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Última Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products 58 Soares,Luciana Arantes; Sardi,Janaína de Cássia Orlandi; Gullo,Fernanda Patrícia; Pitangui,Nayla de Souza; Scorzoni,Liliana; Leite,Fernanda Sangalli; Giannini,Maria José Soares Mendes; Almeida,Ana Marisa Fusco. Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments. Tipo: Info:eu-repo/semantics/article Palavras-chave: Dermatophytes; Filamentous fungi; Natural products; Synthetic product. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400003 Antifungal activity of selected plant extracts based on an ethnodirected study 39 Silva,Flávia dos Santos; Landell,Melissa Fontes; Paulino,Gustavo Vasconcelos Bastos; Coutinho,Henrique Douglas Melo; Albuquerque,Ulysses Paulino. ABSTRACT Plants have been reported as used by local populations to treat various infections for a long time, which has directed several pharmacological studies. The main aim of this work was to evaluate three plant selection criteria with better predictive power to detect extracts with antifungal action: (1) medicinal plants that are not used for indications of infection and inflammation; (2) plants with direct citations for inflammation, except for infection; (3) plants with direct citations for inflammation and infection selected quantitatively by Syndromic Importance Value (SIV). We tested the action of 23 hydroethanolic extracts of plants against the fungi Candida albicans, Cryptococcus neoformans, and Cryptococcus gattii and found no differences in... Tipo: Info:eu-repo/semantics/other Palavras-chave: Antifungal activity; Ethnobotany; Ethnopharmacology; Natural products; Local medical systems. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062020000200442 Anti-inflammatory activity of propolis extracts: a review 79 Almeida,E. C. de; Menezes,H.. Since primeval times, the inflammatory process has been described in many different ways. Several anti-inflammatory therapies have been used in different biological models. However, in a recent "back to nature move", modern man is searching for natural products with medicinal properties, particularly those obtained from plants and bees. Propolis has been used in folk medicine for a very long time. The many compounds present in propolis require investigation.Physical-chemical analysis studies have not sufficiently established quality standards of propolis containing products. These standards should depend especially on their different pharmacological activities. There are few studies reporting on the in vitro anti-inflammatory activity of propolis... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propolis; Anti-inflammatory activity; Bees; Apis mellifera; Natural products. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000200002 Antileishmanial activity of extracts from Libidibia ferrea: development of in vitro and in vivo tests 36 COMANDOLLI-WYREPKOWSKI,Claudia Dantas; JENSEN,Bruno Bezerra; GRAFOVA,Iryna; SANTOS,Pierre Alexandre dos; BARROS,Angela Maria Comapa; SOARES,Fabiane Veloso; BARCELLOS,José Fernando Marques; SILVA,Aline Fagundes da; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. ABSTRACT Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extract of L. ferrea on golden hamsters infected with L. (L.) amazonensis. Extracts from leaves, branches and fruits of L. ferrea were obtained with hexane and methanol and were tested by in vitro assays in promastigotes and murine macrophages J774... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cutaneous leishmaniasis; Natural products; Topical formulations; Experimental treatment. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000400331 Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris 42 Antinarelli,Luciana M.R.; Pinto,Nícolas C.; Scio,Elita; Coimbra,Elaine S.. Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazil; Casearia sylvestris; Leishmanicidal activity; Medicinal plants; Natural products. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733 Antimicrobial activity of honeys from two stingless honeybee species and Apis mellifera (Hymenoptera: Apidae) against pathogenic microorganisms 36 Cruz,Carolinie Batista Nobre da; Pieri,Fabio Alessandro; Carvalho-Zilse,Gislene Almeida; Orlandi,Patrícia Puccinelli; Nunes-Silva,Carlos Gustavo; Leomil,Luciana. Honeys are described possessing different properties including antimicrobial. Many studies have presented this activity of honeys produced by Apis mellifera bees, however studies including activities of stingless bees honeys are scarce. The aim of this study was to compare the antimicrobial activity of honeys collected in the Amazonas State from Melipona compressipes, Melipona seminigra and Apis mellifera against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Chromobacterium violaceum, and Candida albicans. Minimum inhibitory concentrations were determined using the agar dilution method with Müller-Hinton agar (for bacteria) or Saboraud agar (for yeast). Staphylococcus aureus and E. faecalis were inhibited by all honeys at concentrations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Melipona; Antibacterial; Antifungal; Natural products; Functional food. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200015 Antimycobacterial susceptibility testing methods for natural products research 58 Sánchez,Juan Gabriel Bueno; Kouznetsov,Vladimir V.. The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need of continuous developments on new and efficient methods to determine the susceptibility of isolates of M. tuberculosis in the search for novel antimicrobial agents. Natural products constitute an important source of new drugs, but design and implementation of antimycobacterial susceptibility testing methods are necessary for evaluate the different extracts and compounds. A number of biological assay methodologies are in current use, ranging from the classical disk diffusion and broth dilution assay format, to radiorespirometric (BACTEC), dye-based, and fluorescent/luminescence reporter assays. This review presents an analysis on the in vitro susceptibility... Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural products; M. tuberculosis; Susceptibility testing. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000200001 Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers 60 Durairaj,Brindha; Dorai,Arthi. Nelumbo nucifera Gaertn (Nelumbonaceae) a plant used in Ayurvedic medicine (common name: lotus), is a perennial, large and rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white and pink Nelumbo nucifera flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of Nelumbo nucifera flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of both types of flowers was studied using platelet-rich plasma in different concentrations (100-500µg/ml). Both white and pink Nelumbo nucifera flower extracts showed dose-dependent effective antiplatelet activity with maximum activity at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nelumbo nucifera Gaertn/phytochemical constituents; Nelumbo nucifera Gaertn/pharmacognosy; Nelumbo nucifera Gaertn/Antiplatelet activity; Ayurvedic medicine; Natural products; Aspirin. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300023 Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus 80 Silva,Ara; Morais,SM; Marques,MMM; Lima,DM; Santos,SCC; Almeida,RR; Vieira,IGP; Guedes,MIF. In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural products; Phenols; Dengue; Antiviral agents. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007 Biflorin: an o-naphthoquinone of clinical significance 42 WISINTAINER,GABRIELLE G.N.S.; SIMÕES,EVELYNE R.B.; LEMOS,TELMA L.G.; MOURA,SIDNEI; SOUZA,LUCIANA G.S.; FONSECA,ALUISIO M.; MORAES,MANOEL ODORICO; PESSOA,CLAUDIA; ROESCH-ELY,MARIANA; HENRIQUES,JOÃO A.P.. Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest... Tipo: Info:eu-repo/semantics/article Palavras-chave: Biological activity; Biflorin; Capraria biflora; Natural products. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907 Bioactivity of the latex from Parahancornia amapa (Apocynaceae) on the development of Rhodnius nasutus (Hemiptera, Reduviidae, Triatominae) under laboratory conditions 92 Lopes,Marcio B. P.; Mendonça,Paloma M.; Mallet,Jacenir R. S.; Carvalho,Mário G.; Queiroz,Margareth M. C.. Bioactivity of the latex from Parahancornia amapa (Apocynaceae) on the development of Rhodnius nasutus (Hemiptera, Reduviidae, Triatominae) under laboratory conditions. The aim of this study was to verify the effects of the methanolic fraction of the latex from Parahancornia amapa (Apocynaceae) (PALAM) on individuals of the species Rhodnius nasutus Stål (Hemiptera, Triatominae). Many of the insects treated with the substance presented deformities and these may interfere in the feeding and possibly hinder the reproductive capacity. They also presented significant mortality during the molt when compared to the control group, noting a gradual increase in mortality. The treated insects also presented delayed nymphal development (5th instar) and higher adult... Tipo: Info:eu-repo/semantics/article Palavras-chave: Laboratory; Conditions; Natural products; PALAM; Triatomine; Vector control. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262014000400012 Comparative Microbicidal Efficacy of Fractionated Extracts from In Vitro and In Vivo Raised Cells of Tinosporacordifolia Against MDR Pathogens 52 Mittal,Jitendra; Singh,Abhijeet; Batra,Amla; Sharma,Madan Mohan. The present study was conducted to explore the hidden potential of natural products synthesized in the medicinal plant Tinosporacordifolia. This plantis prioritized by National Medicinal Plant Board, New Delhi. Leaf and inter nodal segments were inoculated on MS Medium fortified with IBA (1.0 mg/L) produced callus after four weeks. The calli were brown due to phenolic substance secreted by the explant. This problem was overcome by using adjuvant PVP (0.1%). Further, secondary metabolites were isolated from callus and field leaf through soxhlet extractor and fractionated by using column chromatography. The antibacterial activity of these fractioned extracts from Tinosporacordifolia callus and leaf were seen against multi drug resistance bacteria viz.,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Callus; Natural products; PVP; Antimicrobial activity. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100406 Composition and Bioactive Properties of Yerba Mate (llex paraguariensis A. St.-Hil.): A Review 117 Burris,Kellie P; Harte,Federico M; Michael Davidson,P; Neal Stewart Jr,C; Zivanovic,Svetlana. Yerba Mate is a popular tea beverage produced and consumed in the South American countries of Argentina, Brazil, Chile, Paraguay, and Uruguay, and is processed from the leaves and stems of Ilex paraguariensis A. St.-Hil., a perennial shrub from the Aquifoliaceae family. Production occurs in six stages: harvesting older leaves and small stems, roasting by direct fire, drying under hot air, milling to specified size, aging to acquire optimal sensory attributes, and final packaging. While grown and consumed for centuries in South America, its popularity is increasing in the United States because of demand by consumers for healthier, more natural foods, its filling a niche for a different type of tea beverage, and for Yerba Mate's potential health benefits -... Tipo: Journal article Palavras-chave: Antioxidant; Antimicrobials; Natural products; Yerba mate; Tea. Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392012000200016 Controle de Colletotrichum gloeosporioides em mamoeiro, utilizando extratos vegetais, indutores de resistência e fungicida - DOI: 10.4025/actasciagron.v30i3.3500 1 Nascimento, Luciana Cordeiro do; Universidade Federal da Paraíba; Nery, Aparecida Rodrigues; UFP; Rodrigues, Luís Nery; UFCG. O presente trabalho teve como objetivo avaliar o controle de doenças do mamoeiro, utilizando extratos vegetais (alho, angico e manjericão), óleos naturais (urucum e algodão), indutores de resistência (Bion®, Ecolife® e Agro-mos®) e fungicida Mancozeb/Dithane. O Experimento I consistiu-se da avaliação dos tratamentos sobre o crescimento micelial de Colletotrichum gloeosporioides, in vitro; no Experimento II, efetuou-se a inoculação artificial do fungo sobre frutos sadios de mamão e avaliou-se a severidade da podridão peduncular, por meio de escala de notas e, no Experimento III, aplicaram-se os tratamentos em mudas de mamoeiro, inoculadas artificialmente com C. gloeosporioides, avaliando-se a antracnose com escala de notas. Os resultados obtidos... Palavras-chave: 5.01.00.00-9 Agronomia Carica papaya L.; Antracnose; Produtos naturais; Pós-colheita Fitossanidade Carica papaya L.; Anthracnose; Natural products; Postharvest. Ano: 2008 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/3500 Deacylative alkylation (DaA) of N-methyl-3-acetyl-2-oxindole for the synthesis of symmetrically 3,3-disubstituted 2-oxindoles. An access gate to anticancer agents and natural products. 42 MORENO-CABRERIZO,CRISTINA; ORTEGA-MARTÍNEZ,AITOR; MOLINA,CYNTHIA; NÁJERA,CARMEN; SANSANO,JOSÉ M.. ABSTRACT The synthesis of 3,3-disubstituted N-methyloxindoles, starting from 3-acetyl-2-hydroxy-1-methyloxindole employing a sequential one-pot synthesis, is studied. The process involves a first alkylation in the presence of 1 equiv. of both organic halide and Triton B and the second one employs another 1.5 equiv. of each in moderate to high yields. This procedure is compared with the results obtained from the direct dialkylation of N-methyloxindole. The metathesis of one of the corresponding diallylated product was also studied obtaining the spiranic oxindole. All these methodologies are directed towards the access to anticancer agents and natural biologically active products. Tipo: Info:eu-repo/semantics/article Palavras-chave: Deacylation; Alkylation; 2-oxindoles; Metathesis; Anticancer; Natural products. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301089 Effects of Nitrogen Availability on the Antioxidant Activity and Carotenoid Content of the Microalgae Nephroselmis sp 5 Coulombier, Noémie; Nicolau, Elodie; Le Déan, Loic; Barthelemy, Vanille; Schreiber, Nathalie; Brun, Pierre; Lebouvier, Nicolas; Jauffrais, Thierry. Nephroselmis sp. was previously identified as a species of interest for its antioxidant properties owing to its high carotenoid content. In addition, nitrogen availability can impact biomass and specific metabolites’ production of microalgae. To optimize parameters of antioxidant production, Nephroselmis sp. was cultivated in batch and continuous culture conditions in stirred closed photobioreactors under different nitrogen conditions (N-repletion, N-limitation, and N-starvation). The aim was to determine the influence of nitrogen availability on the peroxyl radical scavenging activity (oxygen radical absorbance capacity (ORAC) assay) and carotenoid content of Nephroselmis sp. Pigment analysis revealed a specific and unusual photosynthetic system with... Tipo: Text Palavras-chave: Lutein; Natural products; Nutrients; Peroxyl radical; Siphonaxanthin. Ano: 2020 URL: https://archimer.ifremer.fr/doc/00645/75699/76604.pdf Endophytic Fungi as Novel Resources of natural Therapeutics 52 Rajamanikyam,Maheshwari; Vadlapudi,Varahalarao; amanchy,Ramars; Upadhyayula,Suryanarayana Murty. ABSTRACT Fungal endophytes constitute a major part of the unexplored fungal diversity. Endophytic fungi (EF) are an important source for novel, potential and active metabolites. Plant-endophyte interaction and endophyte -endophyte interactions study provide insights into mutualism and metabolite production by fungi. Bioactive compounds produced by endophytes main function are helping the host plants to resist external biotic and abiotic stress, which benefit the host survival in return. These organisms mainly consist of members of the Ascomycota, Basidiomycota, Zygomycota and Oomycota. Recently, the genome sequencing technology has emerged as one of the most efficient tools that can provide whole information of a genome in a small period of time.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endophytic fungi; Ascomycota; Natural products; Antidiabetic. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100430 Essential oil from Chenopodium ambrosioides L.: secretory structures, antibacterial and antioxidant activities 3 Santiago, Juliana Andrade; Cardoso, Maria das Graças; Batista, Luís Roberto; Castro, Evaristo Mauro de; Teixeira, Maria Luisa; Pires, Marinês Ferreira. The aim of this study was to evaluate the antibacterial and antioxidant activities of essential oil from Chenopodium ambrosioides L. and to determine its secretory structures. The essential oil was extracted through the hydrodistillation technique using a modified Clevenger apparatus (2 hours) and chemically characterized by GC/MS and GC-FID. The antioxidant activity was determined by monitoring the reduction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and by the oxidation of the β-carotene/linoleic acid system. The evaluation of antibacterial activity was performed by the agar cavity diffusion technique using the microorganisms Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella Cholerasuis. The characterization of trichomes was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural products; Antioxidant assays; Antimicrobial; Trichomes. Ano: 2016 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/28303 Etude de nouvelles cibles moleculaires de cancer bronchopulmonaire non a petites cellules pharmacomodulées par des substances originales naturelles et synthetiques 5 Moreau, Dimitri. Still rare disease at the beginning of the 20th century, the lung cancer is at the origin of more than 6 % of the deaths in France currently. It occupies there the first rank of the deaths by cancer whereas France is regarded as a country at the average risk among the Western countries. The discovery of new anti-cancer treatments increasingly more effective and specific, is thus today of primary importance. The validation of the capacity of a molecule to being able to inhibit the cancerous proliferation, passes by several stages of tests starting with the description of an activity at the cellular level. One of the strategies used for the discovery of new compounds antiproliferativs, passes by an investigation of the bioactiv potential of a great number... Tipo: Text Palavras-chave: Microalgae; Natural products; Apoptosis; Antiproliferativ; Gene expression; Regulatory RNA; Molecular targets; Bronchopulmonary cancer; Microalgues; Molécules naturelles; Apoptose; Antiprolifératif; Expression génique; ARN régulateur; Cibles moléculaires; Cancer bronchopulmonaire. Ano: 2006 URL: http://archimer.ifremer.fr/doc/2006/these-2196.pdf Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field 60 Paiva,Lívia Brenelli de; Goldbeck,Rosana; Santos,Wanderley Dantas dos; Squina,Fabio Marcio. Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ferulic acid/properties; Ferulic acid/antioxidant activity; Ferulic acid/dietary sources; Ferulic acid/therapeutic effects; Natural products; Pharmacognosy. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300002 Registros recuperados: 49 Primeira ... 1 2 3 ... Última

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