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ANTIMICROBIAL PEPTIDES, AN ALTERNATIVE TO COMBAT BACTERIAL RESISTANCE Acta biol.Colomb.
MEJÍA-ARGUETA,Euridice Ladisu; SANTILLÁN-BENÍTEZ,Jonnathan Guadalupe; ORTIZ-REYNOSO,Mariana.
ABSTRACT Antimicrobial peptides (AMPs) of higher organisms have been studied for the past 25 years, and their importance as components of innate immunity is now well established. The essential simplicity of their chemical structure, along with the lower likelihood of developed resistance compared to conventional antibiotics, has made them attractive candidates for development as therapeutics. The objective of this review article is to describe the current relevance, main mechanisms presented, and the uses of antimicrobial peptides as new therapies in the clinical area. The information used was mainly compiled from scientific articles based on a systematic review of scientific papers with data on human AMPs and their different applications, searching...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobial potential; Immune system; Therapeutic agents.
Ano: 2020 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2020000200294
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Arginine metabolism in uricotelic species - doi: 10.4025/actascianimsci.v32i4.10990 Animal Sciences
Fernandes, Jovanir Inês Müller; Universidade Federal do Paraná; Murakami, Alice Eiko; UEM.
Due to the lack of a complete urea cycle, uricotelic species, such as broilers, are not able to synthesize de novo arginine (Arg), thus depending exclusively on dietary Arg. High levels of dietary lysine (Lys) increase the demand for Arg because of the antagonistic relationship between these amino acids. The Arg-Lys antagonism promotes an expressive increase in the renal Arg activity and consequently induces the degradation of Arg and the decrease in the activity of glycine amidinotransferase, an enzyme that uses Arg in the synthesis of muscle creatin. Arg is considered an important modulator of immunological and physiological processes. The degradation of Arg produces ornithine, a precursor of polyamines that are key to cell division, DNA synthesis, and...
Palavras-chave: Carbamoyl phosphatase synthetase; Creatine; Immune system; Nitric oxide; Polyamines; Urea cycle carbamoyl phosphatase synthetase; Creatine; Immune system; Nitric oxide; Polyamines; Urea cycle.
Ano: 2010 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/10990
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Avaliação da arginina dietética sobre a resposta imunológica de frangos de corte imunizados contra a Doença de Gumboro - doi: 10.4025/actascianimsci.v33i2.9738 Animal Sciences
Fernandes, Jovanir Inês Müller; Universidade Federal do Paraná; Rosa, Daniela Dalla; UFPR - Palotina; Ribeiro, Mayra Vissotto; UFPR-Palotina; Lima, Edna Tereza de; UFPR - Palotina; Fernandes, Nelson Luis Mello; UFPR - Palotina.
O estudo foi realizado com o objetivo de avaliar o efeito da suplementação de Arginina (Arg) sobre a resposta imune humoral e o desenvolvimento dos órgãos linfoides de frangos de corte imunizados contra a Doença de Gumboro. Foram utilizados 640 pintos de corte, distribuídos aleatoriamente em um delineamento inteiramente casualizado com quatro tratamentos (1. Controle, 2. Imunização, 3. Imunização + suplementação de L-Arg e 4. Suplementação de L-Arg.) e oito repetições de 20 aves cada. As aves dos tratamentos 3 e 4 foram imunizadas no 16° dia, contra a Doença de Gumboro (cepa intermediária plus). Amostras de soro das aves com 14, 21, 28 e 35 dias de idade foram analisadas por ELISA para detecção de título de anticorpos contra a Doença de Gumboro e...
Tipo: Pesquisa de campo Palavras-chave: 5.04.03.01-0 Aminoácido; Doença infecciosa da Bursa de Fabrício; Sistema imune; Título de anticorpos; Bolsa cloacal Nutrição animal amino acid; Infectious bursal disease; Immune system; Antibody titers; Cloacal bursa.
Ano: 2011 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/9738
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Broiler adaptation to post-hatching period Ciência Rural
Maiorka,Alex; Dahlke,Fabiano; Morgulis,Maria Silvia Furquim de Azevedo.
In the latest years more attention has been given to mechanisms for bird adaptation at post-hatching period by management of environmental conditions and formulations of diets offered during this period when digestive, immune, and thermo-regulating systems suffer slight changes. In post-hatching period, digestive system is anatomically complete, but its functionality is still immature in relation to adult birds. The chick immunity depends on maternal antibodies transferred to egg just before laying. In addition, variations within thermal comfort zone might affect initial development of chick. For example, high temperatures may induce hyperthermia with dehydration, while low temperatures may lead to hypothermia responsible by pulmonary hypertension...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Broiler; Digestive system; Immune system; Thermo-regulatory system.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000200057
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Effect of fatty acids on leukocyte function BJMBR
Pompéia,C.; Lopes,L.R.; Miyasaka,C.K.; Procópio,J.; Sannomiya,P.; Curi,R..
Fatty acids have various effects on immune and inflammatory responses, acting as intracellular and intercellular mediators. Polyunsaturated fatty acids (PUFAs) of the omega-3 family have overall suppressive effects, inhibiting lymphocyte proliferation, antibody and cytokine production, adhesion molecule expression, natural killer cell activity and triggering cell death. The omega-6 PUFAs have both inhibitory and stimulatory effects. The most studied of these is arachidonic acid that can be oxidized to eicosanoids, such as prostaglandins, leukotrienes and thromboxanes, all of which are potent mediators of inflammation. Nevertheless, it has been found that many of the effects of PUFA on immune and inflammatory responses are not dependent on eicosanoid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fatty acids; Immune system; Inflammation; Dietary lipids; Leukocytes.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100001
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Effects of diazepam on Mycobacterium bovis-induced infection in hamsters BJMBR
Righi,D.A.; Pinheiro,S.R.; Guerra,J.L.; Palermo-Neto,J..
The in utero exposure of hamsters to low doses of diazepam results in impaired host defense against Mycobacterium bovis during adulthood. Delayed developmental immunotoxicity, however, represents a specific situation that might not be general. The present experiment was undertaken to investigate the effects of diazepam on hamster resistance to M. bovis using adult animals. The effects of diazepam treatment on serum cortisol levels were also studied. Adult hamsters (N = 10 for each group) were treated with diazepam (E1 = 1.0, E2 = 2.0 or E3 = 3.0 mg kg-1 day-1 subcutaneously) or with control solution (C) for 30 days. Seven days after the beginning of the treatment, the animals received identical inoculum concentrations of M. bovis. Hamsters treated with the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacterium bovis; Host resistance; Macrophages; Diazepam; Immune system.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900014
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Effects of Glycyrrhizic Acid on Productive and Immune Parameters of Broilers Rev. Bras. Ciênc. Avic.
Ocampo,CL; Gómez-Verduzco,G; Tapia-Perez,G; Gutierrez,OL; Sumano,LH.
ABSTRACT Considering that glycyrrhizic acid (GRA) has been shown to have in-vitro and in-vivo antiviral activity against a wide range of viruses as well as immunostimulating activity, a trial to evaluate its effects on the performance and the immune response against Newcastle disease of broiler chickens was carried out. The study was performed with one-day-old Ross x Ross broiler chickens. GRA was added to the drinking water throughout the 49-d production cycle at a dose of 0.03%. Sample size of the trial was established in a pilot assay. Results showed that broiler chickens treated with GRA presented better weight gain, final body weight, feed conversion ratio, and lower mortality rate than the non-treated controls. In addition, GRA-treated birds...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Broiler chickens; Growth promotion; Immune system; Glycyrrhizic acid.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2016000300435
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Effects of methionine and arginine dietary levels on the immunity of broiler chickens submitted to immunological stimuli Rev. Bras. Ciênc. Avic.
Rubin,LL; Canal,CW; Ribeiro,ALM; Kessler,A; Silva,I; Trevizan,L; Viola,T; Raber,M; Gonçalves,TA; Krás,R.
The present study aimed at assessing the effects of methionine and arginine on the immune response of broiler chickens submitted to immunological stimuli. Three methionine concentrations (0.31, 0.51, and 0.66% from 1 to 21 days of age; 0.29, 0.49, and 0.64% from 22 to 42 days of age) and 2 arginine concentrations (1.33 and 1.83%; 1.14 and 1.64% for the same life periods) were tested. Birds were divided into two groups for immunological stimuli (3x2x2 arrangement). Vaccines against Marek's disease, fowl pox, infectious bronchitis, Freund's Complete Adjuvant, Sheep red blood cells (SRBC), and avian tuberculin were administered to one group as immunological stimuli; the other group did not receive any stimulus. The experiment was carried out with 432...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amino acids; Birds; Immune system; Vaccines.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2007000400006
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Effects of natural aging and gender on pro-inflammatory markers BJMBR
Milan-Mattos,J.C.; Anibal,F.F.; Perseguini,N.M.; Minatel,V.; Rehder-Santos,P.; Castro,C.A.; Vasilceac,F.A.; Mattiello,S.M.; Faccioli,L.H.; Catai,A.M..
The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study was to analyze the relationship between pro-inflammatory markers and age in the natural aging process of healthy individuals. One hundred and ten subjects were divided into 5 groups according to age (22 subjects/group). Interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) were quantified using the ELISA method. High-sensitivity C-reactive protein (hsCRP) was analyzed by turbidimetry according to laboratory procedures. The main findings of this study...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural aging; Inflammaging; Immune system; HsCRP; IL-6.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000900601
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Evolution and conservation of immunological activity BJMBR
Vaz,N.M..
Paraphrasing what Gregory Bateson says on evolution, we might say that: "Immunology has long been badly taught. In particular, students - and even professional immunologists - acquire theories of immunological activity without any deep understanding of what problems these theories attempt to solve."
Tipo: Info:eu-repo/semantics/other Palavras-chave: Theory; Immune system; Evolution; Conservation; Bateson; Maturana.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200002
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Gap junctions in the cardiovascular and immune systems BJMBR
Rozental,R.; Campos-de-Carvalho,A.C.; Spray,D.C..
Gap junctions are clusters of intercellular channels directly connecting the cytoplasm of adjacent cells. These channels are formed by proteins named connexins and are present in all metazoan organisms where they serve diverse functions ranging from control of cell growth and differentiation to electric conduction in excitable tissues. In this overview we describe the presence of connexins in the cardiovascular and lympho-hematopoietic systems giving the reader a summary of the topics to be covered throughout this edition and a historical perspective of the discovery of gap junctions in the immune system.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gap junctions; Cardiovascular system; Immune system; Connexins.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400001
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Glycoconjugates and polysaccharides of fungal cell wall and activation of immune system BJM
Pinto,M.R.; Barreto-Bergter,E.; Taborda,C.P..
The fate of organochlorine 14C-dicofol in activated sludge process was investigated. Results showed that the major part of radioactivity remained adsorbed on biological sludge. Consequently, its final disposal deserves special attention. The small amounts of dicofol, biotransformed or not, which remained in the treated effluent could contaminate receiving bodies.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycoproteins; Polysaccharides; Glycosphingolipids; Immune system; Fungi.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200001
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Hematological and immunological development from birth to six months of age in Holstein calves Arq. Bras. Med. Vet. Zootec.
Baccili,C.C.; Oliveira,S.M.F.N. de; Costa,J.F.R; Massoco,C.O.; Pozzi,C.R.; Gomes,V..
ABSTRACT The hematological and immunological development of calves from birth to 6 months of age was performed by hemogram and cellular phenotype. Ten male Holstein calves were assessed in 13 moments: before colostrum intake (D0), every 2 days until the 10th day of life (D2 to D10), at the 15th day after birth (D15), and then monthly up to 6 months (D180). Calves presented hemoconcentration on day (D) 0 and showed a gradual decrease in hematimetric rates until D180. The inversion of the neutrophilic for lymphocytic profile was observed on D4. The percentage of CD3+ cells on D10 was higher than D30 up to D180. The number of CD4+ and CD8+ cells did not change between time points. The number of CD21+ lymphocytes was significantly higher at early time points...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bovine; Immune system; Leukogram; Immunophenotyping; Flow cytometry.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000601823
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Hematological responses of tambaqui Colossoma macropomum (Serrassalmidae) fed with diets supplemented with essential oil from Mentha piperita (Lamiaceae) and challenged with Aeromonas hydrophila. Repositório Alice
RIBEIRO, S. C.; CASTELO, A. S.; SILVA, B. M. P. da; CUNHA, A. da S.; PROIETTI JÚNIOR, A. A.; YOSHIOKA, E. T. O..
In fish farmings, diseases can be reduced by using immunostimulants. The aim of this study was to evaluate the immunostimulant potential of Mentha piperita in tambaqui fed with 0, 0.5, 1.0 and 1.5% of oil per kg of commercial fish feed. The fish were inoculated with Aeromonas hydrophila to challenge them. Hematological and biochemical parameters were determined after 30 days of feeding and seven days after the challenge. There was no mortality and M. piperita oil did not influence fish production parameters. However, blood hemoglobin concentration (Hb) increased in the fish fed with 0.5 and 1.5% of oil per kg of diet; albumin increased in those fed with 1.0%; cholesterol increased in all groups with oil; and triglycerides increased in those fed with 0.5%....
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Freshwater fish; Immune system; Natural product; Bacterial challenge; Biochemistry; Peixe de água doce.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1043236
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Hematological responses of tambaqui Colossoma macropomum (Serrassalmidae) fed with diets supplemented with essential oil from Mentha piperita (Lamiaceae) and challenged with Aeromonas hydrophila Acta Amazonica
RIBEIRO,Suzana Cardoso; CASTELO,Antonielson Silva; SILVA,Bruna Marjara Picanço da; CUNHA,Andreza da Silva; PROIETTI JÚNIOR,Aldo Aparecido; OBA-YOSHIOKA,Eliane Tie.
ABSTRACTIn fish farmings, diseases can be reduced by using immunostimulants. The aim of this study was to evaluate the immunostimulant potential of Mentha piperita in tambaqui fed with 0, 0.5, 1.0 and 1.5% of oil per kg of commercial fish feed. The fish were inoculated with Aeromonas hydrophila to challenge them. Hematological and biochemical parameters were determined after 30 days of feeding and seven days after the challenge. There was no mortality and M. piperita oil did not influence fish production parameters. However, blood hemoglobin concentration (Hb) increased in the fish fed with 0.5 and 1.5% of oil per kg of diet; albumin increased in those fed with 1.0%; cholesterol increased in all groups with oil; and triglycerides increased in those fed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immune system; Natural product; Bacterial challenge; Biochemistry.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000100099
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Hematology and serum biochemistry of broilers at the initial and growth stages submitted to different levels of digestible sulfur amino acids Ciência Rural
Carvalho,Genilson Bezerra de; Martins,Poliana Carneiro; Rezende,Pedro Moraes; Santos,Januária Silva; Oliveira,Evelyn de; Trentin,Thays de Campos; Martins,Danieli Brolo; Stringhini,José Henrique; Café,Marcos Barcellos.
ABSTRACT: The objective of this study was to evaluate the effect of digestible methionine and cystine (Met + Cys) levels on the hematological and serum biochemical parameters of broiler chickens during the initial and growth stages. For this, 1,800 male chicks of the Coob 500 strain were used, with 900 chicks in the initial phase (1 to 21 days old) and 900 chicks in the growth phase (22 to 42 days old), distributed in a completely randomized design of five treatments with six replicates of 30 birds. The treatments consisted of 0.545, 0.616, 0.711, 0.782, and 0.853%; and 0.514, 0.571, 0.647, 0.704, and 0.761% digestible Met + Cys for “1 to 21” and “22 to 42” days of breeding, respectively. Results showed that digestible Met + Cys levels in broiler feed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amino acid metabolism; Cysteine; Methionine; Immune system; Poultry.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000500652
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Immunological effects of donor lymphocyte infusion in patients with chronic myelogenous leukemia relapsing after bone marrow transplantation BJMBR
Castro,F.A.; Palma,P.V.B.; Morais,F.R.; Voltarelli,J.C..
Allogeneic bone marrow transplantation (alloBMT) is the only curative therapy for chronic myelogenous leukemia (CML). This success is explained by the delivery of high doses of antineoplastic agents followed by the rescue of marrow function and the induction of graft-versus-leukemia reaction mediated by allogeneic lymphocytes against host tumor cells. This reaction can also be induced by donor lymphocyte infusion (DLI) producing remission in most patients with CML who relapse after alloBMT. The immunological mechanisms involved in DLI therapy are poorly understood. We studied five CML patients in the chronic phase, who received DLI after relapsing from an HLA-identical BMT. Using flow cytometry we evaluated cellular activation and apoptosis, NK...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Chronic myelogenous leukemia; Donor lymphocyte infusion; Immune system; Bone marrow transplantation.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200006
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Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids BJMBR
Calder,P.C..
1. Fish oils are rich in the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. Linseed oil and green plant tissues are rich in the precursor fatty acid, <FONT FACE="Symbol">a</font>-linolenic acid (18:3n-3). Most vegetable oils are rich in the n-6 PUFA linoleic acid (18:2n-6), the precursor of arachidonic acid (20:4n-6). 2. Arachidonic acid-derived eicosanoids such as prostaglandin E2 are pro-inflammatory and regulate the functions of cells of the immune system. Consumption of fish oils leads to replacement of arachidonic acid in cell membranes by eicosapentaenoic acid. This changes the amount and alters the balance of eicosanoids produced. 3. Consumption of fish oils diminishes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lymphocyte; Macrophage; Immune system; Inflammation; Fish oil; Polyunsaturated fatty acid; Cytokine; Eicosanoid.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400002
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Influence of sulfur amino acid levels in diets of broiler chickens submitted to immune stress Rev. Bras. Ciênc. Avic.
Rubin,LL; Ribeiro,AML; Canal,CW; Silva,IC; Trevizan,L; Vogt,LK; Pereira,RA; Lacerda,L.
Several changes in amino acid levels occur during an infection. As a rule, glycine, taurine and serine levels diminish considerably, while cysteine levels increase. Such changes may be attributed to the intense consumption of sulfur amino acids (SAA- methionine+cysteine) during infectious challenge. Methionine plays an important role in humoral and cellular immune responses. It has been suggested that such effect is exerted by intracellular glutathione and cysteine levels. Four-hundred thirty-two day-old Ross male broiler chickens were fed (from 1 to 42 days of age) three SAA levels in the diet (0.72, 0.82, and 0.92% from 1 to 21 days of age; 0.65, 0.75, and 0.85% from 22 to 42 days of age) and submitted to two immunological stimulus series. Vaccines...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immune system; Immunological stimulus; Methionine; Performance; Poultry.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2007000100008
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Live yeasts in the gut: Natural occurrence, dietary introduction, and their effects on fish health and development ArchiMer
Gatesoupe, Joel.
This minireview summarizes the present state of knowledge concerning the importance of yeasts in fish gut. Yeasts have been commonly isolated in the gastrointestinal tract, and high population densities were sometimes noted in healthy fish, but the data were quite variable in terms of colony counts and taxonomical diversity. Rhodotorula sp. seemed relatively frequent in both marine and freshwater fish, and Debaryomyces hansenii has been found to be dominant in rainbow trout. Some other dominant strains have been described, such as Metschnikowia zobelii, Trichosporon cutaneum, and Candida tropicalis in marine fish, and Candida sp., Saccharomyces cerevisiae, and Leucosporidium sp. in rainbow trout. The natural proliferation of yeasts in fish mucus may be...
Tipo: Text Palavras-chave: Immune system; Growth promotion; Gut maturation; Gastrointestinal microbiota; Probiotics; Yeast.
Ano: 2007 URL: http://archimer.ifremer.fr/doc/2007/publication-2144.pdf
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