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Correlation between interleukin-18promoter -607C/A polymorphism and susceptibility to ischemic stroke BJMBR
Lu,Jian-xia; Lu,Zhong-qian; Zhang,Shao-lan; Zhi,Juan; Chen,Zheng-ping; Wang,Wan-xiang.
Single nucleotide polymorphisms in the promoter region ofinterleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between theIL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chain reaction with sequence-specific primers. Significant differences were observed by the χ2 test in the -607C/A (rs1946518) genotype and allele frequencies between cases and controls (P < 0.05). Furthermore, after excluding for age, gender, smoking status, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: IL-18; Polymorphism; Ischemic stroke; Correlation.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600502
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Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population BJID
Wang,Changyuan; Wei,Li; Chu,Weilin; Yu,Haiyang; Yu,Xinjuan; Li,Chunxia.
ABSTRACT Host immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexual contact (NSC). In addition, 360 healthy volunteers were enrolled as controls. SNPs at positions −607C/A and −137G/C in IL-18 promoter were analyzed. Comparing CA patients to healthy controls, no dominant relevance was found between the IL-18 promoter −607 C/A or −137G/C polymorphisms and the CA disease either...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Condyloma acuminatum; Human papillomavirus; Cytokine; Single nucleotide polymorphism; IL-18.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388
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Extremely elevated IL-18 levels may help distinguish systemic-onset juvenile idiopathic arthritis from other febrile diseases BJMBR
Xia,Y.; Cui,P.; Li,Q.; Liang,F.; Li,C.; Yang,J..
The aim of this research was to explore whether IL-18 can be a serological marker for the diagnosis of systemic-onset juvenile idiopathic arthritis (sJIA). A total of 23 sJIA patients (13 males, median age 8.2), 20 acute lymphoblastic leukemia (ALL) patients, 18 patients with severe infections (SIF), 26 Kawasaki disease (KD) patients, 18 juvenile idiopathic arthritis (JIA) patients, and 25 healthy control patients were selected for this study. Enzyme-linked immunosorbent assays (ELISAs) were used to determine the serum concentrations of the S100A8, S100A9, and IL-6 proteins. The serum IL-18 levels were detected by a cytometric bead array (CBA). The serum IL-6 concentrations in various disease groups were significantly higher than that in the healthy...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic-onset juvenile idiopathic arthritis (sJIA); Serological markers; IL-18; S100A8/S100A9.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200703
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Genetic polymorphisms of Interleukin-18 are not associated with allograft function in kidney transplant recipients Genet. Mol. Biol.
Nascimento,Wenna Gleyce Araújo do; Cilião,Daiani Alves; Genre,Julieta; Gondim,Dikson Dibe; Alves,Renata Gomes; Hassan,Neife Deghaide; Lima,Francisco Pignataro; Pereira,Maurício Galvão; Donadi,Eduardo Antônio; Crispim,Janaina Cristiana de Oliveira.
Interleukin 18 (IL-18) is a proinflammatory cytokine that plays a role in host defense by upregulating both innate and acquired immune responses. Analysis of IL 18 polymorphisms may be clinically important since their roles have been recognized in a variety of inflammatory and autoimmune disorders. However, the role of this cytokine polymorphisms in kidney transplant still remains unclear. In this study, we evaluated the associations between IL 18 polymorphisms and graft function assessed by creatinine clearance in kidney transplant recipients. A total of 82 kidney transplant recipients and 183 healthy controls were enrolled, and frequencies of alleles, genotypes and haplotypes for IL 18 polymorphisms were determined and compared with creatinine clearance....
Tipo: Info:eu-repo/semantics/article Palavras-chave: IL-18; -607C/A; -137C/G; Kidney transplant.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300005
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Peritoneal and serum interleukin-18 levels are not increased in women with minimum or mild endometriosis BJMBR
Glitz,C.; Souza,C.A.; Rodini,G.P.; Genro,V.; Bilibio,J.P.; Senger,M.; Cunha-Filho,J.S..
Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 family. Endometriosis is strongly associated with sub-fertility, and affects about 15% of women of reproductive age. IL-18 may favor the progression of endometriosis. The objective of the present study was to determine the concentration of IL-18 in the serum and peritoneal fluid of infertile women with endometriosis. Forty infertile and 25 fertile women were screened in a teaching hospital. Thirty-four infertile patients with minimal or mild endometriosis and 22 fertile controls were enrolled in the study. The primary outcome was the estimate of IL-18 levels and the secondary outcome was the correlation between serum and peritoneal levels of IL-18. There were no differences between the two...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Endometriosis; IL-18; Peritoneal fluid; Infertility.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100007
Registros recuperados: 5
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