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Registros recuperados: 14
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5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus BJMBR
Gualda,L.B.; Martins,G.G.; Müller,B.; Guimarães,F.S.; Oliveira,R.M.W..
The dorsal raphe nucleus (DRN) is the origin of ascending serotonergic projections and is considered to be an important component of the brain circuit that mediates anxiety- and depression-related behaviors. A large fraction of DRN serotonin-positive neurons contain nitric oxide (NO). Disruption of NO-mediated neurotransmission in the DRN by NO synthase inhibitors produces anxiolytic- and antidepressant-like effects in rats and also induces nonspecific interference with locomotor activity. We investigated the involvement of the 5-HT1A autoreceptor in the locomotor effects induced by NO in the DRN of male Wistar rats (280-310 g, N = 9-10 per group). The NO donor 3-morpholinosylnomine hydrochloride (SIN-1, 150, and 300 nmol) and the NO scavenger...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Dorsal raphe nucleus; Nitric oxide; Serotonin; 5-HT1A receptor; Locomotor activity.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400010
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Behavioral alterations and Fos protein immunoreactivity in brain regions of bile duct-ligated cirrhotic rats Anais da ABC (AABC)
SUEUR-MALUF,LUCIANA LE; VIANA,MILENA B.; NAGAOKA,MÁRCIA R.; AMORIM,ANA LAURA B.; CARDOSO,AMANDA N.; RODRIGUES,BRUNA C.; MENDES,NATÁLIA F.; BITTENCOURT,JACKSON C.; CÉSPEDES,ISABEL C..
Hepatic encephalopathy (HE) encompasses a variety of neuropsychiatric symptoms, including anxiety and psychomotor dysfunction. Although HE is a frequent complication of liver cirrhosis, the neurobiological substrates responsible for its clinical manifestations are largely unclear. In the present study, male Wistar rats were bile duct-ligated (BDL), a procedure which induces liver cirrhosis, and on the 21st day after surgery tested in the elevated plus-maze (EPM) and in an open field for anxiety and locomotor activity measurements. Analysis of Fos protein immunoreactivity (Fos-ir) was used to better understand the neurobiological alterations present in BDL animals. Plasma levels of ammonia were quantified and histopathological analysis of the livers was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiety; Bile-duct ligation; Fos-immunoreactivity; Hepatic encephalopathy; Locomotor activity.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100331
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Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats BJMBR
Souza,M.F.; Couto-Pereira,N.S.; Freese,L.; Costa,P.A.; Caletti,G.; Bisognin,K.M.; Nin,M.S.; Gomez,R.; Barros,H.M.T..
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol (0.05 mg/mL), progesterone plus estradiol, or the oil vehicle. Sham-operated control females received oil. Control and acute subgroups received injections of saline, while the repeated group received cocaine (15 mg/kg, ip) for 8 days. After 10 days, the acute and repeated groups received a challenge dose of cocaine, after which locomotion and stereotypy were monitored. The estrous cycle phase was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cocaine; Locomotor activity; Female rats; Estradiol; Progesterone; Stereotypic activity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600505
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Cardiovascular responses to locomotor activity and feeding in unrestrained three-toed sloths, Bradypus variegatus BJMBR
Duarte,D.P.F.; Jaguaribe,A.M.; Pedrosa,M.A.C.; Clementino,A.C.C.R.; Barbosa,A.A.; Silva,A.F.V.; Gilmore,D.P.; Da Costa,C.P..
Heart rate (HR) and systolic (SBP), diastolic (DBP) and mean (MBP) blood pressure were recorded by biotelemetry in nine conscious unrestrained sloths for 1 min every 15 min over a 24-h period. The animals were allowed to freely move in an acoustically isolated and temperature-controlled (24 ± 1ºC) experimental room with light-dark cycle (12/12 h). Behavior was closely monitored through a unidirectional visor and classified as resting (sitting or suspended), feeding (chewing and swallowing embauba leaves, Cecropia adenops), or locomotor activity around the tree trunk or on the room floor. Locomotor activity caused statistically significant increases in SBP (+8%, from 121 ± 22 to 131 ± 18 mmHg), DBP (+7%, from 86 ± 17 to 92 ± 10 mmHg), MBP (+8%, from 97 ± 19...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Tree-toed sloth; Heart rate; Blood pressure; Locomotor activity; Feeding behavior.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000016
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Combined effects of diethylpropion and alcohol on locomotor activity of mice: participation of the dopaminergic and opioid systems BJMBR
Gevaerd,M.S.; Sultowski,E.T.; Takahashi,R.N..
The widespread consumption of anorectics and combined anorectic + alcohol misuse are problems in Brazil. In order to better understand the interactive effects of ethanol (EtOH) and diethylpropion (DEP) we examined the locomotion-activating effects of these drugs given alone or in combination in mice. We also determined whether this response was affected by dopamine (DA) or opioid receptor antagonists. A total of 160 male Swiss mice weighing approximately 30 g were divided into groups of 8 animals per group. The animals were treated daily for 7 consecutive days with combined EtOH + DEP (1.2 g/kg and 5.0 mg/kg, ip), EtOH (1.2 g/kg, ip), DEP (5.0 mg/kg, ip) or the control solution coadministered with the DA antagonist haloperidol (HAL, 0.075 mg/kg, ip), the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diethylpropion; Ethanol; Locomotor activity; Dopamine; Opioid; Mice.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200015
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Comparison between circadian motor activity in pony and horse RChHN
PICCIONE,GIUSEPPE; GIANNETTO,CLAUDIA; MARAFIOTI,SIMONA; CASELLA,STEFANIA; CAOLA,GIOVANNI.
In this study we investigated the influence of body mass on the daily rhythm of total motor activity in ponies and horses. Six clinically healthy Shetland pony breed with a body mass of 180 ± 30 kg and six healthy horses Sella Italiana breed with a body mass of 530 ± 20 kg were used. Animals were equipped with actigraphy-based data loggers, Actiwatch-Mini® to record total activity. The application of two-way ANOVA showed a highly significant effect of time of day and body mass on motor activity. Cosinor analysis identified the periodic parameters and their acrophases during the two days of monitoring. Mesor and amplitude were statistically higher in horses than in ponies and no statistically significant differences was found about acrophases and...
Tipo: Journal article Palavras-chave: Body mass; Daily rhythm; Equus caballus; Locomotor activity.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2011000200010
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Effects of simultaneous exposure to stress and nicotine on nicotine-induced locomotor activation in adolescent and adult rats BJMBR
Zago,A.; Leão,R.M.; Carneiro-de-Oliveira,P.E.; Marin,M.T.; Cruz,F.C.; Planeta,C.S..
Preclinical studies have shown that repeated stress experiences can result in an increase in the locomotor response to the subsequent administration of drugs of abuse, a phenomenon that has been termed behavioral cross-sensitization. Behavioral sensitization reflects neuroadaptive processes associated with drug addiction and drug-induced psychosis. Although cross-sensitization between stress- and drug-induced locomotor activity has been clearly demonstrated in adult rats, few studies have evaluated this phenomenon in adolescent rats. In the present study, we determined if the simultaneous exposure to stress and nicotine was capable of inducing behavioral sensitization to nicotine in adolescent and adult rats. To this end, adolescent (postnatal day (P)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cross-sensitization; Locomotor activity; Nicotine; Stress; Adolescence.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100006
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Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant ArchiMer
Vignet, Caroline; Joassard, Lucette; Lyphout, Laura; Guionnet, Tiphaine; Goubeau, Manon; Le Menach, Karyn; Brion, Francois; Kah, Olivier; Chung, Bon-chu; Budzinski, Helene; Begout, Marie-laure; Cousin, Xavier.
The release of polycyclic aromatic hydrocarbons (PAHs) into the environment has increased very substantially over the last decades. PAHs are hydrophobic molecules which can accumulate in high concentrations in sediments acting then as major secondary sources. Fish contamination can occur through contact or residence nearby sediments or though dietary exposure. In this study, we analyzed certain physiological traits in unexposed fish (F1) issued from parents (F0) exposed through diet to three PAH mixtures at similar and environmentally relevant concentrations but differing in their compositions. For each mixture, no morphological differences were observed between concentrations. An increase in locomotor activity was observed in larvae issued from fish...
Tipo: Text Palavras-chave: Danio rerio; Polycyclic aromatic hydrocarbon; Offspring; Transgenerational effect; Heavy oil; Light crude oil; Locomotor activity; Photomotor response; Anxiety-like behavior.
Ano: 2015 URL: https://archimer.ifremer.fr/doc/00259/37030/35688.pdf
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Impairment of locomotor activity induced by the novelN-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice BJMBR
Silva,G.A.P.; Kummerle,A.E.; Antunes,F.; Fraga,C.A.M.; Barreiro,E.J.; Zapata-Sudo,G.; Sudo,R.T..
The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease central nervous system activity was investigated in male Swiss mice. LASSBio-785 or LASSBio-786 (30 mg/kg, ip) reduced locomotor activity from 209 ± 26 (control) to 140 ± 18 (P < 0.05) or 146 ± 15 crossings/min (P < 0.05), respectively. LASSBio-785 (15 or 30 mg/kg, iv) also reduced locomotor activity from 200 ± 15 to 116 ± 29 (P < 0.05) or 60 ± 16 crossings/min (P < 0.01), respectively. Likewise, LASSBio-786 (15 or 30 mg/kg, iv) reduced locomotor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: N-acylhydrazone; Locomotor activity; Sedation; Hypnosis; Benzodiazepine receptor; Flumazenil.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300263
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Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects Anais da ABC (AABC)
NEVES,GILDA; BORSOI,MILENE; ANTONIO,CAMILA B.; PRANKE,MARIANA A.; BETTI,ANDRESA H.; RATES,STELA M.K..
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antidepressant-like effect; Immobility behavior; Locomotor activity; Memory negative symptoms.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401655
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Locomotor activity of Phalerisida maculata Kulzer (Coleoptera, Tenebrionidae) on Chilean sandy beaches RChHN
JARAMILLO,EDUARDO; AVELLANAL,MARIA H; GONZALEZ,MARCIA; KENNEDY,FERGUS.
The locomotor activity of the beetle Phalerisida maculata Kulzer (Coleoptera Tenebrionidae) was studied on the surface of the substrate in two sandy beaches of the Chilean coast: one in north central (ca. 29ºS) and the other in south central Chile (ca.39ºS). During the summer period of 1991 the circadian locomotor activity was studied in the southern beach, while during that of 1997 in both beaches. To analyze the activity, pitfall traps were used which were ordered along two transects extended between the upper beach and the resurgence zone. The traps were checked (i.e. collection of captured insects) every two hours for a total period of 26 hours. The results showed that the adults of P. maculata were mostly active during the night hours, whereas the...
Tipo: Journal article Palavras-chave: Sandy beaches; Insecta; Coleoptera; Locomotor activity.
Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2000000100008
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Routine post-weaning handling of rats prevents isolation rearing-induced deficit in prepulse inhibition BJMBR
Rosa,M.L.N.M.; Silva,R.C.B.; Moura-de-Carvalho,F.T.; Brandão,M.L.; Guimarães,F.S.; Del Bel,E.A..
Rats reared under isolation conditions from weaning present a number of behavioral changes compared to animals reared under social conditions (group housing). These changes include deficits in prepulse inhibition (PPI) of the startle reflex to a loud sound. PPI refers to the reduction of the magnitude of the startle reflex when a relatively weak stimulus (the prepulse) precedes by an appropriate time interval the intense startle-elicing stimulus (the pulse). PPI is useful for studying sensorimotor integration. The present study evaluated the effect of handling on the impairment of PPI induced by isolation-rearing. Male Wistar rats (N = 11-15/group) were housed in groups (5 per cage and handled three times a week) or isolated (housed individually) since...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Stress; Rat; Schizophrenia; Social isolation; Prepulse inhibition; Locomotor activity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100018
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Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze BJMBR
Takahashi,R.N.; Berton,O.; Mormède,P.; Chaouloff,F..
The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of anxiety. Herein, the effects of SB 206553 in a 5-min elevated plus-maze test of anxiety were compared to those of the reference anxiolytic, diazepam, in two rat strains respectively displaying high (Lewis rats) and low (spontaneously hypertensive rats, SHR) anxiety. Diazepam (0.37, 0.75, or 1.5 mg/kg; 30 min before testing) increased in a dose-dependent manner the behavioral measures in SHR, but not in Lewis rats. On the other hand, SB 206553 (1.25, 2.5, or 5 mg/kg; 30 min before testing) failed to alter...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiety; Diazepam; Elevated plus-maze; Lewis rats; Spontaneously hypertensive rats; Locomotor activity; M-chlorophenylpiperazine; SB 206553.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500017
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The use of actometry and electronic nose devices to assess the locomotor activity of two species of Coccinellidae (Coleoptera) Ciencia e Investigación Agraria
Heit,Guillermo; Messina,Valeria; Mareggiani,Graciela; Cohen,Rosa; Carrizo,Paola.
The effect of odor signals on the locomotor activity of Cycloneda sanguinea and Harmonia axyridis was evaluated using two different actometric devices. The purpose of the analysis was to differentiate between the responses elicited by direct contact with the substrates and the responses that occurred if the coccinellids were exposed only to volátiles and had no direct substrate contact. The odor profile of the environmental volátiles (semiochemicals) in the bioassays was analyzed using an electronic nose (Modular Sensor System Moses II). The treatments used included volatiles emitted by pepper leaves (healthy or infested with Myzus persicae), M. persicae molts and honeydew, and healthy leaves treated with an artificial inducer of the systemic acquired...
Tipo: Journal article Palavras-chave: Acibenzolar-S-methyl; Coccinellidae; Electronic nose; Locomotor activity; Semiochemicals.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202011000200012
Registros recuperados: 14
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