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An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle. Repositório Alice
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; TIZIOTO, P. C.; CESAR, A. S. M.; OLIVEIRA, G. B. de; DINIZ, W, J. da S.; LIMA, A. O. de; REECY, J. M.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REGITANO, L. C. de A..
Residual Feed Intake (RFI) is an economically relevant trait in beef cattle. Among the molecular regulatory mechanisms, microRNAs (miRNAs) are an important dimension in post-transcriptional regulation and have been associated with different biological pathways. Here, we performed differential miRNAs expression and weighted gene co-expression network analyses (WGCNA) to better understand the complex interactions between miRNAs and mRNAs expressed in bovine skeletal muscle and liver. MiRNA and mRNA expression data were obtained from Nelore steers that were genetically divergent for RFI (N = 10 [low RFI or feed efficient]; N = 10 [high RFI or feed inefficient]). Differentially expressed and hub miRNAs such as bta-miR-486, bta-miR-7, bta-miR15a, bta-miR-21,...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: MicroRNAs; Residual Feed Intake; Gado Nelore; Beef cattle; Nellore; Skeletal muscle.
Ano: 2018 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1102149
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Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods BJMBR
Wang,Liming; Zhu,L.; Luan,R.; Wang,L.; Fu,J.; Wang,X.; Sui,L..
Dilated cardiomyopathy (DCM) is characterized by ventricular dilatation, and it is a common cause of heart failure and cardiac transplantation. This study aimed to explore potential DCM-related genes and their underlying regulatory mechanism using methods of bioinformatics. The gene expression profiles of GSE3586 were downloaded from Gene Expression Omnibus database, including 15 normal samples and 13 DCM samples. The differentially expressed genes (DEGs) were identified between normal and DCM samples using Limma package in R language. Pathway enrichment analysis of DEGs was then performed. Meanwhile, the potential transcription factors (TFs) and microRNAs (miRNAs) of these DEGs were predicted based on their binding sequences. In addition, DEGs were mapped...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dilated cardiomyopathy; Differentially expressed genes; Pathway enrichment analysis; Transcription factors; MicroRNAs; Small molecules.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000706
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Circulating levels of inflammation-associated miR-155 and endothelial-enriched miR-126 in patients with end-stage renal disease BJMBR
Wang,Honglei; Peng,Wujian; Shen,Xuemei; Huang,Yunhui; Ouyang,Xin; Dai,Yong.
Circulating microRNAs (miRNAs) may represent a potential noninvasive molecular biomarker for various pathological conditions. Moreover, the detection of circulating miRNAs can provide important novel disease-related information. In particular, inflammation-associated miR-155 and endothelial-enriched miR-126 are reported to be associated with vascular homeostasis. Vascular damage is a common event described in end-stage renal disease (ESRD). We hypothesized that miR-155 and miR-126 may be detectable in the circulation and serve as potential biomarkers for risk stratification. In this study, we assessed miR-155 and miR-126 in the plasma of 30 ESRD patients and 20 healthy controls using real-time quantification RT-PCR. The circulating levels of miR-155 and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; End-stage renal disease; Hemodialysis; MiR-126; MiR-155.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200029
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Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants BJMBR
Fernandes,T.; Soci,U.P.R.; Oliveira,E.M..
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Cardiac hypertrophy; Renin-angiotensin system; AT1 receptor; Akt; MicroRNAs.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900003
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Identification of novel soybean microRNAs involved in abiotic and biotic stresses. Repositório Alice
KULCHESKI, F. R.; OLIVEIRA, L. F. V.; MOLINA, L. G.; ALMERÃO, M.; RODRIGUES, F. A.; MARCOLINO, J.; BARBOSA, J. F.; STOLF-MOREIRA, R.; NEPOMUCENO, A. L.; MARCELINO, F. C.; ABDELNOOR, R. V.; NASCIMENTO, L. C.; CARAZZOLLE, M. F.; PEREIRA, G. A. G.; MARGIS, R..
2011
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: MicroRNAs.
Ano: 2011 URL: http://www.alice.cnptia.embrapa.br/handle/doc/913711
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Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods BJMBR
Jiang,Tao; Si,Liangyi.
Aortic dissection is characterized by the redirection of blood flow, which flows through an intimal tear into the aortic media. The purpose of this study was to find potential acute type A aortic dissection (AAAD)-related genes and molecular mechanisms by bioinformatics. The gene expression profiles of GSE52093 were obtained from Gene Expression Omnibus (GEO) database, including 7 AAAD samples and 5 normal samples. The differentially expressed genes (DEGs) were detected between AAAD and normal samples. The functional annotation and pathway enrichment analysis were conducted through the Database for Annotation, Visualization and Integration Discovery (DAVID). A protein-protein interaction network was established by the Search Tool for the Retrieval of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aortic dissection; Differentially expressed genes; Functional enrichment analysis; Protein-protein interaction network; MicroRNAs; Small molecules.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100610
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In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis Genet. Mol. Biol.
Curcio,Juliana S. de; Batista,Mariana P.; Paccez,Juliano D.; Novaes,Evandro; Soares,Célia Maria de Almeida.
Abstract Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. These fungi present a plasticity to adapt and survive in different conditions, and the presence of microRNAs-like molecules could be part of the mechanisms that provide such plasticity. MicroRNAs produced by the host influence the progression of this mycosis in the lungs besides regulating targets involved in apoptosis in macrophage, activation of T and B cells and the production of cytokines. Therefore, this work analyzed the presence of regions in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fungi; Mycoses; Dicer; Argonaute; MicroRNAs.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100095
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MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy BJMBR
Kaneto,C.M.; Nascimento,J.S.; Moreira,M.C.R.; Ludovico,N.D.; Santana,A.P.; Silva,R.A.A.; Silva-Jardim,I.; Santos,J.L.; Sousa,S.M.B.; Lima,P.S.P..
Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. However, a few studies have investigated the potential of circulating miRNAs as biomarkers for left ventricular hypertrophy (LVH). In this study, we aimed to characterize the miRNA profiles that could distinguish hypertensive patients with LHV, hypertensive patients without LVH and control subjects, and identify potential miRNAs as biomarkers of LVH. LVH was defined by left ventricular mass indexed to body surface area >125 g/m2 in men and >110 g/m2 in women and patients were classified as hypertensive when presenting a systolic blood pressure of 140 mmHg or more, or a diastolic blood pressure of 90 mmHg or more. We employed miRNA PCR...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular disease; Hypertension; Left ventricular hypertrophy; MicroRNAs.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200605
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Quantitative expression of microRNAs in Brassica oleracea infected with Xanthomonas campestris pv. campestris. Repositório Alice
SANTOS, L. S.; MAXIMIANO, M. R.; MEGIAS, E.; PAPPAS, M. de C. R.; RIBEIRO, S. da G.; REIS, A. M. dos.
bitstream/item/198505/1/Santos2019-Article-QuantitativeExpressionOfMicroR.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Black rot disease; MicroRNAs; RT-qPCR; Northern blot; Biomarkers.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1109828
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Small RNA sequencing reveals microRNAs related to neuropathic pain in rats BJMBR
Dai,Dawei; Wang,Junyu; Jiang,Ying; Yuan,Lei; Lu,Youming; Zhang,Aijun; Zou,Dongdong; Chen,Xin.
The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 dorsal root ganglion. Real-time PCR was performed to validate the differently expressed miRNAs. Functional verification was performed by intrathecally injecting the animals with miRNA agomir. A total of 72 differentially expressed miRNAs were identified in the SNI rats, including 33 upregulated and 39 downregulated miRNAs. The results of qPCR further verified the expression levels of rno-miR-6215...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; Neuropathic pain; Spared nerve injury; Dorsal root ganglion.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000602
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The miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation of mouse embryonic cardiomyocytes BJMBR
Xiang,Rui; Lei,Han; Chen,Mianzhi; Li,Qinwei; Sun,Huan; Ai,Jianzhong; Chen,Tielin; Wang,Honglian; Fang,Yin; Zhou,Qin.
MicroRNAs (miRNAs) have gradually been recognized as regulators of embryonic development; however, relatively few miRNAs have been identified that regulate cardiac development. A series of recent papers have established an essential role for the miRNA-17-92 (miR-17-92) cluster of miRNAs in the development of the heart. Previous research has shown that the Friend of Gata-2 (FOG-2) is critical for cardiac development. To investigate the possibility that the miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation in mouse embryonic cardiomyocytes we initially used bioinformatics to analyze 3’ untranslated regions (3’UTR) of FOG-2 to predict the potential of miR-17-92 to target it. We used luciferase assays to demonstrate that miR-17-5p and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; MiR-17-92; FOG-2; Proliferation.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200007
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The new world of RNAs Genet. Mol. Biol.
Dogini,Danyella Barbosa; Pascoal,Vinícius D'Avila Bittencourt; Avansini,Simoni Helena; Vieira,André Schwambach; Pereira,Tiago Campos; Lopes-Cendes,Iscia.
One of the major developments that resulted from the human genome sequencing projects was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided into several different categories according to size and function; however, one shared feature is that they are not translated into proteins. In this review, we will discuss relevant aspects of ncRNAs, focusing on two main types: i) microRNAs, which negatively regulate gene expression either by translational repression or target mRNA degradation, and ii) small interfering RNAs (siRNAs), which are involved in the biological process of RNA interference (RNAi). Our knowledge regarding these two types of ncRNAs has increased dramatically over the past decade, and they have a great potential...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Non-coding RNAs; MicroRNAs; RNA interferance; RNA-based drugs.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200014
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The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis BJMBR
Slavov,S.N.; Gimenes Teixeira,H.L.; Rego,E.M..
Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; Gene expression; Leukemia; Acute lymphoblastic leukemia; T cells.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700003
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The role of microRNAs in enteroviral infections BJID
Wu,Jing; Shen,Li; Chen,Jianguo; Xu,Huaxi; Mao,Lingxiang.
ABSTRACTThe genus Enterovirus, a member of thePicornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection ofEnterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.
Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; Enterovirus; Infection.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500510
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