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	Provedor de dados 56 (2) 48 (1) Autor MacIntosh,B.R. (2) Rassier,D.E. (2) GHATPANDE,SATISH (1) SHAFIQ,SAIYID (1) SIDDIQUI,M.A.Q. (1) Tubman,L.A. (1) Mais... Palavra-chave Myosin light chains (3) Atrophy (1) Ca2+ availability (1) Ca2+ sensitivity (1) Cardiogenesis (1) Cardiomyopathy (1) High-frequency fatigue (1) Low-frequency fatigue (1) Posttetanic potentiation (1) Potentiation (1) RLC phosphorylation (1) Staircase (1) Tetrodotoxin (TTX) (1) Tissue culture (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Journal article (1) Ano 2001 (1) 2000 (1) 1999 (1) País Brazil (2) Chile (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Coexistence of potentiation and fatigue in skeletal muscle 56 Rassier,D.E.; MacIntosh,B.R.. Twitch potentiation and fatigue in skeletal muscle are two conditions in which force production is affected by the stimulation history. Twitch potentiation is the increase in the twitch active force observed after a tetanic contraction or during and following low-frequency stimulation. There is evidence that the mechanism responsible for potentiation is phosphorylation of the regulatory light chains of myosin, a Ca2+-dependent process. Fatigue is the force decrease observed after a period of repeated muscle stimulation. Fatigue has also been associated with a Ca2+-related mechanism: decreased peak Ca2+ concentration in the myoplasm is observed during fatigue. This decrease is probably due to an inhibition of Ca2+ release from the sarcoplasmic reticulum.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Posttetanic potentiation; Staircase; High-frequency fatigue; Low-frequency fatigue; Ca2+ sensitivity; RLC phosphorylation; Myosin light chains. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500003 Staircase in mammalian muscle without light chain phosphorylation 56 Rassier,D.E.; Tubman,L.A.; MacIntosh,B.R.. In disuse atrophied skeletal muscle, the staircase response is virtually absent and light chain phosphorylation does not occur. The purpose of the present study was to determine if staircase could be restored in atrophied muscle with continued absence of myosin light chain phosphorylation, by reducing what appears to be an otherwise enhanced calcium release. Control (untreated) and sham-operated female Sprague-Dawley rats were compared with animals after 2 weeks of complete inactivity induced by tetrodotoxin (TTX) application to the left sciatic nerve. In situ isometric contractile responses of rat gastrocnemius muscle were analyzed before and after administration of dantrolene sodium (DS), a drug which is known to inhibit Ca2+ release in skeletal muscle.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potentiation; Ca2+ availability; Tetrodotoxin (TTX); Atrophy; Myosin light chains. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100018 Ventricular Myosin Light Chain-2 Gene Expression in Developing Heart of Chicken Embryos 48 GHATPANDE,SATISH; SHAFIQ,SAIYID; SIDDIQUI,M.A.Q.. Recent gene knock-out studies in mice have suggested that ventricular myosin light chain-2 (vMLC2) has a role in the regulation of cardiogenic development and that perturbation in expression of vMLC2 is linked to the onset of dilated cardiomyopathy. In an attempt to develop an avian model for such studies, we examined the expression pattern of vMLC2 in chicken embryos at various stages and analyzed the effect of antisense oligonucleotide-mediated interference of vMLC2 function in cultures of whole embryos. Our results showed vMLC2 to be a specific marker for ventricular chamber throughout chicken embryonic development and antisense vMLC2 treatment of primitive streak stage (stage 4) embryos to produce pronounced dilation of heart tube with severe... Tipo: Journal article Palavras-chave: Cardiogenesis; Cardiomyopathy; Myosin light chains; Tissue culture. Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000100009 Registros recuperados: 3 Primeira ... 1 ... Última

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