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	Provedor de dados BJMBR (2) Biological Sciences (1) Autor Adjafre, Beatriz Lima (1) Alves, Ana Paula Negreiros Nunes (1) Assreuy, Ana Maria Sampaio (1) Barbosa,A.L.R. (1) Branco,L.G.S. (1) Moraes,M.O. (1) Mota, Mário Rogério Lima (1) Nascimento,C.G.O. (1) Oliveira,G.J. (1) Pinheiro,C.A. (1) Pires, Alana de Freitas (1) Quinet, Yves (1) Ribeiro,R.A. (1) Sousa, Évilla Rayanne Oliveira (1) Souza,M.H.L.P. (1) Torres,J.N.L. (1) Vale,M.L. (1) Mais... Palavra-chave Hypernociception (3) Antinociception (1) Carbon monoxide (1) Carrageenan (1) DqV (1) Formalin (1) Leukocyte infiltrate (1) Nitric oxide (1) Nociception (1) Scar (1) Walker 246 tumor-bearing rats (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2012 (1) 2009 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Antinociception synergy between the peripheral and spinal sites of the heme oxygenase-carbon monoxide pathway BJMBR Nascimento,C.G.O.; Branco,L.G.S.. We have shown that the peripheral and spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase-cGMP pathways play an important role in antinociception in the rat experimental formalin model. Our objective was to determine if there is synergism between peripheral (paw) and spinal HO-CO pathways in nociception. Rats were handled and adapted to the experimental environment for a few days before the formalin test, in which 50 µL of a 1% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The animals were then observed for 1 h and the frequency of flinching behavior was taken to represent the nociceptive response. Thirty minutes before the test, rats were pretreated with intrathecal injections of the HO... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nociception; Carbon monoxide; Formalin; Hypernociception; Antinociception. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100020 Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats BJMBR Barbosa,A.L.R.; Pinheiro,C.A.; Oliveira,G.J.; Torres,J.N.L.; Moraes,M.O.; Ribeiro,R.A.; Vale,M.L.; Souza,M.H.L.P.. Implantation of Walker 256 tumor decreases acute systemic inflammation in rats. Inflammatory hyperalgesia is one of the most important events of acute inflammation. The L-arginine/NO/cGMP/K+ATP pathway has been proposed as the mechanism of peripheral antinociception mediated by several drugs and physical exercise. The objective of this study was to investigate a possible involvement of the NO/cGMP/K+ATP pathway in antinociception induced in Walker 256 tumor-bearing male Wistar rats (180-220 g). The groups consisted of 5-6 animals. Mechanical inflammatory hypernociception was evaluated using an electronic version of the von Frey test. Walker tumor (4th and 7th day post-implantation) reduced prostaglandin E2- (PGE2, 400 ng/paw; 50 µL; intraplantar injection)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Walker 246 tumor-bearing rats; Hypernociception; Nitric oxide; Carrageenan. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600009 Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model Biological Sciences Assreuy, Ana Maria Sampaio; Adjafre, Beatriz Lima; Sousa, Évilla Rayanne Oliveira; Alves, Ana Paula Negreiros Nunes; Pires, Alana de Freitas; Quinet, Yves; Mota, Mário Rogério Lima. Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ‘‘Serra de Maranguape’’ (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone,... Tipo: Info:eu-repo/semantics/article Palavras-chave: DqV; Hypernociception; Leukocyte infiltrate; Scar. Ano: 2020 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/47680 Registros recuperados: 3 Primeira ... 1 ... Última

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