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Maternal undernutrition and the offspring kidney: from fetal to adult life BJMBR
Mesquita,F.F.; Gontijo,J.A.R.; Boer,P.A..
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure to fetal glucocorticoid, alterations in the components of the renin-angiotensin system, apoptosis, and DNA methylation. A low-protein diet during gestation decreases the activity of placental 11ß-hydroxysteroid dehydrogenase, exposing the fetus to glucocorticoids and resetting the hypothalamic-pituitary-adrenal axis in the offspring. The abnormal function/expression of type 1 (AT1R) or type 2 (AT2R) AngII receptors during any period of life may be the consequence or cause of renal adaptation. AT1R is up-regulated, compared with control, on...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nephrogenesis; Blood pressure; Angiotensin receptors; Glucocorticoids; Maternal undernutrition.
Ano: 2010 URL:
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