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ABSENCE OF SEASONAL EFFECT ON THE IMMUNOMODULATORY ACTION OF BRAZILIAN PROPOLIS ON NATURAL KILLER ACTIVITY J. Venom. Anim. Toxins
SFORCIN,J. M.; KANENO,R.; FUNARI,S. R. C..
Propolis, a beehive product widely used in folk medicine as an antiinflammatory agent, has been attracting researchers' attention to scientifically elucidate its biological properties and therapeutic activities. The aim of this paper was to study the possible effect of propolis on natural killer activity, since propolis immunomodulatory action has been suggested, especially on non-specific immunity. Propolis was produced by africanized honeybees (Apis mellifera L.), collected throughout a whole year, and pooled by season. Hydroalcoholic solutions of propolis were prepared with each pool and administered to rats by gavage over three days. Natural killer activity of non-adherent spleen cells was evaluated by the 51Cr-release cytotoxicity assay against Yac-1...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propolis; Season; Immunomodulation; Natural killer activity; Cytotoxic assay.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100003
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Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L. BABT
Monteiro,Jessica Raquel Borges; Ardisson,Juliana Santa; Athaydes,Brena Ramos; Gonçalves,Rita de Cássia Ribeiro; Rodrigues,Ricardo Pereira; Kuster,Ricardo Machado; Kitagawa,Rodrigo Rezende.
Abstract Helicobacter pylori is a bacterium that reaches half of the world population and it’s recognized as the main cause of chronic gastritis and peptic ulcer. In this study, we evaluated the anti-H. pylori, antioxidant and immunomodulatory activities of the methanolic (MeOH) extract of Eugenia uniflora leaves and chemical profile. Anti-H. pylori activity was evaluated by spectrophotometric broth microdilution technique by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), in addition to the evaluation of the effect on the urease enzyme. The antioxidant activity was evaluated by capturing O2 •-, HOCl e NO• radicals. The immunomodulatory effect was evaluated on the cytokines TNF-α, IL-6 and on nitric...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Eugenia uniflora; Helicobacter pylori; Antioxidant; Immunomodulation.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100424
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Comparison of different monoclonal antibodies against immunosuppressive proteins of Ascaris suum BJMBR
Oshiro,T.M.; Rafael,A.; Enobe,C.S.; Fernandes,I.; Macedo-Soares,M.F..
The extract of Ascaris suum suppresses the humoral and cellular immune responses to unrelated antigens in the mouse. In order to further characterize the suppressive components of A. suum, we produced specific monoclonal antibodies which can provide an important tool for the identification of these proteins. The A. suum immunosuppressive fractions isolated by gel filtration from an extract of adult worms were used to immunize BALB/c mice. Popliteal lymph node cells taken from the immunized animals were fused with SP2/O myeloma cells and the cloned hybrid cells obtained were screened to determine the specificity of secreted antibodies. Three monoclonal antibodies named MAIP-1, MAIP-2 and MAIP-3 were selected and were shown to react with different epitopes...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Ascaris suum; Immunosuppression; Immunomodulation; Monoclonal antibody.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200009
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Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipase A2 encoding-genes in rat brain tissue. Repositório Alice
GAMA, M. A. S. da; RAPOSO, N. R. B.; MURY, F. B.; LOPES, F. C. F.; DIAS-NETO, E.; TALIB, L. L.; GATTAZ, W. F..
2015
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Alzheimer disease; Brain tissue; Conjugated linoleic acid; Dairy fat; Immunomodulation; Phospholipase A2.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1037109
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Decrease in Dengue virus-2 infection and reduction of cytokine/chemokine production by Uncaria guianensis in human hepatocyte cell line Huh-7. Repositório Alice
MELLO, C. da S.; VALENTE, L. M. M.; WOLFF, T.; LIMA JUNIOR, R. S.; FIALHO, L. G.; MARINHO, C. F.; AZEREDO, E. L.; OLIVEIRA PINTO, L. M.; PEREIRA, R. de C. A.; SIANI, A. C.; KUBELKA, C. F..
bitstream/item/177377/1/ART18008.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Medicina tradicional; Imunomodulação; Antivirais; Kaempferitrin; Antivirals; Uncaria guianensis; Traditional medicine; Immunomodulation; Dengue.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1090388
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Effect of lipoarabinomannan from Mycobacterium avium subsp avium in Freund’s incomplete adjuvant on the immune response of cattle BJMBR
Colavecchia,S.B.; Jolly,A.; Fernández,B.; Fontanals,A.M.; Fernández,E.; Mundo,S.L..
The aim of the present study was to determine whether lipoarabinomannan (LAM), in combination with Freund’s incomplete adjuvant (FIA), was able to improve cell-mediated and antibody-mediated immune responses against ovalbumin (OVA) in cattle. Twenty-three calves were assigned to four treatment groups, which were subcutaneously immunized with either OVA plus FIA, OVA plus FIA and LAM from Mycobacterium avium subsp avium, FIA plus LAM, or FIA alone. Lymphoproliferation, IFN-γ production and cell subpopulations on peripheral blood mononuclear cells before and 15 days after treatment were evaluated. Delayed hypersensitivity was evaluated on day 57. Specific humoral immune response was measured by ELISA. Inoculation with LAM induced higher levels of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipoarabinomannan; Cattle; Immunomodulation; Mycobacterium avium subsp avium.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200008
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Effects of a Sarcocystis gigantea Extract (SGE) on the Replication of Human Immunodeficiency Virus (HIV) OAK
Drösigk, U.; Tietz, H. J.; Pözsch, F.; Scholz, D.; Hiepe, T. H..
Palavras-chave: Sarcocystis gigantea; Lectin; Immunomodulation; Human Immunodeficiency Virus; HIV.
Ano: 1995 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/235
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Evaluation of the proliferative activity of methanol extracts from six medicinal plants in murine spleen cells BJPS
Zandonai,Rodrigo Hermes; Coelho,Fabiana; Ferreira,Juliana; Mendes,Ana Karla Bittencourt; Biavatti,Maique Weber; Niero,Rivaldo; Cechinel Filho,Valdir; Bueno,Ednéia Casagranda.
A number of natural compounds have been used as immunomodulatory agents, enabling the function of the immune system to be modified by stimulating or suppressing it. There has been increasing interest in the study of therapeutic action of plant extracts regarding their immunomodulatory activity. The aim of this study was to identify and evaluate the action of extracts of the medicinal plants Calophyllum brasiliense, Ipomoea pes-caprae, Matayba elaeagnoides, Maytenus robusta, Rubus imperialis and Vernonia scorpioides on the development of spleen cells from mice, using the in vitro cellular proliferation assay. The cells, obtained by mechanical rupture of mice spleen (5x10(4) cells/mL), were incubated with methanol extracts (10, 50, 100 and 200 µg/mL) and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Natural products/immunomodulatories; Immunomodulation; Calophyllum brasiliense/pharmacognosy; Ipomoea pes-caprae/pharmacognosy; Matayba elaeagnoides/pharmacognosy; Maytenus robusta/pharmacognosy; Rubus imperialis/pharmacognosy; Vernonia scorpioides/pharmacognosy.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200020
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Extraction of β-glucan from Saccharomyces cerevisiae: Comparison of different extraction methods and in vivo assessment of immunomodulatory effect in mice Ciênc. Tecnol. Aliment.
PENGKUMSRI,Noppawat; SIVAMARUTHI,Bhagavathi Sundaram; SIRILUN,Sasithorn; PEERAJAN,Sartjin; KESIKA,Periyanaina; CHAIYASUT,Khontaros; CHAIYASUT,Chaiyavat.
Abstract Beta-glucan (BG) is a conserved cell wall components of bacteria, fungi, and yeast. BG is an immunomodulator and stimulates the host immune system. This study was performed to screen Saccharomyces cerevisiae strain with high BG, extraction of BG using different chemical extraction methods, composition analysis of BG, and evaluation of the immunomodulatory effect of high-quality BG using mice model. Ten yeast strains were screened for high BG content using total glucan extraction kit and were subjected to FT-IR analysis. The kit based extraction revealed that HII31 showed a high content of total glucan and BG. HII31 cells were subjected to four different acid/base extractions, which indicated that combination of a strong base (NaOH) and weak acid...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beta-glucan; Saccharomyces cerevisiae; Immunomodulation; FTIR; Cytokines.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612017000100124
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Floridoside extracted from the red alga Mastocarpus stellatus is a potent activator of the classical complement pathway ArchiMer
Courtois, Anthony; Simon-colin, Christelle; Boisset, Claire; Berthou, Christian; Deslandes, Eric; Guezennec, Jean; Bordron, Anne.
Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important...
Tipo: Text Palavras-chave: Complement system; Immunomodulation; Marine algae; Alpha galactosyl glycerol.
Ano: 2008 URL: http://archimer.ifremer.fr/doc/2008/publication-6248.pdf
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Galectin-1, an alternative signal for T cell death, is increased in activated macrophages BJMBR
Rabinovich,G.A.; Riera,C.M.; Sotomayor,C.E..
Galectin-1 belongs to an evolutionarily conserved family of animal ß-galactoside-binding proteins, which exert their functions by crosslinking the oligosaccharides of specific glycoconjugate ligands. During the past decade, attempts to identify the functional role of galectin-1 suggested participation in the regulation of the immune response. Only in the last few years has the molecular mechanism involved in these properties been clearly elucidated, revealing a critical role for galectin-1 as an alternative signal in the generation of T cell death. In the present study we will discuss the latest advances in galectin research in the context of the regulation of the immune response, not only at the central level but also at the periphery. Moreover, we will...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Galectin-1; Apoptosis; Immunomodulation; Macrophage.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500009
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Galectins: a key intersection between glycobiology and immunology BJMBR
Rabinovich,G.A.; Riera,C.M.; Landa,C.A.; Sotomayor,C.E..
Galectins are a family of evolutionarily conserved animal lectins, widely distributed from lower invertebrates to mammals. They share sequence and structure similarities in the carbohydrate recognition domain and specificity for polylactosamine-enriched glycoconjugates. In the last few years significant experimental data have been accumulated concerning their participation in different biological processes requiring carbohydrate recognition such as cell adhesion, cell growth regulation, inflammation, immunomodulation, apoptosis and metastasis. In the present review we will discuss some exciting questions and advances in galectin research, highlighting the significance of these proteins in immunological processes and their implications in biomedical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Galectins; Immunomodulation; Apoptosis; Adhesion; Embryogenesis; Metastasis.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400002
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Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes J. Venom. Anim. Toxins incl. Trop. Dis.
Casella-Martins,Andrea; Ayres,Lorena R; Burin,Sandra M; Morais,Fabiana R; Pereira,Juliana C; Faccioli,Lucia H; Sampaio,Suely V; Arantes,Eliane C; Castro,Fabiola A; Pereira-Crott,Luciana S.
Abstract Background Tityus serrulatus scorpion venom (TsV) contains toxins that act on K + and Na + channels and account for the venom’s toxic effects. TsV can activate murine peritoneal macrophages, but its effects on human lymphocytes have been poorly investigated. Considering that lymphocytes may play an important role in envenomation, we assessed whether TsV affects the expression of phenotypic (CD3, CD4, and CD8) and activation (CD69, CD25, and HLA-DR) markers, cell proliferation, and cytokine production in peripheral blood mononuclear cells. Methods Cytotoxicity of TsV was evaluated via the MTT assay. Cell proliferation, expression of phenotypic and activation markers, and release of cytokines were assessed using flow cytometry, after treatment...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immunomodulation; Immunophenotyping; T lymphocyte; Cell proliferation; Cytokine; Tityus serrulatus venom.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100350
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Immunomodulatory properties of Alternanthera tenella Colla aqueous extracts in mice BJMBR
Guerra,R.N.M.; Pereira,H.-A.W.; Silveira,L.M.S.; Olea,R.S.G..
Plants from the genus Alternanthera are thought to possess antimicrobial and antiviral properties. In Brazilian folk medicine, the aqueous extract of A. tenella Colla is used for its anti-inflammatory activity. The present study investigated the immunomodulatory property of A. tenella extract by evaluating the antibody production in male albino Swiss mice weighing 20-25 g (10 per group). The animals received standard laboratory diet and water ad libitum. The effect of A. tenella extract (5 and 50 mg/kg, ip) was evaluated in mice immunized with sheep red blood cells (SRBC 10%, ip) as T-dependent antigen, or in mice stimulated with mitogens (10 µg, Escherichia coli lipopolysaccharide, LPS, ip). The same doses (5 and 50 mg/kg, ip) of A. tenella extract were...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Antitumor activity; Antibody; Immunomodulation; Ehrlich ascites; Alternanthera.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900011
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In vitro activity of hypnophilin from Lentinus strigosus: a potential prototype for Chagas disease and leishmaniasis chemotherapy BJMBR
Souza-Fagundes,E.M.; Cota,B.B.; Rosa,L.H.; Romanha,A.J.; Corrêa-Oliveira,R.; Rosa,C.A.; Zani,C.L.; Teixeira-Carvalho,A.; Martins-Filho,O.A..
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity onTrypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin has a slightly greater inhibitory activity (~71%) on T. cruzi amastigote (AMA) growth in vitro as well as on in vitro phytohemagglutinin (PHA)-induced peripheral blood mononuclear (PBMC) proliferation (~70%) compared to panepoxydone (69% AMA inhibition and 91% PBMC inhibition). Hypnophilin and panepoxydone at 1.25 μg/mL had 67% inhibitory activity onLeishmania (Leishmania) amazonensis amastigote-like (AMA-like) growth in vitro. The panepoxydone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas disease; Leishmaniasis; Chemotherapy; Immunomodulation; Hypnophilin; Lentinus strigosus.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100007
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Mechanism of action of probiotics BABT
Hemaiswarya,S; Raja,R.; Ravikumar,R.; Carvalho,Isabel S..
The modern diet doesn't provide the required amount of beneficial bacteria. Maintenance of a proper microbial ecology in the host is the main criteria to be met for a healthy growth. Probiotics are one such alternative that are supplemented to the host where by and large species of Lactobacillus, Bifidobacterium and Saccharomyces are considered as main probiotics. The field of probiotics has made stupendous strides though there is no major break through in the identification of their mechanism of action. They exert their activity primarily by strengthening the intestinal barrier and immunomodulation. The main objective of the study was to provide a deep insight into the effect of probiotics against the diseases, their applications and proposed mechanism of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anti-allergic; Gastrointestinal problems; Immunomodulation; Infectious diseases; Probiotics.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100015
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Propionibacterium acnes-killed attenuates the inflammatory response and protects mice from sepsis by modulating inflammatory factors BJID
Silva,José Bruno Nunes Ferreira da; Oliveira,Samara Kelly Mendonça de; Campos,Ingrid Araújo; Carvalho-Júnior,Carlson Helder Reis de; Coutinho,Thiago da Cunha; Silva,Teresinha Gonçalves.
BACKGROUND: Sepsis is a systemic inflammation associated with infection caused by pathogenic micro-organisms with high mortality rates. OBJECTIVE: In this study, we investigated the protective effect of Propionibacterium acnes-killed against polymicrobial sepsis induced by cecal ligation and puncture. METHODS: The mice were treated by intramuscular route in 1, 3, 5, and 7 days before the cecal ligation and puncture induction. The control group animals received vehicle (saline solution 0.9%) and the animals of the treated group received the P. acnes-killed (0.4 mg/animal). After anesthesia, midline laparotomy was performed with exposure of cecum followed by ligature and one transverse perforation of the same, with a 18 G needle, for induction of lethal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propionibacterium acnes; Immunomodulation; Sepsis; Cytokines.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100004
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The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses BJMBR
Vilar,M.L.L.V.; Frutuoso,M.S.; Arruda,S.M.; Lima,D.M.; Bezerra,C.S.; Pompeu,M.M.L..
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: SLAM; SAP; IFN-γ; Immunoreceptor; Immunomodulation.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002
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