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Myostatin regulation of muscle development: Molecular basis, natural mutations, physiopathological aspects Inra
Joulia-Ekaza, D.; Cabello, G..
Since its identification in 1997, myostatin has been considered as a novel and uniquenegative regulator of muscle growth, as mstn-/- mice display a dramatic and widespreadincrease in skeletal muscle mass. Myostatin also appears to be involved in musclehomeostasis in adults as its expression is regulated during muscle atrophy. Moreover,deletion of the myostatin gene seems to affect adipose tissue mass in addition to skeletalmuscle mass. Natural myostatin gene mutations occur in cattle breeds such as Belgian Blue,exhibiting an obviously increased muscle mass, but also in humans, as has recently beendemonstrated. Here we review these natural mutations and their associated phenotypes aswell as the physiological influence of the alterations in myostatin...
Tipo: Journal Article Palavras-chave: MYOSTATINE; MYOBLASTE; DEVELOPPEMENT MUSCULAIRE; APOPTOSE MYOSTATIN; MECHANISM; MUTATION; PHYSIOPATHOLOGY; MUSCLE DEVELOPMENT; MYOBLAST; GENE MUTATION; MUSCLE PATHOLOGY; CELL THERAPY; CELL SIGNALING.
Ano: 2006 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200765cad115&uri=/notices/prodinra1/2008/01/
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The insect attractant 1-Octen-3-o1 is the natural ligand of bovine odorant-binding protein Inra
Ramoni, R.; Vincent, F.; Grolli, S.; Conti, V.; Malosse, C.; Boyer, F.D.; Nagnan-Le Meillour, P.; Spinelli, S.; Cambillau, C.; Tegoni, M..
Bovine odorant-binding protein (bOBP) is a dimeric lipocalin present in large amounts in the respiratory and olfactory nasal mucosa. The structure of bOBP refined at 2.0-Å resolution revealed an elongated volume of electron density inside each buried cavity, indicating the presence of one (or several) naturally occurring copurified ligand(s) (Tegoni et al. (1996)Nat. Struct. Biol. 3, 863–867; Bianchet et al.(1996) Nat. Struct. Biol. 3, 934–939). In the present work, by combining mass spectrometry, x-ray crystallography (1.8-Å resolution), and fluorescence, it has been unambiguously established that natural bOBP contains the racemic form of 1-octen-3-ol. This volatile substance is a typical component of bovine breath and in general of odorous body...
Tipo: Journal Article Palavras-chave: TECHNIQUE ANALYTIQUE; SPECTROMÉTRIE DE MASSE; CHROMATOGRAPHIE EN PHASE GAZEUSE; STRUCTURE TRIDIMENSIONNELLE; LIGAND FLUORESCENCE SPECTROSCOPY; URINARY PROTEINS; NASAL-MUCOSA; AFFINITIES; MECHANISM; LIPOCALIN; MOSQUITOS; RECEPTOR.
Ano: 2001 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0200012319094103&uri=/notices/prodinra1/2010/10/
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