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Registros recuperados: 12
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Antifibrotic effects of total or partial application of amniotic membrane in hepatic fibrosis Anais da ABC (AABC)
MAMEDE,KARINA M.; SANT’ANNA,LUCIANA B..
Abstract: Liver fibrosis is the final common pathway of chronic liver diseases, having cirrhosis as a possible progression, which has liver transplantation as the only effective treatment. Human amniotic membrane represents a potential strategy as a therapy for liver fibrosis, due to its anti-inflammatory, anti-fibrotic and immunomodulatory properties. The aim of this study was to evaluate amniotic membrane effects as a treatment for hepatic fibrosis induced in rats by bile duct ligation (BDL), verifying alterations between two different forms of amniotic membrane application, around all the lobes of the liver and around only one lobe of the liver. Two weeks after inducing fibrosis, an amniotic membrane fragment was applied to the surface of the liver,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amniotic membrane; Histopathology; Immunohistochemistry; Liver fibrosis; Myofibroblasts.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500702
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Anti-hepatitis C virus treatment may prevent the progression of liver fibrosis in non-responder human immunodeficiency virus/hepatitis C virus coinfected patients BJID
Sagnelli,Caterina; Uberti-Foppa,Caterina; Galli,Laura; Pasquale,Giuseppe; Coppola,Nicola; Albarello,Luca; Doglioni,Carlo; Lazzarin,Adriano; Sagnelli,Evangelista.
AIM:To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon+Ribavirine regimen.MATERIALS AND METHODS:We investigated 49 patients with two sequential liver biopsies: 18 were non-responders to Interferon+Ribavirine treatment (Group hepatitis C virus Rx) administered after the 1st liver biopsy who underwent a 2nd liver biopsy after a median period of 3.92 year and 31 were patients who remained untreated for hepatitis C virus disease (Group hepatitis C virus untreated) after the 1st liver biopsy because of refusal and underwent a 2nd liver biopsy after a median period of 5.05-years. Most patients in both groups were under highly active antiretroviral therapy....
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV/HCV coinfection; HIV infection; HIV/HCV coinfection liver histology; Liver fibrosis.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200164
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Antiproliferative and cytotoxic effects of purple pitanga (Eugenia uniflora L.) extract on activated hepatic stellate cells. Repositório Alice
DENARDIN, C. C.; PARISI, M. M.; MARTINS, L. A. M.; TERRA, S. R.; BOROJEVIC, R.; VIZZOTTO, M.; PERRY, M. L.; EMANUELLI, T.; GUMA, F. T. C. R..
2013
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Liver fibrosis; Eugenia uniflora; Cytotoxicity; Cell cycle arrest; Death cell.
Ano: 2013 URL: http://www.alice.cnptia.embrapa.br/handle/doc/977990
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Apoptosis and progression of hepatic fibrosis in hepatitis C patients BJID
Schinoni,Maria Isabel; Paraná,Raymundo; Cavalcante,Daniel.
Hepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Hepatitis C; Liver fibrosis.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009
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Assessment of indicators of vitamin A status in non-cirrhotic chronic hepatitis C patients BJMBR
Santana,R.C.; Machado,A.A.; Martinelli,A.L.C.; Jordão,A.A.; Ramalho,L.N.Z.; Vannucchi,H..
Subjects with chronic liver disease are susceptible to hypovitaminosis A due to several factors. Therefore, identifying patients with vitamin deficiency and a requirement for vitamin supplementation is important. Most studies assessing vitamin A in the context of hepatic disorders are conducted using cirrhotic patients. A cross-sectional study was conducted in 43 non-cirrhotic patients with chronic hepatitis C to evaluate markers of vitamin A status represented by serum retinol, liver retinol, and serum retinol-binding protein levels. We also performed the relative dose-response test, which provides an indirect estimate of hepatic vitamin A reserves. These vitamin A indicators were assessed according to the stage of liver fibrosis using the METAVIR score...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vitamin A; Hepatitis C; Retinol; Retinol binding protein; Liver fibrosis.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100702
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Association of MICA gene polymorphisms with liver fibrosis in schistosomiasis patients in the Dongting Lake region BJMBR
Gong,Zheng; Luo,Qi-Zhi; Lin,Lin; Su,Yu-Ping; Peng,Hai-Bo; Du,Kun; Yu,Ping; Wang,Shi-Ping.
Major histocompatibility complex class I chain-related A (MICA) is a highly polymorphic gene located within the MHC class I region of the human genome. Expressed as a cell surface glycoprotein, MICA modulates immune surveillance by binding to its cognate receptor on natural killer cells, NKG2D, and its genetic polymorphisms have been recently associated with susceptibility to some infectious diseases. We determined whether MICA polymorphisms were associated with the high rate of Schistosoma parasitic worm infection or severity of disease outcome in the Dongting Lake region of Hunan Province, China. Polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (SBT) were applied for high-resolution allele typing of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Schistosoma japonicum; MICA; NKG2D; Gene polymorphism; Liver fibrosis.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300007
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Autophagy induced by purple pitanga (Eugenia uniflora L.) extract triggered a cooperative effect on inducing the hepatic stellate cell death. Repositório Alice
DENARDIN, C. C.; MARTINS, L. A. M.; PARISI, M. M.; VIEIRA, M. Q.; TERRA, S. R.; BARBÉ-TUANA, F. M.; BOROJEVIC, R.; VIZZOTTO, M.; EMANUELLI, T.; GUMA, F. C. R..
2016
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Autophagy; Cell death; Eugenia uniflora L; Fruits; Hepatic stellate cells; Liver fibrosis; Autophagy; Cell death; Eugenia uniflora L; Fruits; Hepatic stellate cells; Liver fibrosis.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1061904
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Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection BJID
Costa,Luciano Bello; Ferraz,Maria Lucia Gomes; Perez,Renata M.; Ferreira,Adalgisa S.; Matos,Carla Adriana L.; Lanzoni,Valéria P.; Silva,Antônio Eduardo.
There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C virus; Liver fibrosis; Patients.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500002
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Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis BJID
Ávila,Renata Eliane de; Carmo,Ricardo Andrade; Farah,Kátia de Paula; Teixeira,Antônio Lúcio; Coimbra,Lucas Viana; Antunes,Carlos Maurício de Figueiredo; Lambertucci,José Roberto.
BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver fibrosis; Hyaluronic acid; End-stage renal disease; Haemodialysis; Hepatitis C.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004
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Long-term effects of human amniotic membrane in a rat model of biliary fibrosis BJMBR
Sant'Anna,L.B.; Brito,F.S.; Barja,P.R.; Nicodemo,M.C..
Liver fibrosis is the most common outcome of chronic liver diseases, and its progression to cirrhosis can only be effectively treated with liver transplantation. The amniotic membrane (AM) has been studied as an alternative therapy for fibrosis diseases mainly for its favorable properties, including anti-inflammatory, anti-scaring and immunomodulatory properties. It was recently demonstrated that the AM reduces the progression of biliary fibrosis to its advanced stage, cirrhosis, when applied on the liver for 6 weeks after fibrosis induction. Here, we investigated the effects of AM on rat fibrotic liver, during a prolonged period of time. Fibrosis was induced by bile duct ligation (BDL), and at the same time, a fragment of AM was applied around the liver....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amniotic membrane; Bile duct ligation; Liver fibrosis; Long-term; Quantitative image analysis; Rat.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700611
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[RETRACTED ARTICLE] Characteristics of liver fibrosis with different etiologies using a fully quantitative fibrosis assessment tool BJMBR
Wu,Q.; Zhao,X.; You,H..
This study aimed to test the diagnostic performance of a fully quantitative fibrosis assessment tool for liver fibrosis in patients with chronic hepatitis B (CHB), primary biliary cirrhosis (PBC) and non-alcoholic steatohepatitis (NASH). A total of 117 patients with liver fibrosis were included in this study, including 50 patients with CHB, 49 patients with PBC and 18 patients with NASH. All patients underwent liver biopsy (LB). Fibrosis stages were assessed by two experienced pathologists. Histopathological images of LB slices were processed by second harmonic generation (SHG)/two-photon excited fluorescence (TPEF) microscopy without staining, a system called qFibrosis (quantitative fibrosis) system. Altogether 101 quantitative features of the SHG/TPEF...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver fibrosis; Quantitative assessment; Etiology.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600703
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Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C BJID
Moura,Alexandre Sampaio; Carmo,Ricardo Andrade; Teixeira,Antonio Lucio; Rocha,Manoel Otávio da Costa.
Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Chemokines; Tumor necrosis factor receptor; Interferon-alpha; Liver fibrosis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013
Registros recuperados: 12
Primeira ... 1 ... Última
 

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