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A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability BJPS
Pedreiro,Liliane Neves; Cury,Beatriz Stringhetti Ferreira; Chaud,Marco Vinícius; Gremião,Maria Palmira Daflon.
ABSTRACT Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystallinity, thermal behavior, and liquid uptake ability. In vitro drug dissolution, mucoadhesiveness and AZT intestinal permeability were also determined. Thermal behavior and X-ray diffraction patterns demonstrated the amorphous state of AZT in SD systems. The HPMCP polymer restricted the liquid uptake ability in the acid medium; however, this...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Zidovudine; Solid dispersion; Mucoadhesion; P-glycoprotein; Intestinal permeability..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400715
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Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment BABT
Patel,Dhaval J; Patel,Jayvadan K.
The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Famotidine; Nanosuspension; Box-Behnken design; Mucoadhesion; Peptic ulcer.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200007
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Formulation and characterization of gastroretentive discs containing famotidine BABT
Raval,Jignyasha Amitkumar; Patel,Madhabhai M.
In this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine in the stomach. Various types of hydrophilic diluents were evaluated for their swelling and mucoadhesive property and one (polyvinylpyrrolidone, PVP) was selected to combine with the selected mucoadhesive polymer (polyethylene oxide, PEO). Discs with different ratios of PEO and PVP were prepared and evaluated for swelling, dissolution, and mucoadhesion. The swelling property of the discs increased as the concentration of PEO was increased and also did the mucoadhesion. These discs retained their integrity and adherence onto...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Discs; Gastroretentive; Polyethylene oxide; Polyvinylpyrrolidone.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200010
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Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon BJPS
Saxena,Ankita; Tewari,Gulab; Saraf,Shubhini Awasthi.
Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Buccal patches/drug release; Inclusion complexes/use; Acyclovir; Mucoadhesion.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400026
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Mucoadhesive drug delivery systems BJPS
Carvalho,Flávia Chiva; Bruschi,Marcos Luciano; Evangelista,Raul Cesar; Gremião,Maria Palmira Daflon.
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100002
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Mucoadhesive nanoparticles: a new perspective for fish drug application. Repositório Alice
COSTA, A. C. da S.; BRANDAO, H. de M.; SILVA, S. R. da; BENTES-SOUSA, A. R.; DINIZ JUNIOR, J. A. P.; PINHEIRO, J. de J. V.; MELO, M. de F. C. de; SILVA JUNIOR, J. O. C.; MATOS, E. R.; RIBEIRO-COSTA, R. M..
2015
Tipo: Nota Técnica/Nota Científica (ALICE) Palavras-chave: Chitosan; Fluorescein isothiocyanate; Mucoadhesion; Nanoparticle; Tambaqui; Tripoly-phosphate.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1037650
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Screening of mucoadhesive vaginal gel formulations BJPS
Andrade,Ana Ochoa; Parente,María Emma; Ares,Gastón.
Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesive vaginal gels/screening; Xanthan gum/use/vaginal products; Mucoadhesion; Vaginal products/rheology; Vaginal products/spreadability; Natural products/use/vaginal gels.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400931
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Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer BJPS
Bhalekar,Mangesh; Sonawane,Savita; Shimpi,Shamkant.
The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, disulphide group content, swelling behavior, rheological properties and mucoadhesive properties. The obtained conjugates characterized in vitro by quantification of immobilized thiol groups; showed maximum thiol incorporation on xyloglucan (7.67 ± 0.14 %) at pH 5. The disulphide group content was found maximum (2.83 ± 0.12) at pH 6. The water uptake at end of 4 h was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Thiomer; Xyloglucan; L-cysteine HCl.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200010
Registros recuperados: 8
Primeira ... 1 ... Última
 

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