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Avian cytokines in health and disease Rev. Bras. Ciênc. Avic.
Wigley,P; Kaiser,P.
Cytokines are proteins secreted by cells that play an important role in the activation and regulation of other cells and tissues during inflammation and immune responses. Although well described in several mammalian species, the role of cytokines and other related proteins is poorly understood in avian species. Recent advances in avian genetics and immunology have begun to allow the exploration of cytokines in health and disease. Cytokines may be classified in a number of ways, but may be conveniently arranged into four broad groups on the basis of their function. Proinflammatory cytokines such as interleukin-6 and interleukin-1beta play a role in mediating inflammation during disease or injury. Th1 cytokines, including interleukin-12 and interferon-gamma,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Immunity; Infectious disease; Inflammation; Vaccination.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2003000100001
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Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis BJID
Uchoa,Breno Kristoffer Beleza; Albério,Carlos Augusto Abreu; Pinto,Ana Carla Godinho; Lucena,Stefania de Medeiros Araujo; Vieira,José Luiz Fernandes.
ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 µg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) µg/mL, 0.55 (0.5) µg/mL and 0.46 (0.4) µg/mL. There was a high variation of rifampicin levels...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Infectious disease; Tuberculosis; Rifampicin.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200130
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Distribuição espaço - temporal da malária no Piauí de 2002 a 2013. Repositório Alice
SANTOS, A. C. dos; VALLADARES, G. S.; HASSUM, I. C..
A malária é uma doença infecciosa, aguda, febril transmitida pela picada da fêmea de mosquito do gênero Anopheles. O estudo teve como objetivo realizar análise da distribuição espaço-temporal dos casos de malária no Piauí entre 2002 a 2013. Nesta pesquisa foi utilizada a taxa de incidência cumulativa para análise dos casos e o Sistema de Informação Geográfico (SIG) para mapeamento espacial. Os resultados obtidos por meio do cálculo da taxa de Incidência Cumulativa (IC) demonstraram que os municípios de Campo Largo do Piauí, Matias Olímpio, Luzilândia, Madeiro e Porto foram os que apresentaram maior IC de malária (>15,4/100.000 hab.). As pessoas mais acometidas foram as residentes na área rural, sendo pouquíssimos os casos ocorridos na zona urbana dos...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Malária; Doença infecciosa; Distribuição geográfica; Anopheles; Infectious disease; Geographic distribution.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1048416
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Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance BJID
Soares,Killarney Ataide; Urdapilleta,Ada Amália Ayala; Santos,Gilcilene Maria dos; Carneiro,Andréa Lisboa; Gomes,Ciro Martins; Roselino,Ana Maria; Sampaio,Raimunda Nonata Ribeiro.
Background: Several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmaniaparasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is similar to that in which they cause infections in hosts.Objective: We attempted to validate a Leishmania mexicanaELISA exo-Ag for ATL diagnosis in Midwestern Brazil.Methods: A total of 281 patients were included in the study. We analysed pre-treatment blood from 98 ATL patients; out of those, 85.7% and 14.3% had cutaneous and mucosal forms,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diagnostics; Disease control; Infectious disease; Leishmaniasis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300302
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Inquérito epidemiológico para detecção de anticopos contra o vírus da língua azul e Brucella ovis em rebanhos ovinos da Microrregião de Juazeiro - Bahia. Repositório Alice
SOUZA, T. S. de..
Resumo: Com o objetivo de analisar a ocorrência de anticorpos contra o vírus da língua azul e Brucella ovis em ovinos de propriedades localizadas na Microrregião de Juazeiro, Bahia, um inquérito foi conduzido em rebanhos ovinos de oito municípios que compõem esta microrregião (Juazeiro, Casa Nova, Remanso, Campo Alegre de Lourdes, Pilão Arcado, Sento Sé, Sobradinho e Curaçá). Algumas características de manejo foram pesquisadas através da aplicação de questionários epidemiológicos. Para verificar a frequência de ovinos soropositivos para língua azul, o teste de imunodifusão em gel de ágar (IDGA) foi utilizado para pesquisar 469 amostras de soro oriundas de 58 rebanhos. Os resultados demonstraram que 0,43% (2/469) das amostras analisadas apresentaram...
Tipo: Tese/dissertação (ALICE) Palavras-chave: Sorologia; IDGA; Ocorrência; Doença infeccionsa; Brasil; Bahia; Juazeiro; Ovino; Doença animal; Brucelose ovina; Orbivirus; Língua Azul; Epidemiologia; Sheep; Infectious disease; Bluetongue virus; Animal disease; Serology; Epidemiology; Disease occurrence; Brazil.
Ano: 2011 URL: http://www.alice.cnptia.embrapa.br/handle/doc/927480
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Malaria vaccine: roadblocks and possible solutions BJMBR
Soares,I.S.; Rodrigues,M.M..
Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Plasmodium; Vaccine; Immunity; Infectious disease.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300002
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Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria BJID
Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Ferreira,Michelle Valéria Dias; Rivera,Juan Gonzalo Bardarez; Gomes,Margarete do Socorro Mendonça.
Abstract Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria. Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41 years with uncomplicated falciparum malaria were enrolled in the study. Mefloquine was administered to patients in both age groups at a dose of 20 mg kg−1. The steady-state drug concentrations were measured by reversed-phase high performance liquid chromatography. Results All patients had an undetectable mefloquine concentration on day 0. In adults, the plasma mefloquine concentrations ranged from 770 to 2930 ng mL−1 and the erythrocyte concentrations...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Infectious disease; Parasitology; Mefloquine.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500482
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Recombinant viruses as vaccines against viral diseases BJMBR
Souza,A.P.D.; Haut,L.; Reyes-Sandoval,A.; Pinto,A.R..
Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst them, vectors based on recombinant viruses have shown great promise and play an important role in the development of new vaccines. Many viruses have been investigated for their ability to express proteins from foreign pathogens and induce specific immunological responses against these antigens in vivo. Generally, gene-based vaccines can stimulate potent humoral and cellular immune responses and viral vectors might be an effective strategy for both the delivery of antigen-encoding genes and the facilitation and enhancement of antigen presentation. In order to be utilized as a vaccine carrier, the ideal viral vector should be safe and enable efficient presentation of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vaccine; Immunity; Recombinant viruses; Viral vectors; Infectious disease.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400004
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Susceptible-Infective-Recovered Type Epidemiological Models in Wild Animal Management : A Literature Review OAK
KAWATA, Yukichika; 河田, 幸視.
The Susceptible-Infective-Recovered (SIR) model has been used in many scientific areas to describe the diffusion of infectious diseases. Many researches have been conducted in wild animal management using SIR models. This paper reviews these existing researches to overview applied species, infectious diseases, types of SIR models, and others. SIR モデルは,感染症の伝播を表すモデルとして広く 用いられている。野生動物に対して,これまでに相当の 数の研究が蓄積されている。しかしながら,適用対象と なる野生動物や感染症,SIR モデルの種類について,著 者が知る限り既存研究の整理はされていない。そこで本 稿は,SIR モデルの野生動物への適用をレビューした。 野生動物管理に用いられ始めたのは1980年代初頭で,そ の後しばらくは狂犬病のみが研究対象であったが,1990 年代には細菌,2000年代にはプリオンにも適用されてい る。研究の過半は2000年代におこなわれており,近年の 数理的手法を用いた研究の必要性を反映した結果と思わ れる。しかしながら,研究の大半はヨーロッパやアメリ カに偏っており,研究の半分は狂犬病が占めている。今後は,わが国も含めた研究対象国の拡大や,適用する感 染症を広めてゆくことが必要と考えられる。
Palavras-chave: SIR model; Wild animal management; Infectious disease; Pathogen; SIR モデル; 野生動物管理; 感染症; 病原体.
Ano: 2010 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2719
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The One Health Concept: 10 Years Old and a Long Road Ahead ArchiMer
Destoumieux-garzon, Delphine; Mavingui, Patrick; Boetsch, Gilles; Boissier, Jerome; Darriet, Frederic; Duboz, Priscilla; Fritsch, Clementine; Giraudoux, Patrick; Le Roux, Frederique; Morand, Serge; Paillard, Christine; Pontier, Dominique; Sueur, Cedric; Voituron, Yann.
Over the past decade, a significant increase in the circulation of infectious agents was observed. With the spread and emergence of epizootics, zoonoses, and epidemics, the risks of pandemics became more and more critical. Human and animal health has also been threatened by antimicrobial resistance, environmental pollution, and the development of multifactorial and chronic diseases. This highlighted the increasing globalization of health risks and the importance of the human–animal–ecosystem interface in the evolution and emergence of pathogens. A better knowledge of causes and consequences of certain human activities, lifestyles, and behaviors in ecosystems is crucial for a rigorous interpretation of disease dynamics and to drive public policies. As a...
Tipo: Text Palavras-chave: One health; EcoHealth; Infectious disease; Non-communicable disease; Multifactorial disease; Ecotoxicology; Interdisciplinary research; Public health.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00425/53676/54518.pdf
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