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Dynamics of miR156 and miR172 involved in the flowering of Jatropha curcas L. Acta Botanica
Sánchez-Gutiérrez,Adriana; Ovando-Medina,Isidro; Adriano-Anaya,Lourdes; Vázquez-Ovando,Alfredo; Salvador-Figueroa,Miguel.
ABSTRACT Jatropha curcas is a plant that accumulates high-quality oil in its seeds, which is capable of being transformed into liquid biofuel. However, several aspects of its flowering are still unknown, which is a key step in the production of fruits, seeds, and oil. Flowering is a complex process that is regulated by various factors at the molecular level, including microRNAs (miRNAs). There is evidence suggesting that the miRNAs of the miR156 and miR172 families play a key role in the flowering transition of plants. For this reason, the dynamics of miR156 and miR172 were studied during a production cycle of J. curcas. Our results reveal that J. curcas has a mechanism for the expression of these miRNAs that differs from that reported for the vast...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Flowering; Jatropha curcas; MiR156; MiR172; MiRNAs.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062018000100099
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Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer Genet. Mol. Biol.
Arámbula-Meraz,Eliakym; Bergez-Hernández,Fernando; Leal-León,Emir; Romo-Martínez,Enrique; Picos-Cárdenas,Verónica; Luque-Ortega,Fred; Romero-Quintana,Jose; Alvarez-Arrazola,Marco; García-Magallanes,Noemí.
Abstract Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene expression; Biomarker; MiRNAs; Correlation; Prostate cancer.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112
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Expression profile of endothelin receptors (ETA and ETB) and microRNAs-155 and -199 in the corpus cavernosum of rats submitted to chronic alcoholism and diabetes mellitus BJMBR
Gonçalves,F.Z.; Lizarte Neto,F.S.; Novais,P.C.; Gattas,D.; Lourenço,L.G.; de Carvalho,C.A.M.; Tirapelli,D.P.C.; Molina,C.A.F.; Tirapelli,L.F.; Tucci Jr,S..
Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ETA and ETB receptors. Our goal was to evaluate the effects of alcohol and diabetes and their relationship to miRNA-155, miRNA-199 and endothelin receptors in the corpus cavernosum and blood of rats submitted to the experimental model of diabetes mellitus and chronic alcoholism. Forty-eight male Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D), and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study the protein expression of endothelin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alcoholism; Corpus cavernosum; MiRNAs; Endothelin receptors.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300615
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Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension BJMBR
Luna,R.C.P.; de Oliveira,Y.; Lisboa,J.V.C.; Chaves,T.R.; de Araújo,T.A.M.; de Sousa,E.E.; Miranda Neto,M.; Pirola,L.; Braga,V.A.; de Brito Alves,J.L..
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Epigenetic; Pulmonary arterial hypertension; DNA Methylation; Histone acetylation; MiRNAs.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
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MicroRNAs play critical roles during plant development and in response to abiotic stresses Genet. Mol. Biol.
Lima,Júlio César de; Loss-Morais,Guilherme; Margis,Rogerio.
MicroRNAs (miRNAs) have been identified as key molecules in regulatory networks. The fine-tuning role of miRNAs in addition to the regulatory role of transcription factors has shown that molecular events during development are tightly regulated. In addition, several miRNAs play crucial roles in the response to abiotic stress induced by drought, salinity, low temperatures, and metals such as aluminium. Interestingly, several miRNAs have overlapping roles with regard to development, stress responses, and nutrient homeostasis. Moreover, in response to the same abiotic stresses, different expression patterns for some conserved miRNA families among different plant species revealed different metabolic adjustments. The use of deep sequencing technologies for the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MiRNAs; Development; Abiotic stress; Nutrients; Deep sequencing.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600023
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Multi-omics approach reveals miR-SNPs affecting muscle fatty acids profile in Nelore cattle. Repositório Alice
CARDOSO, T. F.; COUTINHO, L. L.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; POLETI, M. D.; CESAR, A. S. M.; SILVEIRA, J. C. DA; CHIARATTI, M. R.; ZERLOTINI NETO, A.; MOURÃO, G. B.; REGITANO, L. C. de A..
MicroRNAs (miRNAs) are key regulators of gene expression, potentially affecting several biological processes, whose function can be altered by sequence variation. Hence, the integration of single nucleotide polymorphisms (SNP) and miRNAs can explain individual differences in economic traits. To provide new insights into the effects of SNPs on miRNAs and their related target genes, we carried out a multi-omic analysis to identify SNPs in miRNA mature sequences (miR-SNPs) associated with fatty acid (FA) composition in the Nelore cattle. As a result, we identified 3 miR-SNPs in different miRNAs (bta-miR-2419-3p, bta-miR-193a-2, and bta-miR-1291) significantly associated with FA traits (p-value < 0.02, Bonferroni corrected). Among these, the...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Análise multiômica; Expressão gênica; Polimorfismo de nucleotídeo único; Association analysis; MiRNAs; Bos Indicus; Beef quality; Polymorphism; Gene expression; Single nucleotide polymorphism.
Ano: 2021 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1131655
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PAK6: a potential anti-cancer target BJPS
Gong,Chan-Chan; Li,Tong-Tong; Pei,Dong-Sheng.
p21-activated kinase 6 (PAK6) is a member of the PAK family of serine/threonine kinases that are known effectors of Rho GTPases Cdc42 and Rac. PAKs regulate a large number of complex cellular mechanisms, including cell motility, morphology, and tumor development. PAK6, initially cloned as an interacting partner of the androgen receptor (AR), is associated with an array of cellular processes implicated in tumor progression. However, the full biological implications of PAK6 activity during cancer remain poorly understood. In this review, we assess our current understanding of the physiological roles of classical PAK6 functionality in mammals, in addition to its emerging role in tumorigenesis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: PAK6; Androgen Receptor (AR); Cancer therapy; MiRNAs.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100700
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Solexa Profiling Identifies Differentially Expressed MiRNAs Between Sexually Immature and Mature Equine Testis BABT
He,Liangjun; Wang,Shiwei; Deng,Haifeng; Dong,Hong; Chen,Jingbo.
ABSTRACT MicroRNAs (miRNAs) are a class of short non-coding RNAs identified as potent regulators of gene expression. Previous studies have suggested that miRNAs are involved in mammalian spermatogenesis. Stallion fertility is an important trait for the horse breeding industry, but stallion fertility traits are largely ignored in the industry. In this study, we generated expression profiles of miRNAs in foal (immature) and stallion (mature) testes using Solexa sequencing. We identified 438 known and homologous equine miRNAs and 199 novel miRNAs which were distributed among all the chromosomes. The two developmental stages showed significant differences in miRNA expression patterns. Our result expands the horse miRNA database and provided additional...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Horse; MiRNAs; Solexa; Testis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100307
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