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| Registros recuperados: 13 | |
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| Viana,Osnir de Sá; Medeiros,Flávia Patrícia Morais; Grangeiro-Júnior,Severino; Albuquerque,Miracy Muniz; Soares,Mônica Felts La Roca; Soares-Sobrinho,José Lamartine; Alves,Lariza Darlene Santos; Rolim,Larissa Araújo; Silva,Keyla Emanuelle Ramos da; Rolim-Neto,Pedro José. |
| Efavirenz is a reverse transcriptase non analog nucleoside inhibitor used to treat HIV infections. A simple assay method by high performance liquid chromatography was developed and validated for efavirenz tablets. The physical chemical characteristics of efavirenz were investigated to developing the method. The method was validated observing the parameters described in USP 29. Analyses were performed by an ultraviolet detector at a 252 nm wavelength, on a reverse-phase column (C18, 250 mm x 3.9 mm, 10 μm), using an isocratic mobile phase containing acetonitrile/water/orthophosphoric acid (70:30:0.1). The validation parameters used were: selectivity, linearity, precision, accuracy, robustness, detection and quantification limits, and all resulting data were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Efavirenz/tablet assay; High performance liquid chromatography/quantitative analysis. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100012 |
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| Kommana,Ramakrishna; Kannabattula,Gouthami; Gurrala,Sunitha; Yeradesi,Venkat Raj; Durga,Panikumar Anumolu. |
| A simple, specific, precise, accurate, linear, rapid, economic and validated stability indicating an RP-HPLC method for the simultaneous quantification of cefepime and tazobactam in a dry injection dosage form has been developed. Separation was performed on a 5 µm ACE C18column with phosphate buffer, pH adjusted to 4.5 with phosphoric acid: methanol (70:30) at a flow rate of 1 mL/min and at a temperature of 25 °C. Regression analysis showed linearity at a detector wavelength of 290 nm in the range of 200-600 μg/mL for cefepime and 25-75 μg/mL for tazobactam. All of the analytes were adequately resolved with acceptable tailing. The percentage content found for cefepime was 99.98% and of tazobactam was 99.49% in the parenteral formulation. The method was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High performance liquid chromatography/quantitative analysis; Cefepime/quantificação; Tazobactam/quantificação; Dry injection formulation/quantitative analysis; Pharmaceutical formulations/degradation studies. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400895 |
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| César,Isabela da Costa; Pianetti,Gerson Antônio. |
| The quantitation of artemether in both pharmaceutical raw material and injections was carried out by high performance liquid chromatography (HPLC) with ultraviolet detection. A Zorbax C18 column (150 x 4.6 mm; 5 μm), at 30 °C, and a mobile phase composed of acetonitrile and water (70:30), at a flow rate of 1ml/min, were used. The detection wavelength was 216 nm and the injection volume was 20 μL. The method proved to be linear (r²=0.9999), precise (RSD < 20% for intra-day and inter-day precision), accurate and selective regarding possible impurities and excipients of the samples. The detection and quantitation limits were 8 μg/mL and 25 μg/mL, respectively. The artemether content obtained in the raw material analysis was 99.26% and in the injections,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Artemether/quantitation; High performance liquid chromatography/quantitative analysis; Antimalarials. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400018 |
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| Silva,Viviane Benevenuti; Galdos,Angel Arturo Gaona; Mothe,Cintia Maria Alves; Pallastrelli,Michele Bacchi; Prado,Maria Segunda Aurora; Singh,Anil Kumar; Kedor-Hackmann,Erika Rosa Maria; Santoro,Maria Inês Rocha Miritello. |
| A simple, rapid, economical and reliable high performance liquid chromatographic method has been developed and successfully applied in simultaneous determination of ethinyl estradiol and drospirenone in coated tablets. The HPLC method was performed on a LiChroCART® 100RP column (125x4 mm i.d., 5 µm) with acetonitrile:water 50:50 (v/v) as mobile phase, pumped at a flow rate of 1.0 mL.min-1. The fluorescence detection for ethinyl estradiol was made at λex= 280 nm and λem= 310 nm and a UV detection for drospirenone was made at 200 nm. The elution time for ethinyl estradiol and drospirenone were 4.0 and 5.7 min, respectively. The method was validated in accordance to USP 34 guidelines. The proposed HPLC method presented advantages over reported methods and is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coated tablets/quantitative analysis; High performance liquid chromatography/quantitative analysis; Ethinyl estradiol/quantitative determination; Drospirenone/quantitative determination; Fluorescence detection; UV detection. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300013 |
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| Scremin,Amarilis; Piazzon,Monika; Silva,Marcos Antonio Segatto; Kuminek,Gislaine; Correa,Giane Márcia; Paulino,Niraldo; Cardoso,Simone Gonçalves. |
| Deflazacort (DFZ) is a glucocorticoid used as an anti-inflammatory and immunosuppressant drug. No official methods are available for DFZ determination in pharmaceutical formulations. The objective of this study was to develop, validate and compare spectrophotometric (UV and colorimetric) and high-performance liquid chromatography (HPLC) methods, for the quantitative determination of DFZ in tablets and oral suspension. For the UV method, ethanol was used as the solvent, with detection at 244 nm. The colorimetric method was based on the redox reaction with blue tetrazolium in alkaline medium, with detection at 524 nm. The method by HPLC was carried out using a C18 column, mobile phase consisting of acetonitrile:water (80:20, v/v) with a flow rate of 1.0 mL... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Deflazacort/quantitative determination; High performance liquid chromatography/quantitative analysis; Spectrophotometry/quantitative analysis; Medicines/quantitative analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200015 |
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| Ianiski,Francine Rodrigues; Laporta,Luciane Varini; Rubim,Alexandre Machado; Luchese,Cristiane. |
| abstract A method to ensure that an analytical method will produce reliable and interpretable information about the sample must first be validated, making sure that the results can be trusted and traced. In this study, we propose to validate an analytical high performance liquid chromatography (HPLC) method for the quantitation of meloxicam loaded PEGylated nanocapsules(M-PEGNC). We performed a validation study, evaluated parameters including specificity, linearity, quantification limit, detection limit, accuracy, precision and robustness. PEGylated nanocapsules were prepared by interfacial deposition of preformed polymer, and the particle size, polydispersity index, zeta potential, pH value and encapsulation efficiency were characterized. The proposed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High performance liquid chromatography/quantitative analysis; Meloxicam/determination; PEGylated nanocapsules/quality control; Nanoparticles; Poly(ethylene glycol).. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400823 |
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| Registros recuperados: 13 | |
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