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	Provedor de dados 60 (2) Autor Andreazza,Itamar Francisco (1) Carvalho,Flávia Chiva (1) Déo,Simone Cristina (1) Gonzaga,Edeilson Vitor (1) Gremião,Maria Palmira Daflon (1) Lacerda,Gabriel José Silveira (1) Naves,Valéria de Moura Leite (1) Pedreiro,Liliane Neves (1) Pereira,Gislaine Ribeiro (1) Piantino,Beatriz Lemos (1) Possamai,João Carlos (1) Mais... Palavra-chave Mesalazine (2) Chemical cross-linking (1) Chitosan (1) Coated pellets/dissolution profile (1) Coated pellets/evaluation (1) Drugs/modified release (1) Emulsion method (1) Extrusion- Spheronisation/pellets obtention (1) Polyelectrolyte crosslinking (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Development of mesalazine pellets coated with methacrylic-derived polymer 60 Déo,Simone Cristina; Andreazza,Itamar Francisco; Possamai,João Carlos. Mesalazine (5-ASA) is the standard drug for the treatment of inflammatory bowel disease (IBD) due to its local effect on intestinal and colonic mucosa. The effective and safe treatment of this disease requires more efficient delivery of the active substance to its site of action. The focus of this study was the use of multiparticulate systems, a modified release form in which the drug is divided into several functional subunits of release in the form of granules or pellets. When these forms are administered, they are rapidly disintegrated, distributing their content throughout the gastrointestinal tract. The aim of this study was to develop and evaluate a multiparticulate system consisting of pellets coated with polymer for pH-dependent release, derived... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesalazine; Coated pellets/evaluation; Coated pellets/dissolution profile; Extrusion- Spheronisation/pellets obtention; Drugs/modified release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100013 Evaluation of polyelectrolyte and emulsion covalent crosslink of chitosan for producing mesalasine loaded submicron particles 60 Lacerda,Gabriel José Silveira; Piantino,Beatriz Lemos; Gonzaga,Edeilson Vitor; Naves,Valéria de Moura Leite; Pedreiro,Liliane Neves; Gremião,Maria Palmira Daflon; Pereira,Gislaine Ribeiro; Carvalho,Flávia Chiva. This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical crosslinking of chitosan with genipin and (3) the water-in-oil emulsion method associated with chemical crosslinking with genipin. Systems were characterized by dynamic light scattering, zeta potential (ζ), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and a drug release profile. Method (1) was efficiently produced unloaded nanoparticles (491 nm, PdI=0.26 and ζ = 23.2), but the conditions for chitosan and HP cross-linking enhanced the precipitation of 5ASA. Method (2) caused the degradation of the drug.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsion method; Polyelectrolyte crosslinking; Chemical cross-linking; Chitosan; Mesalazine. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100602 Registros recuperados: 2 Primeira ... 1 ... Última

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