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| Registros recuperados: 54 | |
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| Lima,Isabela Angeli de; Khalil,Najeh Maissar; Mainardes,Rubiana Mara. |
| ABSTRACT The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. For the chromatographic analysis, a reverse phase C-18 column was used, mobile phase consisting of acetonitrile and 0.5% acetic acid (37:63, v/v), isocratically eluted at a flow rate of 1 mL/min. Drug determination was performed at 320 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. The method was linear in the range of 10 to 100 μg/mL (r=0.999) and presented limit... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanoparticles; Ferulic acid/encapsulation efficiency; Ferulic acid/quantification; Stability; High performance liquid chromatography/validation; PLGA-poly(lactide-co-glycolide)/nanoparticles; Chitosan.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200627 |
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| Juárez-Maldonado,A; Rosales-Velázquez,JL; Ortega-Ortiz,H; Cabrera-De-la-Fuente,M; Ramírez,H; Benavides-Mendoza,A. |
| Nanotechnology is currently an important worldwide study field because it provides control on matter at a nanometric scale. In food and agricultural fields, the applications of this technology are in early stages. Onion is one of the main vegetables grown in the world. Onion is a low calorie food which contains a large amount of flavonoids. In this work, silver nitrate application in onion was evaluated. An onion crop was developed at the University Antonio Narro in Saltillo, Mexico. Two methods of silver nitrate application were used (a nutritive solution: 0, 20, 40 and 80 mg/L of AgNO3; and foliar spray: 0, 20 and 40 mg/L of AgNO3). The samples were taken at 30, 60 and 90 days after transplanting. Total antioxidant capacity, silver accumulation and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanotechnology; Onion; Silver nitrate; Nanoparticles. |
| Ano: 2013 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572013000100013 |
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| OLIVEIRA, L. P. de; LIMA, C. G. de; SIQUEIRA, M. C.; CASTRO, V. L. S. S. de. |
| A principal motivação desse trabalho é apresentar uma aplicação, em estudo toxicológico, de modelo de análise de variância com dois fatores com variâncias residuais heterogêneas, usando os procedimentos MIXED e PLM do SAS. O experimento foi conduzido no laboratório de ecotoxicologia e biossegurança da Embrapa Meio Ambiente e teve como um de seus objetivos avaliar os efeitos de sexo e dose na quantidade de nanopartículas encontradas nos tecidos dos íleos de ratos Wistar que receberam diariamente ao longo de 28 dias, via oral, doses repetidas de um nanocomposto. O modelo heteroscedástico foi ajustado usando o procedimento MIXED. Os desdobramentos da interação significativa, entre os níveis dos fatores sexo e dose, foram feitos usando o procedimento PLM que... |
| Tipo: Separatas |
Palavras-chave: Nanotecnologia; Nanopartículas; Econoxicology.; Animal de laboratório; Rato; Composto químico; Modelo matemático; Toxidez; Nanoparticles; Nanotechnology.. |
| Ano: 2014 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1007437 |
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| IANISKI,FRANCINE R.; RECH,VIRGINIA C.; NISHIHIRA,VIVIAN S.K.; ALVES,CATIANE B.; BALDISSERA,MATHEUS D.; WILHELM,ETHEL A.; LUCHESE,CRISTIANE. |
| ABSTRACT Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's disease model. Male adult Swiss mice received amyloid-β or saline. One day after, mice were treated with blank nanocapsules (17 ml/kg) or meloxicam-loaded nanocapsules (5 mg/kg) or free meloxicam (5 mg/kg). Treatments were performed on alternating days, until the end of the experimental protocol. In the fourteenth day, kinases activities were performed. Amyloid-β did not change the kinases activity in the hippocampus and cerebral cortex of mice. However, free meloxicam decrease the creatine kinase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alzheimer's disease; Nanoparticles; Meloxicam; Energetic metabolism; Phosphoryltransfer network. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501829 |
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| Dashamiri,Somayeh; Ghaedi,Mehrorang; Naghiha,Reza; Salehi,Amin; Jannesar,Ramin. |
| As there are a lot of antibacterial and anti-fungal resistant pathogens, researchers attempt to substitute antimicrobial drugs with various medical plants and novel nanoparticles. The present study was conducted to characterize antimicrobial activities of Euphorbia prostrata and Pelargonium graveolens extract alone and in combination with Mn-Ni@Fe3O4-NPs & Mn: Fe (OH)3-NPs on the DNA cleavage of E. coli and also Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Aspergillus oryzae, and Candida albicans. The effects of antimicrobial activities on above scenarios were evaluated using disc diffusion, MIC, MBC, and E. coli DNA electrophoresis methods. The results showed that the effects of antibacterial assay values of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Euphorbia prostrata/extract/antimicrobial activities; Pelargonium graveolens/extract/antimicrobial activities E coli; Candida albicans; Nanoparticles. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400625 |
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| Pedrozo,Regiellen Cristina; Antônio,Emilli; Khalil,Najeh Maissar; Mainardes,Rubiana Mara. |
| Rutin is a flavonoid compound obtained from different vegetables and fruits; specifically, it is found in the seeds of buckwheat and in fruit peels, particularly citrus. It is also an important constituent of red wine. Rutin exhibits various biological properties including antiviral, vasoprotective, anti-inflammatory, and anticarcinogenic activities. However, its antioxidant activity is the most well studied. Despite the potential for in vitro applications, rutin presents low oral bioavailability that affects its biological activities. Nanoparticles composed of polymers, protein, or lipids are of great importance in the pharmaceutical and nutraceutical areas due to their physicochemical properties, which improve the pharmacokinetics of the drug which is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nano spray drying; Rutin; Nanoparticles; Bovine serum albumin; Antioxidant. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100512 |
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| SIQUEIRA, M. C.; AOUADA, M. R. M.; CASTRO, V. L. S. S. de; BRANDÃO, H. de M.; RECH, R. R.; MARCONCINI, J. M.; MATTOSO, L. H. C.. |
| Resumo: Nanopartículas de prata foram sintetizadas, caracterizadas e incorporadas em matriz polimérica (carboximetilcelulose) para avaliação da sua toxicidade na utilização em embalagens alimentícias. A síntese foi realizada através do método de redução química de prata com borohidreto de sódio. Tamanho das partículas, permeabilidade ao vapor de água e análises térmicas foram algumas das caracterizações realizadas. Avaliação da toxicidade dessas nanopartículas sugere, inicialmente, a degeneração celular relacionada a ingestão das mesmas, feita através de teste oral agudo com posterior análise histopatológica. Teste de genotoxicidade utilizando Allium cepa como organismo teste também será realizado. |
| Tipo: Separatas |
Palavras-chave: Nanopartículas de prata; Toxicidade; Embalagens alimentícias; Toxidez; Embalagem; Nanoparticles; Toxicity; Food packaging. |
| Ano: 2013 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/963410 |
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| RIBEIRO,ANA F.; SANTOS,JULIANA F.; MATTOS,RÔMULO R.; BARROS,ELIANE G.O.; NASCIUTTI,LUIZ EURICO; CABRAL,LÚCIO M.; SOUSA,VALERIA P. DE. |
| Abstract Uncaria tomentosa (UT) extracts have been shown to have promising anti-tumor activity. We hypothesized that its incorporation into nanostructured systems could improve the anticancer properties. Here, poly-e-caprolactone (PCL) and poly-d,l-lactide-co-glycolide (PLGA) were employed to generate nanoparticles loaded with UT extract in a single emulsion solvent evaporation method. The nanoparticles were characterized by particle size, zeta potential, morphology and entrapment efficiency along with stability and release profiles. The nanoparticles presented entrapment efficiencies above 60% and a mean diameter below 300nm. UT-PCL nanoparticles presented higher entrapment efficiency and mean particle size as well as a slow release rate. The UT-PLGA... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanoparticles; Prostate cancer; PLGA; PCL; Anti-tumor; Anti-cancer; Cat’s Claw. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100908 |
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| SILVA, L. B. B. da; MARIGO, A. L. S.; CASTRO, V. L. S. S. de; JONSSON, C. M.; SIL, M. S. G. M. e. |
| Resumo: O óxido de grafeno (OG) nanoestruturado apresenta aplicações em diversas áreas e os seus usos promissores têm despertado preocupações sobre o seu risco para a saúde humana e do meio ambiente. Por sua capacidade de precipitação, os sedimentos constituem o depósito final desse contaminante. A espécie Chironomus sancticaroli é um inseto bioindicador bentônico suscetível a qualquer alteração, não só no substrato/sedimento, como também na coluna d?água. Substâncias húmicas, como ácido húmico, são macromoléculas poliméricas que estão presentes na natureza e são originarias da decomposição da biota aquática. Estas moléculas podem alterar a biodisponibilidade do OG. No presente trabalho estudaram-se os estágios de desenvolvimento de C. sancticaroli para... |
| Tipo: Separatas |
Palavras-chave: Chironomus sancticaroli; Grafeno; Bioensaio; Nanocompostos; Ecotoxicologia; Inseto; Composto químico; Matéria orgânica; Solo; Toxidez; Ecotoxicology; Graphene oxide; Nanoparticles; Aquatic invertebrates. |
| Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1063997 |
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| Rodrigues,Caroline Danziato; Khalil,Najeh Maissar; Mainardes,Rubiana Mara. |
| In this work, we developed and validated an effective reversed-phase HPLC method with photodiode array (PDA) detection for the quantitative analysis of amphotericin B (AmB) in poly(lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles. Chromatographic runs were performed on a reverse phase C18 column using a mobile phase comprising a 9% acetic acid and acetonitrile mixture (40:60, v/v) under isocratic elution with a flow rate of 1 mL/min. AmB was detected at a wavelength of 408 nm. The validation process was performed considering the selectivity, linearity, precision, accuracy, robustness, limit of detection (LOD) and limit of quantitation (LOQ) of the method. A concentration range of 1-20 µg/mL was used to construct a linear calibration curve. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amphotericin B/determination; Amphotericin B/encapsulation; High performance liquid chromatography/reverse phase/quantitative analysis; Nanoparticles. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400859 |
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| Guan,Jiao; Han,Liqin; Shi,Nianqiu; Zhu,Heyun; Wang,Junmin. |
| Docetaxel-loaded acetic acid conjugated Cordyceps sinensis polysaccharide (DTX-AA-CSP) nanoparticles were prepared through dialysis and their release rates in vitro, particle sizes, zeta potentials, drug loading capacities, and encapsulation efficiencies were characterized for the synthesis of AA-modified CSPs from traditional Chinese medicine Cordyceps sinensis (Berk.) Sacc. Then, the AA-modified CSPs were characterized by 1H-NMR and FT-IR. Furthermore, the biocompatibility of the delivery carrier (AA-CSP nanoparticles) was assessed on human umbilical vein endothelial cells. In vitro antitumor activity studies on DTX-AA-CSP nanoparticles were conducted on the human liver (HepG2) and colon cancer cells (SW480). The DTX-AA-CSP nanoparticles were spherical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Docetaxel; Cordyceps sinensis polysaccharide; Nanoparticles; Antitumor efficacy; Biocompatibility. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100599 |
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| Romero Pérez, Atmir. |
| El selenito de sodio, el suplemento de selenio mas usado en rumiantes en la prevención de la deficiencia del elemento y las enfermedades resultantes, fue encapsulado por nanoprecipitación y emulsión-evaporación en nanopartículas poliméricas. Fue evaluado el efecto del método de preparación de nanoparticulas, proporciones de polímeros (Eudragit RL 100 y RS 100) y solvente empleado (etanol y acetona), sobre las características fisicoquímicas (potencial z, índice de polidispersidad y porcentaje de encapsulación) y la morfología (tamaño de partícula y forma) de las nanopartículas. El tamaño de partícula obtenido presentó valores de 34.64 a 213.86 nm. Tanto el tamaño como el potencial z y el PDI se incrementaron (P < 0.05) cuando se utilizó el... |
| Tipo: Tesis |
Palavras-chave: Nanopartículas; Selenito de sodio; Eudragit; Rumiantes; Maestría; Ganadería; Nanoparticles; Sodium selenite; Eudragit; Ruminants. |
| Ano: 2008 |
URL: http://hdl.handle.net/10521/1515 |
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| LUIS, A. I. S.; CAMPOS, E. V. R.; OLIVEIRA, J. L. de; VALLIM, J. H.; PROENÇA, P. L. de F.; CASTANHA, R. F.; CASTRO, V. L. S. S. de; FRACETO, L. F.. |
| Abstract: Background: Ascorbic acid (AA) is a micronutrient essential for the mechanisms of reproduction, growth, and defense in fish. However, the biosynthesis of this micronutrient does not occur in fish, so it must be supplied with food. A difficulty is that plain AA is unstable, due to the effects of light, high temperature, and oxygen, among others. The use of nanoencapsulation may provide protection and preserve the physicochemical characteristics of AA for extended periods of time, decreasing losses due to environmental factors. Method: This study evaluated the protective effect of nanoencapsulation in polymeric nanoparticles (chitosan and polycaprolactone) against AA degradation. Evaluation was made of the physicochemical stability of the... |
| Tipo: Artigo de periódico |
Palavras-chave: Polycaprolactone nanoparticles; Zebrafish; Nanopartículas de quitosana; Nanoencapsulação.; Toxidez.; Aquicultura; Peixe de Água Doce; Vitamina C; Ascorbic acid; Vitamin supplements; Danio rerio; Nanoparticles; Chitosan; Toxicity.. |
| Ano: 2021 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1133729 |
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| ASSALIN, M. R.; SANTOS, L. D. L. dos; SOUZA, D. R. C. de; ROSA, M. A.; MOLTOCARO, R. C. R.; CASTANHA, R. F.; DONAIRE, P. P. R.; DURAN, N.. |
| Abstract: The transmission of Huanglongbing (HLB) disease on citrus plants is through dissemination of the bacteria Candidatus Liberibacter ssp, by Diaphorina citri psyllid, its insect vector. Chemical control of the psyllids, and thiamethoxam (neonicotinoid insecticide) is one of the active ingredients used in the control of HLB. This insecticide is water soluble, unstable and rapidly degraded by photolysis. Pesticide nanoformulation is one of the strategies to control release of active compound as well as protection for premature degradation. Thus, studies of the effectiveness of encapsulated pesticide formulations are extremely important for enabling its use in agriculture. This study reports the encapsulation of the insecticide thiamethoxam in... |
| Tipo: Artigo de periódico |
Palavras-chave: Nanopesticides; Nanopesticidas; Inseticida; Toxidez; Nanoparticles; Pesticides; Toxicity; Ecotoxicology. |
| Ano: 2019 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1115617 |
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| PEREIRA, R. M. S.; PERTRINI, F. S.; CASTANHA, R. F.; CASTRO, V. L. S. S. de; JONSSON, C. M.. |
| Resumo: As nanopartículas de prata (AgNP) vêm despertando grande interesse no meio científico por possuírem propriedades importantes, tais como, condutividade elétrica e térmica, atividade catalítica, flexibiliade, estabilidade química, maleabilidade e o baixo custo de produção. Apesar do desempenho em diferentes função, estudos têm alertados sobre os possíveis efeitos que a AgNP pode causar ao meio ambiente decorrente do aumento de sua produção e utilização. A Lemna minor (Lentilha-de-água) é uma macrófita encontrada em água doce e normalmente utlizada em testes de ecotoxicidade de poluentes ambientais. Este estudo teve como objetivo avaliar os efeitos da AgNP estabilizada em polivinil álcool (PVA) sobre o crescimento, teor de clorofila e massa da matéria... |
| Tipo: Anais e Proceedings de eventos |
Palavras-chave: Macrófita; Ecotoxicologia; Nanotoxicologia; Nanoprata; Toxicidade; Nanomaterial.; Planta Aquatica; Composto Químico; Impacto Ambiental; Toxidez; Nanoparticles; Nanosilver; Environmental impact; Ecotoxicology; Lemna minor. |
| Ano: 2021 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1138610 |
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| Registros recuperados: 54 | |
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