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Registros recuperados: 9
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Biological Synthesis of Selenium Nanoparticles and Evaluation of their Bioavailability BABT
Pouri,Saeedeh; Motamedi,Hossein; Honary,Soheyla; Kazeminezhad,Iraj.
ABSTRACT Nanoparticles due to their unique properties have attracted more attention and their bacterial biosynthesis is more favorable because is environmental friendly and the size and yield of nanoparticles can be optimized. The aim of the present study was biosynthesis of Selenium nanoparticles using Bacillus cereus. For this purpose, bacterial culture was prepared in the presence of sodium selenate solution and incubated (30°C, 24 h). The produced nanoparticles were purified through consequent centrifugation, washing with 0.9% NaCl, sonication, washing with Tris- HCl containing Sodium dodecyl sulfate (SDS) and finally isolation with water- octanol two phase systems. Then using Ultraviolet-Visible spectroscopy, dynamic light scattering (DLS), scaning...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bacillus cereus Green chemistry Selenium; Nanoparticle.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100456
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Cytotoxic Effect on Cancerous Cell Lines by Biologically Synthesized Silver Nanoparticles BABT
Kulandaivelu,Balaji; Gothandam,K M.
The biosynthesis of nanoparticles has been proposed as an environmental friendly and cost effective alternative to chemical and physical methods. Silver nanoparticles are biologically synthesized and characterized were used in the study. The invitro cytotoxic effect of biologically synthesized silver nanoparticles against MCF-7 cancer cell lines were assessed. The cytotoxic effects of the silver nanoparticles could significantly inhibited MCF-7 cancer cell lines proliferation in a time and concentration-dependent manner by MTT assay. Acridine orange, ethidium bromide (AO/EB) dual staining, caspase-3 and DNA fragmentation assays were carried out using various concentrations of silver nanoparticles ranging from 1 to 100 μg/mL. At 100 μg/mL concentration, the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Silver nanoparticle; Nanotechnology; Nanobiotechnology; Nanoparticle; Cytotoxicity.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100307
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Fate of Cerium Oxide Nanoparticles in Natural Waters and Immunotoxicity in Exposed Rainbow Trout ArchiMer
Gagnon, C.; Bruneau, Audrey; Turcotte, P.; Pilote, M.; Gagne, F..
Once released in the environment, engineered nanoparticles (NPs) can undergo important transformation resulting in changed properties under natural conditions. This study investigated the fate, the bioavailability and the immunotoxicity of cerium oxide (CeO2) nanoparticles in fish exposed to CeO2 in representative surface waters differing in pH, organic matter content and conductivity (green and brown waters). Following an incubation period of NP CeO2 in different surface waters, particle size distribution and shape were determined by ultrafiltration and ICP-mass spectrometry, electronic microscopy and dynamic light scattering (DSL). Bioaccumulation and effect biomarkers focusing on the immune system responses (viability of immune cells and phagocytic...
Tipo: Text Palavras-chave: Nanoparticle; Nanotoxicity; Bioaccumulation; Transformation.
Ano: 2018 URL: http://archimer.ifremer.fr/doc/00433/54422/55765.pdf
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Mucoadhesive nanoparticles: a new perspective for fish drug application. Repositório Alice
COSTA, A. C. da S.; BRANDAO, H. de M.; SILVA, S. R. da; BENTES-SOUSA, A. R.; DINIZ JUNIOR, J. A. P.; PINHEIRO, J. de J. V.; MELO, M. de F. C. de; SILVA JUNIOR, J. O. C.; MATOS, E. R.; RIBEIRO-COSTA, R. M..
2015
Tipo: Nota Técnica/Nota Científica (ALICE) Palavras-chave: Chitosan; Fluorescein isothiocyanate; Mucoadhesion; Nanoparticle; Tambaqui; Tripoly-phosphate.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1037650
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Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system J. Venom. Anim. Toxins incl. Trop. Dis.
Mohammadpour Dounighi,N; Eskandari,R; Avadi,MR; Zolfagharian,H; Mir Mohammad Sadeghi,A; Rezayat,M.
Hydrophilic nanoparticles have been widely investigated in recent years as delivery systems for therapeutic macromolecules such as antigens. In the present study Mesobuthus eupeus venom-loaded chitosan nanoparticles were prepared via ionic gelation of tripolyphosphate (TPP) and chitosan. The optimum encapsulation efficiency (91.1%) and loading capacity (76.3%) were obtained by a chitosan concentration of 2 mg/mL, chitosan-to-TPP mass ratio of 2 and M. eupeus venom concentration of 500 µg/mL. The average nanoparticle size at optimum conditions was determined by Zetasizer (Malvern Instruments, UK). The nanoparticle size was about 370 nm (polydispersity index: 0.429) while the zeta potential was positive. Transmission electron microscope (TEM) imaging showed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; Chitosan; Tripolyphosphate; Venom; Antigen delivery system; Mesobuthus eupeus.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100006
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Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide BJPS
Fattahi,Ali; Ghiasi,Mansoureh; Mohammadi,Pardis; Hosseinzadeh,Leila; Adibkia,Khosro; Mohammadi,Ghobad.
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H-NMR. Flutamide-loaded nanoparticles were prepared by quasi-emulsion solvent diffusion technique. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency, and release properties. Also, the physicochemical properties of the nanoparticles were analyzed using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry, and Powder...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; PLGA; Flutamide; Prazosin; Prostate cancer; Drug delivery.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609
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Reverse phase high-performance liquid chromatography for quantification of hydroxymethylnitrofurazone in polymeric nanoparticles BJPS
Monteiro,Lis Marie; Tavares,Guilherme Diniz; Ferreira,Elizabeth Igne; Consiglieri,Vladi Olga; Bou-Chacra,Nadia Araci; Löbenberg,Raimar.
Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome its poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems have proposed for the treatment of neglected diseases. As several studies have confirmed the advantages of such formulations, and this approach provides new analytical challenges, including the need to detect trace amounts of the drug. A suitable method was developed and validated for NFOH determination bound to poly (n-butylcyanoacrylate) (PBCA) nanoparticles. The chromatographic separation was achieved using a C18 column maintained at 25 ºC and an isocratic mobile phase consisting of water and acetonitrile:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hydroxymethylnitrofurazone/determinação; Nanoparticle; High-performance liquid chromatography/reverse phase/quantitative analysis; Poly(n-butylcyanoacrylate)/nanoparticles/encapsulation.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300561
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Soil Physicochemical and Biological Interfacial Interactions in the Rhizosphere: Impacts on Food Security and Ecosystem Integrity R.C. Suelo Nutr. Veg.
Huang,P.M.
Tipo: Journal article Palavras-chave: Rhizosphere; Climate change; Nanoparticle.
Ano: 2008 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-27912008000400005
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Subsídios técnicos para formulação do processo regulatório das nanotecnologias no Brasil: consulta a especialistas como uma abordagem preliminar. Repositório Alice
JESUS, K. R. E. de; MASSINI, K. C..
O presente trabalho visa auxiliar os legisladores quanto ao processo regulatório das nanotecnologias inseridas no mercado. Com a finalidade de identificar o melhor modo de conduzir a discussão que contribua com a regulamentação do tema no Brasil foi organizado um workshop com a presença de especialistas da comunidade científica e legisladores. Como resultado foram elaboradas questões que abordavam o processo regulatório da nanotecnologia com a finalidade de analisar o conhecimento e o posicionamento dos especialistas que estão diretamente ligados ao desenvolvimento das nanotecnologias. Essas foram disponibilizadas para 214 especialistas atuantes nas áreas correlatas da Nanotecnologia no formato de um questionário-web aplicando a Técnica Delphi, através da...
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Nanotecnologia; Avaliação de segurança; Nanoparticle; Safety assessment; Nanotechnology regulation; Regulamentação; Nanotechnology; Laws and regulations.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1085835
Registros recuperados: 9
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