºC for 6, 12, 18, and 24 hours in perforated polypropylene bags, for fermentation. The resulting tempeh was stored at 4ºC for 6, 12, 18, and 24 hours. After 24-hour fermentation, isoflavone glucosides were 50% reduced, and the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rhizopus microsporus var. oligosporus; Aglycone; Fermentation; Functional food; High performance liquid chromatography; Malonyl. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2011001100018 Chemical composition and bioactivity of methanolic extract obtained from Lepista sordida BJPS Acharya,Krishnendu; Ghosh,Sandipta; Biswas,Rhituparna. The present study aimed at the evaluation of chemical composition and bioactive potential of methanolic extract obtained from Lepista sordida in terms of antioxidative and antimicrobial efficacy. The macrofungus is recognized for its high nutritional value and medicinal properties. However, to the best of our knowledge bioactivity of its methanolic extract is yet to be explored. In this investigation, quantitative analysis of mycochemicals revealed the extract contained significant amount of phenolic compounds such as phenols and flavonoids. Ascorbic acid was found in higher amount than β carotene and lycopene which were present in vestigial amounts. A phenolic profile was also determined using high performance liquid chromatography that further confirmed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobial; Free radical scavenger; High performance liquid chromatography; Mycotaxon; Mycochemicals. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100600 Comparison of microbiological assay and HPLC-UV for determination of fluconazole in capsules BJPS Queiroz,Kelly Marques; Silva,Maria-Luiza Martins; Prado,Nathália Duque; Lima,Paulo Marcelo Andrade; Diniz,Rosiane Dias Lopes; César,Isabela Costa; Pianetti,Gerson Antônio; Santos,Daniel Assis. The development of a specific agar diffusion bioassay for the quantitative determination of fluconazole formulated in capsules was carried out using a strain of Candida albicans ATCC 18804 as the test organism. A prospective validation of the method showed adequate linearity (r²=0.9995), precision (R.S.D. = 4.0% for intra-day and 4.5% for inter-day precision) and accuracy (mean recovery = 102.9%). High performance liquid chromatography was chosen as a comparison method for the fluconazole determination. The contents of fluconazole determined by both methods, for four capsule samples, showed a strong correlation, confirmed by Pearson's correlation coefficient value (r = 0.9884). The bioassay is a suitable method for both research and pharmaceutical industry... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluconazole/quantitative determination; Microbiological assay/agar diffusion; High performance liquid chromatography. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400012 Cytotoxicity and antioxidant activity of goldenberry extracts obtained with high intensity ultrasound Ciência Rural Codevilla,Cristiane Franco; Tischer,Bruna; Gindri,Amanda Leitão; Nogueira-Librelotto,Daniele Rubert; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Rolim,Clarice Madalena Bueno; Zepka,Leila Queiroz; Menezes,Cristiano Ragagnin de. ABSTRACT: The high intensity ultrasound-assisted extraction (HIU) is one of the most simple, quick and efficient techniques for the extraction of phenolic and other antioxidant compounds from plants. This is the first application of HIU for the extraction of these compounds from goldenberry fruit. The HIU and conventional extraction techniques showed similar results regarding to phenolic compounds and antioxidant capacity. However, the time required for HIU extraction (5min) was 24 times lower than conventional extraction (120min). Phenolic compounds reported were chlorogenic acid, caffeic acid and rutin. In vitro cytotoxicity assays were used for evaluation of extracts and the results showed that in a wide range of concentration, the extract maintains... Tipo: Info:eu-repo/semantics/article Palavras-chave: Goldenberry; Sonication; Antioxidant capacity; Cytotoxicity; High performance liquid chromatography. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000200752 Determinação de agrotóxicos e ocratoxina A em café arábica sob diferentes níveis de torrefação. Infoteca-e ROSA, J. S. da; FREITAS-SILVA, O.; CAMPOS, R. da S.; CASTRO, I. M. de; TEIXEIRA, A. da S.. O café é a segunda maior commodity do mundo e tamanha importância faz do café uma matriz alimentar muito estudada. A necessidade de incremento na produtividade dessa cultura, porém, pode aumentar o uso de alguns agrotóxicos em sistemas de produção de café. Da mesma forma, as práticas de colheita e processamento pós-colheita do café estão diretamente relacionadas à contaminação dos grãos por fungos micotoxigênicos. Rastrear a presença destes dois tipos de contaminantes em amostras de café Arábica comum (com diferentes teores de grãos defeituosos) e submetidos a diferentes níveis de torra foi o objetivo deste trabalho. Os agrotóxicos foram analisados pelo método multirresíduo, por espectrometria de massas sequencial, e a ocratoxina A, por cromatografia... Tipo: Boletim de Pesquisa e Desenvolvimento (INFOTECA-E) Palavras-chave: Contaminante; Cromatografia líquida de alta eficiência; Micotoxina; Coffea Arábica; Tecnologia de Alimento; Espectrometria; Cromatografia; Food technology; Vegetable products; High performance liquid chromatography; Mycotoxins; Mass spectrometry; Poisoning; Agrochemicals. Ano: 2019 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1112112 Development of a new analytical method for determination of acetylsalicylic and salicylic acids in tablets by reversed phase liquid chromatography BJPS Aguiar,José Luiz Neves de; Leandro,Katia Christina; Abrantes,Shirley de Mello Pereira; Albert,André Luis Mazzei. Acetylsalicylic acid (AAS) is a drug utilized as analgesic, anti-inflammatory, and antipyretic medication, available worldwide and commonly used in Brazil. Salicylic acid (AS) is a precursor in AAS synthesis and is also produced during its degradation. The official United States Pharmacopoeia (USP) suggests the determination of these drugs by high performance liquid chromatography (HPLC), with ultraviolet detection, but this method has neither a high sensitivity (S AAS=0.12 mAbs/(μg/mL) and S AS=0.48 mAbs/(μg/mL)) nor resolution (Rs=1.61). The purpose of this study was to develop a new more adequate, accurate method by liquid phase chromatography than the current official methodology, and to use this new method in the determination of the tenors of... Tipo: Info:eu-repo/semantics/article Palavras-chave: High performance liquid chromatography; Acetylsalicylic acid/determination in tablets; Salicylic acid/determination in tablets; Tablets/quantitative analysis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400016 DIMBOA levels in hexaploid Brazilian wheat are not associated with antibiosis against the cereal aphids Rhopalosiphum padi and Sitobion avenae. Repositório Alice PEREIRA, J. F.; SARRIA, A. L. F.; POWERS, S. J.; ARADOTTIR, G. I.; CAULFIELD, J. C.; MARTIN, J.; SMART, L. E.; PICKETT, J. A.; BIRKETT, M. A.; PEREIRA, P. R. V. da S.. Tipo: Separatas Palavras-chave: Ácidos hidroxâmicos; Trigo; Afídeo; Wheat; Aphidoidea; Hydroxamic acids; High performance liquid chromatography. Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1079746 Diterpenes biochemical profile and transcriptional analysis of cytochrome P450s genes in leaves, roots, flowers, and during Coffea arabica L. fruit development. Repositório Alice IVOMOTO, S. T.; SAKURAY, L. M.; FERREIRA, L. P.; KITZBERGER, C. S. G.; SCHOLZ, M. B. S.; POT, D.; LEROY, T.; VIEIRA, L. G. E.; DOMINGUES, D. S.; PEREIRA, L. F. P.. Lipids are among the major chemical compounds present in coffee beans, and they affect the flavor and aroma of the coffee beverage. Coffee oil is rich in kaurene diterpene compounds, mainly cafestol (CAF) and kahweol (KAH), which are related to plant defense mechanisms and to nutraceutical and sensorial beverage characteristics. Despite their importance, the final steps of coffee diterpenes biosynthesis remain unknown. To understand the molecular basis of coffee diterpenes biosynthesis, we report the content dynamics of CAF and KAH in several Coffea arabica tissues and the transcriptional analysis of cytochrome P450 genes (P450). We measured CAF and KAH concentrations in leaves, roots, flower buds, flowers and fruit tissues at seven developmental stages... Tipo: Artigo de periódico Palavras-chave: Cafestol; Kahweol; RT-qPCR; Café; Gene expression; High performance liquid chromatography. Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1083355 Enantioselective metabolism of hydroxychloroquine employing rats and mice hepatic microsomes BJPS Cardoso,Carmem Dickow; Bonato,Pierina Sueli. Hydroxychloroquine (HCQ) is an important chiral drug used, mainly, in the treatment of rheumatoid arthritis, systemic lupus erythematosus and malaria, and whose pharmacokinetic and pharmacodynamic properties look to be stereoselective. Respecting the pharmacokinetic properties, some previous studies indicate that the stereoselectivity could express itself in the processes of metabolism, distribution and excretion and that the stereoselective metabolism looks to be a function of the studied species. So, the in vitro metabolism of HCQ was investigated using hepatic microsomes of rats and mice. The microsomal fraction of livers of Wistar rats and Balb-C mice was separated by ultracentrifugation and 500 μL were incubated for 180 minutes with 10 μL of racemic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hydroxychloroquine; Stereoselective metabolism/in vitro study; High performance liquid chromatography; Capillary electrophoresis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400008 Green method by diffuse reflectance infrared spectroscopy and spectral region selection for the quantification of sulphamethoxazole and trimethoprim in pharmaceutical formulations Anais da ABC (AABC) Silva,Fabiana E.B. da; Flores,Érico M.M.; Parisotto,Graciele; Müller,Edson I.; Ferrão,Marco F.. An alternative method for the quantification of sulphametoxazole (SMZ) and trimethoprim (TMP) using diffuse reflectance infrared Fourier-transform spectroscopy (DRIFTS) and partial least square regression (PLS) was developed. Interval Partial Least Square (iPLS) and Synergy Partial Least Square (siPLS) were applied to select a spectral range that provided the lowest prediction error in comparison to the full-spectrum model. Fifteen commercial tablet formulations and forty-nine synthetic samples were used. The ranges of concentration considered were 400 to 900 mg g-1SMZ and 80 to 240 mg g-1 TMP. Spectral data were recorded between 600 and 4000 cm-1 with a 4 cm-1 resolution by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). The proposed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemometrics; Diffuse reflectance infrared Fourier transform spectroscopy; Green analytical method; High performance liquid chromatography; Interval partial least squares (iPLS); Synergy partial least squares (siPLS). Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100001 Método de análise de florfenicol e florfenicol amina em água por injeção direta e cromatografia líquida acoplada a espectrometria de massas. Repositório Alice MORANDI, J.; TAVARES, M. M.; FERRACINI, V. L.. Resumo: Métodos para determinação de produtos sintéticos em amostras aquosas normalmente requerem várias etapas de preparação das amostras, como extração, clean up e concentração. Portanto é muito importante desenvolver métodos analíticos mais simples, mais econômicos e com baixo impacto ao meio ambiente. O objetivo foi testar um método para detecção multiresíduos de dois antibióticos baseado em cromatografia líquida acoplada à espectrometria de massa (UPLC - ESI -MS/MS), operado em modo positivo de ionização para o florfenicol amina e modo negativo para o florfenicol, sem concentração e/ou clean up. O método por injeção direta e sem clean up além de conseguir economia de reagentes e solventes, minimiza o desperdício, o que resulta em vantagens no ponto de... Tipo: Anais e Proceedings de eventos Palavras-chave: Detecção de antibiótico; Resíduos em água; Injeção direta; Cromatografia líquida de ultra eficiência.; Análise Química; Método de Análise; Cromatografia; Antibiótico; Resíduo; High performance liquid chromatography; Antibiotic residues; Water analysis. Ano: 2021 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1138619 Monitoramento do ácido chiquímico no manejo de plantas daninhas com glifosato em pomar comercial de citros. Repositório Alice MATALLO, M. B.; ALMEIDA, S. D. B.; CERDEIRA, A. L.; FRANCO, D. A. S.; LUCHINI, L. C.; MOURA, M. A. M.; DUKE, S. O.. Com o objetivo de verificar o acúmulo de ácido chiquímico em plantas de laranja pêra (Citrus sinensis) num pomar comercial manejado com glifosato, um herbicida sistêmico de amplo espectro, foram coletadas amostras na Fazenda Jequitibá, tradicional no cultivo de citros, situada no Município de Santo Antônio de Posse, SP. O produtor aplicou de forma convencional Roundup® Original a 1.440 g.ha-1 de equivalente ácido (e.a.) do sal de isopropilamino de glifosato em 19/12/2006 na entrelinha de 15 plantas, deixando outras cinco como testemunha. A reaplicação de glifosato a 1.260 g.ha-1 de e.a. foi realizada em 2/4/2007. Em ambos os casos, imediatamente antes da aplicação e aos 3, 7, 10, 15, 20 e 35 dias após, foram coletadas 20 folhas de cada planta tanto da área... Tipo: Artigo de periódico Palavras-chave: Herbicidas; Chiquimato; CLAE; Herbicida; Laranja pera; Cromatografia; Herbicides; Oranges; High performance liquid chromatography. Ano: 2011 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/901527 Monitoring and risk assessment due to presence of heavy metals and pesticides in tea samples Ciênc. Tecnol. Aliment. YAQUB,Ghazala; ILYAS,Fizza; IDREES,Muniba; MARIYAM,Vania. Abstract Tea is one of the most consumed beverages after water, but unfortunately the application of pesticides and heavy metals in crops make it unsafe for use. This research was conducted to evaluate the risk of heavy metals and pesticides in samples of natural source tea (gardens) and different local market brands. High Performance Liquid Chromatography was used to detect pesticides, Bifenthrin, Lambda chalothrin, Imadachloroprid, Dichlorovas, Glyphosate and Emamectin. Heavy metals such as Zinc, Iron, Chromium, copper, manganese and cobalt were determined by atomic absorption spectroscopy. The value of HRI and THQ was still calculated for some exceeded samples. From results obtained some of the tea samples were contaminated from with heavy metals i.e.,... Tipo: Info:eu-repo/semantics/article Palavras-chave: High performance liquid chromatography; Health risk index; Target hazard quotient. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612018000400625 Quantificação de ácidos fenólicos constitutivos da soja [Glycine max (L.) Merrill] por cromatografia líquida de alta eficiência (CLAE). Infoteca-e FRIGHETTO, R. T. S.; BACCAN, M.. O escopo do presente trabalho é a disponibilização de um método de análise para a determinação quantitativa de ácidos fenólicos constitutivos das folhas de soja. O método é uma adaptação baseada em Evaristo e Leitão (2001) para mistura da fase móvel e o comprimento de onda determinado por Ruhland et al (2005). Tipo: Documentos (INFOTECA-E) Palavras-chave: Ácidos fenólicos; Cromatografia líquida de alta eficiência; Cromatografia; Análise química; Soja; High performance liquid chromatography; Soybeans; Phenolic acids. Ano: 2012 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/939049 Sensory evaluation of albendazole suspensions BABT Fregonezi-Nery,Marlene Maria; Prudencio-Ferreira,Sandra Helena; Kedor,Érika Maria Rosa; Baracat,Marcela Maria; Brinholi,Francis Fregonezi. Sensory analysis was used in the albendazole suspension stability study. Three formulations were prepared and stored for 1, 3, and 6 months at 4 ±1, 26 ±1, 37, 50 and 65 ºC. Samples were evaluated through the difference from control sensory test using 24 trained judges in individual cabins. Although albendazole content was not altered in the conditions studied, sensory test showed differences between control and stored samples, except for one of the formulations stored under refrigeration for one month. These results have shown that the sensory evaluation is an important tool for quality control of pharmaceutical preparations, in association with chemical, physicochemical and microbiological tests. Tipo: Info:eu-repo/semantics/article Palavras-chave: Albendazole; Sensory analysis; High performance liquid chromatography. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000600009 Stability indicating RP-HPLC method for simultaneous determination of gatifloxacin and dexamethasone in binary combination BJPS Razzaq,Syed Naeem; Ashfaq,Muhammad; Khan,Islam Ullah; Mariam,Irfana; Razzaq,Syed Saleem; Mustafa,Ghulam; Zubair,Muhammad. Abstract In this study, conditions were optimized for development of a simple RP-HPLC method for simultaneous analysis of gatifloxacin and dexamethasone in different matrices like pharmaceuticals, human serum and urine. Good separation of gatifloxacin and dexamethasone from the induced degradation products was accomplished using C8 as stationary phase; 0.02 M phosphate buffer (pH 3.0) and methanol (42:58 v/v) as mobile phase. The concentration was measured with DAD at 270 nm. Linearity was observed in the range of 0.000040-0.000280 mol/L for gatifloxacin (r2≥0.999) and 0.000013-0.000091 mol/L for dexamethasone (r2≥0.999). Both the analyte peaks were completely separated from the peaks of induced degradation products as indicated by the peak purity index... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gatifloxacin; Dexamethasone; High performance liquid chromatography; Validation; Plasma; Degradation products.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100607 Registros recuperados: 25 Primeira ... 1 2 ... Última

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