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1H NMR and UPLC-HRMS-based metabolomic approach for evaluation of the grape maturity and maceration time of Touriga Nacional wines and their correlation with the chemical stability. Repositório Alice
ALVES FILHO, E. G.; SILVA, L. M. A. e; LIMA, T. O.; RIBEIRO, P. R. V.; VIDAL, C. S.; CARVALHO, E. S. S.; DRUZIAN, J. I.; BIASOTO, A. C. T.; CANUTO, K. M..
Tipo: Artigo de periódico Palavras-chave: Harvest season; Chemical stability; PLS-DA; Metabolômica; Temporada de colheita; Estabilidade química; Quimiometria; Composto Fenólico; Phenolic compounds; Metabolomics; Chemometrics.
Ano: 2022 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1141102
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Age effects on gene expression related to the bacterial chondronecrosis with osteomyelitis in broiler. Repositório Alice
CANTAO, M. E.; ZANELLA, R.; PEIXOTO, J. de O.; IBELLI, A. M. G.; PANDOLFI, J. R. C.; SETTLES, M.; LEDUR, M. C..
Tipo: Separatas Palavras-chave: Gene expression; Metabolomics; Proteomics..
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1037119
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Análise metabolômica da castanheira (Bertholletia excelsa) e relação da atividade dos metabólitos secundários majoritários com a medicina popular. Repositório Alice
ANDRADE, E. X.; RODRIGUES, C. S.; EVARISTO, G. P. C.; NOGUEIRA, F. C. S.; WADT, L. H. de O..
A pesquisa deste trabalho tem como objetivo identificar os principais metabólitos secundários presentes na castanheira utilizando a técnica de análise metabolômica pela alta sensibilidade.
Tipo: Parte de livro Palavras-chave: Produto florestal não madeireiro (PFNM); Castanha do brasil; Metabólitos secundários; Metabolômica; Embrapa Rondônia; Porto Velho (RO); Rondônia; Amazônia Ocidental; Western Amazon; Castanha do Para; Bertholletia Excelsa; Etnobôtanica; Campo Experimental; Nontimber forest products; Brazil nuts; Ethnobotany; Secondary metabolites; Metabolomics; Demonstration farms.
Ano: 2021 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1135792
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Changes in metabolic profiling of sugarcane leaves induced by endophytic diazotrophic bacteria and humic acids. Repositório Alice
AGUIAR, N. O.; OLIVARES, F. L.; NOVOTNY, E. H.; CANELLAS, L. P..
Plant growth-promoting bacteria (PGPB) and humic acids (HA) have been used as biostimulants in field conditions. The complete genomic and proteomic transcription of Herbaspirillum seropedicae and Gluconacetobacter diazotrophicus is available but interpreting and utilizing this information in the field to increase crop performance is challenging. The identification and characterization of metabolites that are induced by genomic changes may be used to improve plant responses to inoculation. The objective of this study was to describe changes in sugarcane metabolic profile that occur when HA and PGPB are used as biostimulants. Inoculum was applied to soil containing 45-day old sugarcane stalks. One week after inoculation, the methanolic extracts from leaves...
Tipo: Artigo de periódico Palavras-chave: Substância húmica; Bactéria fixadora de nitrogênio; Bioestimulante; Promoção do crescimento vegetal; Biofertilizante; Humic substances; Nitrogen-fixing bacteria; Metabolomics; Plant growth; Biofertilizers.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1100181
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Estudo metabolômico e atividade gastroprotetora de macela-da-terra (Egletes viscosa L.-Asteraceae). Repositório Alice
CARVALHO, K. R..
Tese (Doutorado em Química Orgânica) Pós-Graduação em Química, Universidade Federal do Ceará, Fortaleza, 2021. Orientador: Prof. Edilberto Rocha Silveira Coorientador: Dr. Kirley Marques Canuto
Tipo: Teses Palavras-chave: Egletes viscosa; Quimiotipos; Metabolômica; Macela-da-terra; Atividade gastroprotetora; Gastroprotective activity; Asteraceae; Chemotypes; Metabolomics.
Ano: 2021 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1130994
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Evaluation of sample extracting methods of FCSM by Lactobacillus acidophilus based on a UPLC-Q-TOF-MS global metabolomics analysis BJM
Wang,Yongqiang; Zhang,Wenju; Nie,Cunxi; Chen,Cheng; Zhang,Xiaoyang; Hu,Jianhe.
Abstract The study of metabolomics requires extracting as many metabolites as possible from a biological sample. This study aimed to determine the optimal method for the extraction of metabolites from solid-state fermented cottonseed meal (FCSM). The UPLC-Q-TOF-MS global metabolomics technology was used to detect the metabolites in FCSM, and the extraction quantity and extraction efficiency of seven different extraction methods, specifically the WA, 50MeOH, 50MeOHB, 50MeCNB, 80MeOHB, 80MeOH and AMF methods were evaluated. The results showed that the number of VIP metabolites extracted by AMF method are 196 and 184 in ESI+ and ESI- mode respectively, it is the largest number of all exacted methods; and the AMF methods also provided a higher extraction...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolomics; Extract; Fermentation; FCSM; Lactobacillus acidophilus; UPLC-Q-TOF-MS.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200392
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Exploring the chemodiversity of tropical microalgae for the discovery of natural antifouling compounds ArchiMer
Réveillon, Damien; Tunin-ley, Alina; Grondin, Isabelle; Othmani, Ahlem; Zubia, Mayalen; Bunet, Robert; Turquet, Jean; Culioli, Gérald; Briand, Jean-françois.
Marine microalgae and cyanobacteria have largely been studied for their biotechnological potential and proved their ability to produce a wide array of bioactive molecules. We investigated the antifouling potential of unexplored benthic tropical microalgae using anti-adhesion and toxicity bioassays against two major micro- and ma crobiofoulers, namely bacteria and barnacles. Fifty strains belonging to six phyla [Cyanobacteria, Miozoa (Dinoflagellata), Bacillariophyta, Cryptophyta, Rhodophyta and Haptophyta] were isolated from southwestern Islands of the Indian Ocean. They were chosen in order to represent as much as possible the huge biodiversity of such a rich tropical ecosystem. The associated chemodiversity was highlighted by both NMR- and LC-MS-based...
Tipo: Text Palavras-chave: Microalgae; Antifouling; Bioassay; Chemodiversity; Bioprospecting; Metabolomics.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00454/56608/58333.pdf
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First insight on interactions between bacteria and the marine diatom Haslea ostrearia : Algal growth and metabolomic fingerprinting ArchiMer
Lepinay, Alexandra; Turpin, Vincent; Mondeguer, Florence; Grandet-marchant, Quentin; Capiaux, Herve; Baron, Regis; Lebeau, Thierry.
A first insight on the interactions between bacteria isolated from monospecific cultures of the marine diatom Haslea ostrearia and this microalgae is described in this work. From 28 bacterial isolates, the maximal growth rate and the maximal cell concentration were on average 58% and 27% higher (max. 67% for isolate B22). Isolates B5, B10 (both Saccharospirillum sp.) and B22 (Rhodobacter sp.) were the most efficient. The geographical origin of H. ostrearia from which bacteria were isolated had no impact on the algal growth performances, and a given bacterial isolate led to the same algal growth irrespective of the geographical origin of H. ostrearia. To explain the results obtained, a comprehensive integrative strategy was conducted that analyzed the...
Tipo: Text Palavras-chave: Bacterial selection; Plant-growth-promoting bacteria; Phycosphere; Metabolomics.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00429/54036/55340.pdf
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GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. Repositório Alice
GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J..
Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic...
Tipo: Artigo de periódico Palavras-chave: Metabolômica; Residuo agroindustrial; Agroindustria; Co-produto; Spondias Mombin; Umbu; Cromatografia; Yellow mombins; Chromatography; Metabolomics; Spondias.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219
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GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. Repositório Alice
GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J..
Tipo: Artigo de periódico Palavras-chave: Metabolômica; Spondias Mombin; Umbu; Cromatografia; Yellow mombins; Chromatography; Metabolomics.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1118083
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High throughput mass spectrometry platform for prospecting high value chemicals from bioconversion of glycerin. Repositório Alice
AMAZONAS, D. R.; SOUTO, A. L.; VIEIRA, F. S.; CARNEIRO, A. A. J.; VIANNA, R. B.; MENDES, T. D.; LIMA, K. S.; RIBEIRO, J. A. A.; DAMASO, M. C. T.; RODRIGUES, C. M.; ABDELNUR, P. V..
Tipo: Separatas Palavras-chave: DIMS; Filamentous fungi; Metabolomics; Mass spectrometry; Biotechnology.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1113564
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How does extrusion chage the phenolic profileand impact protein digestibility in sorghum flours? Repositório Alice
D'ALMEIDA, C. T. S.; MAMERI, H.; MOREL, M. H.; CARVALHO, C. W. P. de; QUEIROZ, V. A. V.; CAMERON, L. C.; TAKEITI, C. Y.; FERREIRA, M. S. L..
In this work, the effect of thermoplastic extrusion on the phenolic compounds (PC)profile by UPLC-MSEand on the solubility/polymerization of kafirins by SE-HPLC was evaluated in extruded whole sorghum, with or withouttannins. Free (FPC) and bound (BPC)phenolic compoundswere extracted separately.The characteristics evaluated are antioxidant activity (by the methods DPPH and FRAP),total phenoliccontent(by the methodology involving the Reagent of Folin Ciocalteu), total proanthocyanidinscontent (TPAC) and total flavonoid content (TFC). FPC and BPC ranged from 41.1 to 434.3and 8.2to 283.7mg GAE/100g (db), respectively.DPPH and FRAP analysis showed a strong correlation with TPC (0.99and 0.95, p< 0.05, respectively). TPAC and TFC showthe degradation of...
Tipo: Anais e Proceedings de eventos Palavras-chave: Properties changes; Food technology; Sorghum bicolor subsp. bicolor; Kafirins; Tannins; Metabolomics.
Ano: 2020 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1125541
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Insights from a Multi-Omics Integration (MOI) Study in Oil Palm (Elaeis gineensis Jacq.) Response to Abiotic Stresses: Part One?Salinity. Repositório Alice
BITTENCOURT, C. B.; SILVA, T. L. C. da; RODRIGUES NETO, J. C.; VIEIRA, L. R.; LEAO, A. P.; RIBEIRO, J. A. de A.; ABDELNUR, P. V.; SOUSA, C. A. F. de; SOUZA JUNIOR, M. T..
Oil palm (Elaeis guineensis Jacq.) is the number one source of consumed vegetable oil nowadays. It is cultivated in areas of tropical rainforest, where it meets its natural condition of high rainfall throughout the year. The palm oil industry faces criticism due to a series of practices that was considered not environmentally sustainable, and it finds itself under pressure to adopt new and innovative procedures to reverse this negative public perception. Cultivating this oilseed crop outside the rainforest zone is only possible using artificial irrigation. Close to 30% of the world?s irrigated agricultural lands also face problems due to salinity stress. Consequently, the research community must consider drought and salinity together when studying to...
Tipo: Artigo de periódico Palavras-chave: African oil palm; Integratomics; Transcriptomics; Proteomics; Metabolomics; Abiotic stress.
Ano: 2022 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144868
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Marsdenia tenacissima extract alters crucial metabolites in cancer, determined by 1 H NMR based metabolomics approach BJPS
Roy,Debmalya; Chen,Cheng; Wang,Jun-song; Yuan,Shengtao; Sun,Li.
ABSTRACT Altered metabolites level in the biosystems, is the potential cause of cancer, the primary reason of alteration of metabolism is change in nutrient consumption and waste excretion, as a result genetic mutation leads to cancer initiation and progression. Aberration of specific metabolites such as fumarate, succinate, 2-hydroxyglutarate may alter cell signaling. We collected liver and kidney samples and prepared for 1H NMR analysis, then executed NMR spectroscopy. We used a set of domestic R scripts to perform an unsupervised principal component analysis (PCA) and a supervised orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA). It signifies class discrimination for getting a clear separation, whereas PCA scores...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Marsdenia tenacissima extract (MTE); MDA-MB-231; 1H NMR; Metabolomics.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200603
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Metabolic analysis of the effect of rheum on a taurocholate-induced acute pancreatitis rat model BJPS
Chen,Zhonghua; Shen,Li; Yang,Changyong; Jiang,Jinghui; Liu,Xing.
ABSTRACT The effects of rheum on serum parameters in a taurocholate-induced acute pancreatitis (AP) rat model were investigated using pathological and biochemical tests, and a proton nuclear magnetic resonance (1H NMR)-based metabonomic strategy. Healthy rats and rats with AP were either treated with rheum (7.5% at a dose of 1.5 g/kg) or left untreated. Serum samples were collected from the AP and rheum-treated groups at 6, 12, and 24 h after treatment. The effect of rheum on pathological changes in the pancreatic was investigated to validate the AP model. We obtained 1H NMR spectra and analyzed the results using the partial least squares discriminant method. The results of the pathological and metabolic analyses revealed an amelioration of multiple...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rheum/effects; Acute pancreatitis/analysis; Metabolomics; 1H NMR; Pathological changes; Rats.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200633
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Metabolic flux analysis for metabolome data validation of naturally xylose-fermenting yeasts. Repositório Alice
VERAS, H. C. T.; CAMPOS, C. G.; NASCIMENTO, I. F.; ABDELNUR, P. V.; ALMEIDA, J. R. M. de; PARACHIN, N. S..
Tipo: Artigo de periódico Palavras-chave: Xylose metabolism; Cofactor balance; Metabolome; Metabolomics.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1117553
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Metabolomic Profiles of Dinophysis acuminata and Dinophysis acuta Using Non-Targeted High-Resolution Mass Spectrometry: Effect of Nutritional Status and Prey ArchiMer
Garcia-portela, Maria; Reguera, Beatriz; Sibat, Manoella; Altenburger, Andreas; Rodriguez, Francisco; Hess, Philipp.
Photosynthetic species of the genus Dinophysis are obligate mixotrophs with temporary plastids (kleptoplastids) that are acquired from the ciliate Mesodinium rubrum, which feeds on cryptophytes of the Teleaulax-Plagioselmis-Geminigera clade. A metabolomic study of the three-species food chain Dinophysis-Mesodinium-Teleaulax was carried out using mass spectrometric analysis of extracts of batch-cultured cells of each level of that food chain. The main goal was to compare the metabolomic expression of Galician strains of Dinophysis acuminata and D. acuta that were subjected to different feeding regimes (well-fed and prey-limited) and feeding on two Mesodinium (Spanish and Danish) strains. Both Dinophysis species were able to grow while feeding on both...
Tipo: Text Palavras-chave: Dinophysis physiology; Lipophilic toxins; Non-targeted analysis; Metabolomics.
Ano: 2018 URL: http://archimer.ifremer.fr/doc/00439/55077/56508.pdf
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Metabolomics and agriculture: what can be done? Repositório Alice
PRADO, R. M. do; PORTO, C.; NUNES, E.; AGUIAR, C. L. de; PILAU, E. J..
Tipo: Separatas Palavras-chave: Agricultura; Espectrometria; Agriculture; Livestock; Mass spectrometry; Metabolomics.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1104824
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Metabolomics as a promising tool for early osteoarthritis diagnosis BJMBR
de Sousa,E.B.; dos Santos Junior,G.C.; Duarte,M.E.L.; Moura Neto,V.; Aguiar,D.P..
Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Metabolomics is an emerging field and has the potential to detect many metabolites in a single spectrum using high resolution nuclear magnetic resonance (NMR) techniques or mass spectrometry (MS). NMR is a reproducible and reliable non-destructive analytical method. On the other hand, MS has a lower detection limit and is more destructive, but it is more sensitive. NMR and MS are useful...
Tipo: Info:eu-repo/semantics/article Palavras-chave: NMR; Metabolomics; Osteoarthritis; Synovial Fluid.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100301
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Metabolomics based on UHPLC-QToF- and APGC-QToF-MS reveals metabolic pathways reprogramming in response to tidal cycles in the sub-littoral species Mimachlamys varia exposed to aerial emergence ArchiMer
Ory, Pascaline; Bonnet, Antoine; Mondeguer, Florence; Breitwieser, Marine; Dubillot, Emmanuel; Graber, Marianne.
Mimachlamys varia is a sub-littoral bivalve encountered from Norway to the Mediterranean Sea, which lives mostly byssally attached to rocks. During the low tide period, M. varia individuals, located highest on the shore, may experience short time of aerial exposure and face a low availability of oxygen. Here we report a comparative metabolomic profiling of gill samples of M. varia obtained by both LC-QToF and APGC-QToF mass spectrometry, to analyze metabolic changes occurring during emersion in comparison with immersion. Scallops were grown in aquaria with a simulated intertidal environment mimicking short-duration air exposure that they might experience during extreme tides: alternating 2 h emersion and 10 h immersion. Our results show a switch from...
Tipo: Text Palavras-chave: Anaerobic; APGC-QToF mass spectrometry; Hypoxia; Intertidal; LC-QToF mass spectrometry; Metabolomics; Mimachlamys varia; PLS-DA.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00466/57741/59936.pdf
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