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| El-Beitune,P.; Duarte,G.; Morais,E.N. de; Campbell,O.; Spara-Gadelha,P.; Mauad-Filho,F.; Quintana,S.M.; Rodrigues,L.C.. |
| Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with a = 0.05 and ß = 20%,... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: HIV; Infant toxicity; Pregnancy; Umbilical arterial pH; Apgar scores. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700010 |
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| El Beitune,Patrícia; Duarte,Geraldo; Campbell,Oona; Quintana,Silvana Maria; Rodrigues,Laura C.. |
| This study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to mothers taking zidovudine + lamivudine + nelfinavir (TT group, n = 22) and infants born to normal women (control group, n = 12). Umbilical cord blood from the newborn infant was used to determine liver transaminases and amylase. Data were analyzed statistically by nonparametric tests, with the level of significance set at p<0.05. The median levels for TT group newborns were 33.3 U/L for oxaloacetic transaminase, 21.5 U/L for pyruvic transaminase, 1.9 mg/dL for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Combination antiretroviral therapy; Hypothesis generation; Infant toxicity; Umbilical cord blood. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300003 |
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