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Angiotensin II induces NF-κB, JNK and p38 MAPK activation in monocytic cells and increases matrix metalloproteinase-9 expression in a PKC- andRho kinase-dependent manner BJMBR
Yaghooti,H.; Firoozrai,M.; Fallah,S.; Khorramizadeh,M.R..
Angiotensin II (ANG II), the main effector of the renin-angiotensin system, is implicated in endothelial permeability, recruitment and activation of the immune cells, and also vascular remodeling through induction of inflammatory genes. Matrix metalloproteinases (MMPs) are considered to be important inflammatory factors. Elucidation of ANG II signaling pathways and of possible cross-talks between their components is essential for the development of efficient inhibitory medications. The current study investigates the inflammatory signaling pathways activated by ANG II in cultures of human monocytic U-937 cells, and the effects of specific pharmacological inhibitors of signaling intermediates on MMP-9 gene (MMP-9) expression and activity. MMP-9 expression...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Signaling; MMP-9; Monocytic cell.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000300003
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Avaliação das metaloproteinases de matriz no sangue de reprodutores caprinos naturalmente infectados com Artrite Encefalite Caprina na Região Semiárida do Brasil. Repositório Alice
BEZERRA JUNIOR, R. Q.; ELOY, A. M. X.; PEREIRA, E. P.; FURTADO, J. R.; SOUZA, K. C. de; LIMA, A. R.; PINHEIRO, R. R.; ANDRIOLI, A.; TEIXEIRA, M. F. da S..
[Evaluation of Matrix Metalloproteinases in Blood from Buck Naturally Infected with Caprine Arthritis Encephalitis in Semiarid Region of Brazil]. Background: Studies have attempted to understand the importance of metalloproteinase (MMPs) in the pathogenesis of diseases caused by lentiviruses, being the human immunodeficiency virus (HIV) the most investigated. Despite advances in studies with MMPs in others diseases, research correlating the presence and activity of gelatinases in animals affected by caprine arthritis encephalitis virus (CAEV), a lentiviruses, are incipient and there is a need for research aiming to understand the dynamic of these enzymes in animals infected and its relation to pathological condition. The aim of this study was to evaluate...
Tipo: Artigo de periódico Palavras-chave: CAEV; CAE; Artrite Encefalite Caprina; Zymography; Metalloproteinase; MMP-2; MMP-9; Zimografia; Metaloproteinase; Proteases.; Doença animal; Protease; Caprino; Caprine arthritis encephalitis virus; Goats; Metalloproteins..
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032515
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Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells BJMBR
Ma,Lei; Chen,Yongjun; Han,Rui; Wang,Shuangyi.
Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo. SCC9 cells were exposed to BITC (5 and 25 μM) for 24 and 48 h. Cell growth, apoptosis, invasion, and migration were detected in vitro by MTT, FITC-conjugated annexin V/propidium iodide staining followed by flow cytometry, Matrigel-coated semi-permeable modified Boyden, and wound-healing assay. S100A4, PUMA, and MMP-9 expressions were detected to investigate its mechanisms. Xenotransplantation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oral squamous cell carcinoma; Benzyl isothiocyanate; Apoptosis; S100A4; MMP-9; PUMA.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400605
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Increased immunohistochemical expression of YKL-40 in the spleen of patients with portal hypertension BJMBR
Wang,Dong; Lu,Jian-Guo; Wang,Qing; Du,Xi-Lin; Dong,Rui; Wang,Peng; Zhao,Lei; Jiang,Xue; Yuan,Li-Juan.
YKL-40 has been identified as a growth factor in connective tissue cells and also a migration factor in vascular smooth muscle cells. To a large extent, the increase of serum YKL-40 is attributed to liver fibrosis and asthma. However, the relationship of the expression and clinical/prognostic significance of YKL-40 to the splenomegaly of patients with portal hypertension is unclear. In the present study, the expression of YKL-40 was studied by immunohistochemistry in 48 splenomegaly tissue samples from patients with portal hypertension and in 14 normal spleen specimens. All specimens were quickly stored at -80°C after resection. Primary antibodies YKL-40 (1:150 dilution, rabbit polyclonal IgG) and MMP-9 (1:200 dilution, rabbit monoclonal IgG) and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: YKL-40; MMP-9; Splenomegaly; Fibrosis; Portal hypertension; Immunohistochemistry.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300013
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