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Asexual Recombination in a uvsH Mutant of Aspergillus nidulans Biol. Res.
SOUZA-JÚNIOR,S A; BECKER,T C A; CASTRO-PRADO,M A A.
Mutations in the gene uvsH of Aspergillus nidulans result in increased spontaneous chromosome instability and increased intragenic and intergenic mitotic recombination in homozygous diploids. The aim of the present work was to obtain a uvs mutant of A. nidulans and to use it for the isolation of asexual recombinants (parameiotic segregants). The mutant uvsH, named B511, showed normal frequency of meiotic recombination in sexual crosses and high frequency of parameiotic segregants in the parasexual crossings with master strains (B511//A757 and B511//A288). Asexual haploid recombinants (parameiotic segregants), diploid and aneuploid segregants were recovered directly from the uvs//uvs+ heterokaryons (B511//A757 and B511// A288). Parameiotic segregants...
Tipo: Journal article Palavras-chave: Mitotic crossing-over; Parameiosis; Uvs mutation.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000100007
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Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans BJM
Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de.
Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014
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Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans BJM
Franco,Claudinéia Conationi da Silva; Miyamoto,Claudia Tiemi; Sant'Anna,Juliane Rocha de; Castro-Prado,Marialba Avezum Alves de.
Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) with chemopreventive effect on human cancer cells. Due to the involvement of the somatic recombination in the carcinogenic process, sulindac sulfide's recombinogenic potential was evaluated by the Homozygotization Index (HI) in the filamentous fungus Aspergillus nidulans. The drug's recombinogenic potential was evaluated by its capacity to induce homozygosis of recessive genes from heterozygous diploid cells. Sulindac sulfide at 175 and 350 µM concentrations induced mitotic recombination in A. nidulans diploid cells, with HI values for genetic markers higher than 2.0, and significantly different from control HI values. The recombinogenic effect of NSAID was related to the induction of DNA...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009
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