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| ZIMMERMAN,Robert H; PAULINO,Francisco Xavier; ARRUDA,Mercia de. |
| From January 19 to February 25, 1997 an entomological survey of the seringais and larger towns along the Acre and Purus rivers was made as part of the project “Revisitando a Amazônia de Carlos Chagas; da Borracha a Biodiversidad”. Eleven anopheline species and 1285 specimens were collected landing on human baits. The four most abundant species were Anopheles albitarsis s.l. (n=778), A. darlingi (n=359), A. rangeli (n=69) and A. oswaldoi (n=60). A total of 252 larvae were collected of which 10 anopheline species were identified. The most abundant species collected were A. albitarsis s.l. (n=88), A. deaneorum (n=45) and A. triannulatus (n=40). The low numbers of Anopheles collected and the absence of the principal malaria vector A. darlingi at the seringais... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anopheles; Malaria; Amazon. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59671999000100165 |
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| Laxminarayan, Ramanan. |
| In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies to replace this failing drug. Although there are strong theoretical arguments in favor of switching to more expensive artemisinin-based combination treatments (ACTs), the validity of these arguments in the face of financial constraints has not been previously analyzed. In this paper, we use a Bioeconomic model of malaria transmission and evolution of drug resistance to examine questions of optimal treatment strategy and coverage when drug resistance places an additional constraint on choices available to the... |
| Tipo: Working or Discussion Paper |
Palavras-chave: Malaria; Mathematical models; Drug resistance; Bioeconomics; Health Economics and Policy; I10; I19; C61. |
| Ano: 2003 |
URL: http://purl.umn.edu/10699 |
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| Lomar,André V.; Vidal,José E.; Lomar,Frederico P.; Barbas,Carmen Valente; Matos,Gustavo Janot de; Boulos,Marcos. |
| Severe pulmonary involvement in malaria has been frequently reported in cases of Plasmodium falciparum infection, but rarely in vivax malaria. Among the 11 previous cases of vivax-related severe respiratory involvement described in the literature, all except one developed it after the beginning of anti-malarial treatment; these appear to correspond to an exacerbation of the inflammatory response. We report the case of a 43-year-old Brazilian woman living in a malaria-endemic area, who presented acute respiratory distress syndrome (ARDS) caused by P. vivax before starting anti-malarial treatment. The diagnosis was made based on microscopic methods. A negative rapid immunochromatographic assay, based on the detection of Histidine Rich Protein-2 (HRP-2) of P.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Malaria; Plasmodium vivax; Acute respiratory distress syndrome; Acute respiratory failure; Brazil. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500011 |
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| Reyser, Thibaud; To, Tung H.; Egwu, Chinedu; Paloque, Lucie; Nguyen, Michel; Hamouy, Alexandre; Stigliani, Jean-luc; Bijani, Christian; Augereau, Jean-michel; Joly, Jean-patrick; Portela, Julien; Havot, Jeffrey; Marque, Sylvain R. A.; Boissier, Jérôme; Robert, Anne; Benoit-vical, Françoise; Audran, Gérard. |
| Malaria and schistosomiasis are major infectious causes of morbidity and mortality in the tropical and sub-tropical areas. Due to the widespread drug resistance of the parasites, the availability of new efficient and affordable drugs for these endemic pathologies is now a critical public health issue. In this study, we report the design, the synthesis and the preliminary biological evaluation of a series of alkoxyamine derivatives as potential drugs against Plasmodium and Schistosoma parasites. The compounds (RS/SR)-2F, (RR/SS)-2F, and 8F, having IC50 values in nanomolar range against drug-resistant P. falciparum strains, but also five other alkoxyamines, inducing the death of all adult worms of S. mansoni in only 1 h, can be considered as interesting... |
| Tipo: Text |
Palavras-chave: Alkoxyamine; Alkylation; Heme; Malaria; Radical chemistry; Schistosomiasis. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00648/76024/76920.pdf |
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| Fontes,Aparecida Maria; Kashima,Simone; Bonfim-Silva,Ricardo; Azevedo,Rochele; Abraham,Kuruvilla Joseph; Albuquerque,Sérgio Roberto Lopes; Bordin,José Orlando; Langhi Júnior,Dante Mário; Covas,Dimas Tadeu. |
| Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazilian Amazon population; CR1 haplotypes; Knops blood group polymorphism; Malaria. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002 |
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| KIENEN, J. L. P.. |
| Devido à frequente aquisição de resistência dos parasitos da malária aos fármacos atuais, é de imprescindível importância a descoberta de novas substâncias que possam dar origem a novos tratamentos para esta doença que acomete milhões de pessoas por ano. O estudo de plantas medicinais é uma alternativa promissora como fonte de substâncias antimaláricas e a Amazonia é uma fonte inestimável para tal. Este trabalho investigou a composição química e o potencial antimalárico (antiparasitário) da planta Amazônica Croton sacaquinha Croizat. |
| Tipo: Teses |
Palavras-chave: Linalol; Óleos essenciais; Malaria; Plasmodium falciparum. |
| Ano: 2022 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1149947 |
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| Taylor-Robinson, Andrew W.; Heal, Karen G.. |
| Malaria is the world's most important parasitic disease, imposing a massive health burden on people living in the tropics, often in the poorest countries. The vast majority of deaths in humans from malaria are caused by one species of the hemoprotozoan, Plasmodium falciparum., against which effective control measures are urgently needed. The global situation has deteriorated in recent times due to increased resistance of the anopheline mosquitoes that transmit P. falciparum to insecticides, and of the parasites themselves to drug therapy. An efficacious and cost-effective vaccine against this parasite is considered a public health priority. A vaccine that targets pre-erythrocytic parasites in the liver could potentially prevent clinical disease by blocking... |
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Palavras-chave: Malaria; Plasmodium falciparum; Liver stage; Vaccine; Cellular immunity. |
| Ano: 2001 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/133 |
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| Rodulfo,H; De Donato,M; Mora,R; González,L; Contreras,C.E. |
| Whole blood samples (N = 295) were obtained from different locations in Amazonas and Sucre States, in Venezuela. Malaria was diagnosed by microscopy, OptiMAL™ and polymerase chain reaction (PCR), with Plasmodium vivax, P. falciparum, and P. malariae being detected when possible. We identified 93 infections, 66 of which were caused by P. vivax, 26 by P. falciparum, and 1 was a mixed infection. No infection caused by P. malariae was detected. The sensitivity and specificity of each diagnostic method were high: 95.7 and 97.9% for microscopy, 87.0 and 97.9% for OptiMAL, and 98.0 and 100% for PCR, respectively. Most samples (72.2%) showed more than 5000 parasites/µL blood. The sensitivity of the diagnosis by microscopy and OptiMAL decreased with lower... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Malaria; Molecular diagnosis of malaria; Microscopic diagnosis of malaria; Polymerase chain reaction; OptiMAL. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400012 |
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| SOUZA, K. R. de; ALVES, B. G.; RAPOSO, D. de S.; SOUSA, T. F.; DANTAS, P. H. S.; FELIX, C. G. S.; KRAMER, Y. V.; SILVA, G. F. da; KOOLEN, H. H. F.. |
| O bioma Amazônico abriga alta diversidade vegetal e microbiana. Nesta encontram-se os fungos endofíticos, capazes de habitar o interior das plantas, colonizando seus tecidos sem lhes causar danos aparentes. Estes também são capazes de produzir metabólitos secundários de importância econômica. Portanto, objetivou-se através deste estudo, a criação de uma micoteca de fungos endofíticos associados a frutas regionais com atividade antimalárica. |
| Tipo: Parte de livro |
Palavras-chave: Fungos endofíticos; Malaria. |
| Ano: 2019 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1121388 |
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| SOUZA, K. R. de; ALVES, B. G.; GONÇALVES, K. D.; RAPOSO, D. de S.; SOUSA, T. F.; DANTAS, P. H. S.; FELIX, C. G. S.; KRAMER, Y. V.; SILVA, G. F. da; KOOLEN, H. H. F.. |
| Objetivou-se por meio deste estudo, a criação de uma micoteca de fungos endofíticos associados a frutas regionais e sua avaliação antimalárica. |
| Tipo: Separatas |
Palavras-chave: Fungos endofíticos; Frutas amazônicas; 7º CDMicro; Malaria; Plasmodium. |
| Ano: 2018 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1095771 |
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