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A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat BJMBR
Bonilha,A.M.M.; Saraiva,R.M.; Kanashiro,R.M.; Portes,L.A.; Antonio,E.L.; Tucci,P.J.F..
Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction size; Rats; Electrocardiogram; Echocardiogram; ROC curve.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400016
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Determination of myocardial infarction size in rats by echocardiography and tetrazolium staining: correlation, agreements, and simplifications BJMBR
Dos Santos,L.; Mello,A.F.S.; Antonio,E.L.; Tucci,P.J.F..
Triphenyltetrazolium chloride (TTC) staining and echocardiography (ECHO) are methods used to determine experimental myocardial infarction (MI) size, whose practical applicability should be expanded. Our objectives were to analyze the accuracy of ECHO in determining infarction size in rats during the first days following coronary occlusion and to test whether a simplified single measurement by TTC correctly indicates MI size, as determined by the average value for multiple slices. Infarction was induced in female Wistar rats by coronary artery occlusion and MI size analysis was performed after the acute (7th day) and chronic periods (after 4 weeks) by ECHO matched with TTC. ECHO and TTC showed similar values of MI size (% of left ventricle perimeter) in...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Myocardial infarction size; Echocardiography and triphenyltetrazolium comparison; Bland-Altman test.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300004
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Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats BJMBR
Nozawa,E.; Kanashiro,R.M.; Murad,N.; Carvalho,A.C.C.; Cravo,S.L.D.; Campos,O.; Tucci,P.J.F.; Moises,V.A..
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Myocardial infarction size; Systolic and diastolic function; Doppler echocardiography.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500016
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