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| Alexandre,Tatiana Rodrigues; Lima,Marta Lopes; Galuppo,Mariana Kolos; Mesquita,Juliana Tonini; Nascimento,Matilia Ana do; Santos,Augusto Leonardo dos; Sartorelli,Patricia; Pimenta,Daniel Carvalho; Tempone,Andre Gustavo. |
| Abstract Background Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate action. In this work, we evaluated the mushroom Pleurotus salmoneostramineus in the search for potential antiparasitic compounds. Methods Fruit bodies of the basidiomycete Pleurotus salmoneostramineus were triturated and submitted to organic solvent extraction. After liquid-liquid partition of the crude extract, three fractions were obtained and the bioguided fractionation study was conducted to isolate... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pleurotus salmoneostramineus; Ergosterol; Trypanosoma cruzi; Mechanism of action. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100313 |
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| Bali,J.; Thakur,R.. |
| Botulinum toxin is the most potent toxin known. It is readily absorbed from mucosal surfaces. If dispersed as an aerosol or mixed in the food or water it can lead to a large outbreak of botulism. The disease presents as a symmetric descending paralysis in an afebrile patient. Cranial nerve involvement with diplopia, dysarthria, dysphonia, dysphagia and respiratory paralysis is seen after a variable incubation period. The treatment is mainly supportive. The source of the toxin is Clostridium botulinum, an anaerobic gram-positive spore-forming organism. Some other species of Clostridium like C. butyricum and C. baratii also produce the toxin. The toxin is heat labile and can be inactivated by heating at 100°C for 10 minutes. The toxin acts at the peripheral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Botulinum toxin; Mechanism of action; Botulism; Therapeutics. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400003 |
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| Samanta,A.K.; Jayapal,Natasha; Senani,S.; Kolte,A.P.; Sridhar,Manpal. |
| In recent years, there has been a growing appreciation on the relevance of gastrointestinal microflora in both ruminants and non-ruminants owing to revelation of their role in several physiological functions including digestion, nutrient utilization, pathogen exclusion, gastrointestinal development, immunity system, gut gene expression and quality of animal products. The ban imposed on the use of antibiotics and hormones in feed has compelled animal researchers in finding an alternative which could overcome the issues of conventional feed additives. Though the concept of prebiotic was evolved keeping in mind the gastrointestinal flora of human beings, presently animal researchers are exploring the efficiency of prebiotic (inulin) for modulating the gut... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prebiotic; Inulin; Mechanism of action; Livestock. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100001 |
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| REIS,F.C.; VICTÓRIA FILHO,R.; ANDRADE,M.T.; BARROSO,A.A.M.. |
| ABSTRACT: Sugarcane is one of the main agricultural cultivations of Brazil, and one of the crops in which herbicides are most applied. In the 2017/2018 season, the estimated sugarcane production was 694.54 million tons, with an estimated increase of 0.9% in yield for this season. In order to evaluate the use of herbicides in this crop in the São Paulo State during a five-year period, a survey was carried out with sugarcane farmers. The use of herbicides applied alone and in a formulated mixture, according to their mechanism of action, were evaluated from 2010 to 2014. Photosystem II inhibitor herbicides were the most used in this period and the total amount of herbicides of almost all mechanism of action increased from 2010 to 2014, except for photosystem... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Marketing; Mechanism of action; Research; Pesticides; Saccharum officinarum. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100262 |
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