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Functional role of a specific ganglioside in neuronal migration and neurite outgrowth BJMBR
Mendez-Otero,R.; Santiago,M.F..
Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuronal migration; Gangliosides; Development; 9-O-acetyl GD3; Neurite outgrowth.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006
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Immunohistochemical Study of Acute Effects of Ethanol on Midbrain of Wistar Rats Associated with the Date of Birth of Neurons in Encephalon International Journal of Morphology
Lopes,Danielly Bandeira; Nascimento,Guilherme Nobre Lima do; Carvalho,Adryano Augustto Valladão de; Souza Neto,Advaldo Carlos de; Lima,Natácia Evangelista de; Aversi-Ferreira,Tales Alexandre.
The verification of the acute effects of ethanol on the midbrain, which neurons are mainly formed in E14, will ratify if the acute effects of ethanol are associated, in terms of prevalence, to the date of birth of neurons in certain regions of the brain. The aim of this study was to determine the effects of acute exposure to ethanol on the neuronal density of the midbrain and to associate these results with acute effects of ethanol in other regions of the brain under the same conditions. The rats were treated with intraperitoneal ethanol during one day (E12) and 1h after the last ethanol injection was applied to BrdU. The animals were sacrificed; the brains were removed and sectioned. The sections were treated with DAB for the BrdU revelation, the slides...
Tipo: Journal article Palavras-chave: Ethanol; Brain; Midbrain; Neuronal migration; Fetal Alcohol Syndrome.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300009
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Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth Anais da ABC (AABC)
TARDY,MARCIENNE.
The mechanisms involved in the failure of an adult brain to regenerate post-lesion remain poorly understood. The reactive gliosis which occurs after an injury to the CNS and leads to the glial scar has been considered as one of the major impediments to neurite outgrowth and axonal regeneration. A glial scar consists mainly of reactive, hypertrophic astrocytes. These reactive cells acquire new properties, leading to A non-permissive support for neurons. Astrogial reactivity is mainly characteriized by a high overexpression of the major component of the gliofilaments, the glial fibrillary acidic protein (GFAP). This GFAP overexpression is related to the astroglial morphological response to injury. We hypothesized that modulation of GFAP synthesis, reversing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Astrogliosis; Neuro-glia interactions; Neurite outgrowth; Neuronal migration; Laminin; Metalloproteinases.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000400009
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