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An acid-sensing ion channel that detects ischemic pain BJMBR
Naves,L.A.; McCleskey,E.W..
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory neurons that innervate muscle. One such compound is lactic acid. Here, we show that ASIC3 (acid-sensing ion channel #3) has the appropriate expression pattern and physical properties to be the detector of this lactic acid. In rats, it is expressed only in sensory neurons and then only on a minority (~40%) of these. Nevertheless, it is expressed at extremely high levels on virtually all dorsal root ganglion sensory neurons that innervate the heart. It is extraordinarily sensitive to protons (Hill slope 4,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pain; Ischemia; Dorsal root ganglia; Acid-sensing ion channels; Lactic acidosis.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100001
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Effects of dystocia on blood gas parameters, acid-base balance and serum lactate concentration in heavy draft newborn foals OAK
Kimura, Yuki; Aoki, Takahiro; Chiba, Akiko; Nambo, Yasuo.
Dystocia is often lethal for neonatal foals; however, its clinicopathological features remain largely unknown. We investigated the effect of dystocia on the foal blood profile. Venous blood samples were collected from 35 foals (5 Percheron and 30 crossbreds between Percheron, Belgian, and Breton heavy draft horses) at 0 hr, 1 hr, 12 hr and 1 day after birth. Dystocia was defined as prolonged labor >30 min with strong fetal traction with or without fetal displacement. The dystocia group (n=13) showed lower mean values for pH (P<0.01), bicarbonate (P<0.01), total carbon dioxide (P<0.05), and base excess (P<0.01) and higher mean values for anion gap (P<0.05) and lactate (P<0.01) immediately after birth than the normal group (n=22)....
Palavras-chave: Dystocia; Heavy draft horse; Lactic acidosis; Neonatal foal; PH.
Ano: 2017 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4533
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The measurement of urine pH to predict the amount of buffer used in the treatment of acute rumen lactic acidosis in cattle Ciência Rural
Maruta,Celso Akio; Leal,Marta Lizandra do Rego; Mendes Netto,Daniel; Mori,Clara Satsuki; Antonelli,Alexandre Coutinho; Ortolani,Enrico Lippi.
The purpose of the present study was to establish a practical, fast, precise and low-cost procedure to estimate the degree of metabolic acidosis in cattle with acute rumen lactic acidosis for further treatment. The rumen acidosis was induced experimentally in 40 crossbreed rumen-cannulated 1.5-year-old steers. The induction caused the development of the most characteristic clinical signs of acute rumen lactic acidosis, severe rumen acidosis and a moderate metabolic acidosis, which was evidenced by low blood pH, and blood bicarbonate concentration and base excess (BE). A highly positive correlation (r=0.80) between urinary pH and BE concentration, and between urinary pH and blood pH (r=0.75) was observed. The BE concentration estimated by urinary pH was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lactic acidosis; Urine pH; Cattle; Base excess; Treatment.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000300019
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