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An electronic pressure-meter nociception paw test for mice BJMBR
Cunha,T.M.; Verri Jr.,W.A.; Vivancos,G.G.; Moreira,I.F.; Reis,S.; Parada,C.A.; Cunha,F.Q.; Ferreira,S.H..
The aim of the present investigation was to describe and validate an electronic mechanical test for quantification of the intensity of inflammatory nociception in mice. The electronic pressure-meter test consists of inducing the animal hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer. This method was compared to the classical von Frey filaments test in which pressure intensity is automatically recorded after the nociceptive hindpaw flexion reflex. The electronic pressure-meter and the von Frey filaments were used to detect time versus treatment interactions of carrageenin-induced hypernociception. In two separate experiments, the electronic pressure-meter was more sensitive than...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Nociception; Indomethacin; Dipyrone; Von Frey filaments.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300018
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An electronic pressure-meter nociception paw test for rats BJMBR
Vivancos,G.G.; Verri Jr.,W.A.; Cunha,T.M.; Schivo,I.R.S.; Parada,C.A.; Cunha,F.Q.; Ferreira,S.H..
The objective of the present investigation was to compare the sensitivity of an electronic nociceptive mechanical paw test with classical mechanical tests to quantify the intensity variation of inflammatory nociception. The electronic pressure-meter test consists of inducing the hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer. This method was compared with the classical von Frey filaments test and with the rat paw constant pressure test, a modification of the Randall and Selitto test developed by our group. When comparing the three methods, the electronic pressure-meter and the rat paw constant pressure test, but not the von Frey filaments test, detected time vs treatment...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Nociception; Dipyrone; Indomethacin; Von Frey filaments; Constant pressure test.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300017
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An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice BJMBR
Magro,D.A.C.; Hohmann,M.S.N.; Mizokami,S.S.; Cunha,T.M.; Alves-Filho,J.C.; Casagrande,R.; Ferreira,S.H.; Liew,F.Y.; Cunha,F.Q.; Verri Jr,W.A..
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Interleukin-33; ST2; Pain; Nociception; Inflammation.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000700601
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Analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum BABT
Del-Vechio-Vieira,Glauciemar; Sousa,Orlando Vieira de; Miranda,Mariza Abreu; Senna-Valle,Luci; Kaplan,Maria Auxiliadora Coelho.
The chemical composition, analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum were investigated. The main compounds found in the essential oil were germacrene D, α-humulene and β-cedrene. The oil, with LD50 of 2.50 g/kg, inhibited the acetic acid-induced writhing at the dose of 200 mg/kg. In the formalin test, the oil inhibited the first phase (200 mg/kg) and the second phase (100 mg/kg and 200 mg/kg). In the hot plate test, after 30 and 60 min of treatment the doses of 100 and 200 mg/kg increased the reaction time. The antiedematogenic effect, reduction on the exudate volume and leukocyte mobilization were observed at the doses of 100 and 200 mg/kg. The results indicated that A. fastigiatum possessed the analgesic and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ageratum fastigiatum; Essential oil; Nociception; Inflammation.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000500008
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Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study BJMBR
Cardoso,L.C.P.; Pinto,N.B.; Nobre,M.E.P.; Silva,M.R.; Pires,G.M.; Lopes,M.J.P.; Viana,G.S.B.; Rodrigues,L.M.R..
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Edema was induced by an intraplantar injection of carrageenan and measured by plethysmography. The Hargreaves test was used to evaluate the antinociceptive activity and investigate the action of phonophoresis on tumor necrosis factor (TNF)-α production. A histological analysis with hematoxylin-eosin was used...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phonophoresis; Ultrasonic therapy; Inflammation; Nociception; Physiotherapy.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200603
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Antinociception synergy between the peripheral and spinal sites of the heme oxygenase-carbon monoxide pathway BJMBR
Nascimento,C.G.O.; Branco,L.G.S..
We have shown that the peripheral and spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase-cGMP pathways play an important role in antinociception in the rat experimental formalin model. Our objective was to determine if there is synergism between peripheral (paw) and spinal HO-CO pathways in nociception. Rats were handled and adapted to the experimental environment for a few days before the formalin test, in which 50 µL of a 1% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The animals were then observed for 1 h and the frequency of flinching behavior was taken to represent the nociceptive response. Thirty minutes before the test, rats were pretreated with intrathecal injections of the HO...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nociception; Carbon monoxide; Formalin; Hypernociception; Antinociception.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100020
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Antinociceptive and Anti-inflammatory Activities of Marine Sponges Aplysina Caissara, Haliclona sp. and Dragmacidon Reticulatum BABT
Hort,Mariana Appel; Silva Júnior,Flavio Manoel Rodrigues da; Garcia,Edariane Menestrino; Peraza,Gianni Goulart; Soares,Andrea; Lerner,Clea; Muccillo-Baisch,Ana Luiza.
ABSTRACT Marine sponges are a rich source of bioactive natural products with multiple pharmacological properties. In this study, the anti-inflammatory and antinociceptive effects of extracts obtained from Aplysina caissara, Haliclona sp. and Dragmacidon reticulatum were evaluated by using the writhing test and formalin-induced mouse paw edema model in mice. All extracts were administered via oral pathway in the doses of 60 and 90 mg/kg. In the writhing test the pre-treatment with all sponges resulted in significant inhibition of the acetic acid-induced response, suggesting an antinociceptive effect. The formalin test showed that the extracts from A. caissara, Haliclona sp. and D. reticulatum, in the tested doses, did not affect the first formalin phase,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Inflammation; Nociception; Marine sponges.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100433
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Antinociceptive effects of the essential oil of Mentha x villosa leaf and its major constituent piperitenone oxide in mice BJMBR
Sousa,P.J.C.; Linard,C.F.B.M.; Azevedo-Batista,D.; Oliveira,A.C.; Coelho-de-Souza,A.N.; Leal-Cardoso,J.H..
Mentha x villosa Huds (Labiatae) is an aromatic herb widely used in folk medicine. Since the essential oil of the herb has many pharmacological activities, including antispasmodic effects, we determined whether the oil and its major constituent, piperitenone oxide (PO), have antinociceptive activity. The essential oil of M. x villosa (EOMV) and PO administered orally at 200 mg/kg (vehicle: 0.1% Tween 80 in water) significantly reduced the writhings induced by acetic acid from control values of 59.5 ± 3.1 s (N = 10) to 31.9 ± 2.8 s (N = 10) and 23.8 ± 3.4 s (N = 10), respectively. When administered at 100 and 200 mg/kg, EOMV reduced the paw licking time for the second phase of the formalin test from the control value of 20.6 ± 2.1 s (N = 13) to 5.3 ± 2.2 s...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Mentha x villosa essential oil; Analgesia; Nociception; Anti-inflammatory effect; Piperitenone oxide.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700010
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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil Anais da ABC (AABC)
SILVA,GABRIELA L. DA; LUFT,CAROLINA; LUNARDELLI,ADROALDO; AMARAL,ROBSON H.; MELO,DENIZAR A. DA SILVA; DONADIO,MÁRCIO V.F.; NUNES,FERNANDA B.; AZAMBUJA,MARCOS S. DE; SANTANA,JOÃO C.; MORAES,CRISTINA M.B.; MELLO,RICARDO O.; CASSEL,EDUARDO; PEREIRA,MARCOS AURÉLIO DE ALMEIDA; OLIVEIRA,JARBAS R. DE.
Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidants; Inflammation; Lavender; Nociception.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301397
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Clinical, behavioral and antinociceptive effects of crotalphine in horses Ciência Rural
Guirro,Erica Cristina Bueno do Prado; Perotta,João Henrique; Paula,Márcio de; Cury,Yara; Valadão,Carlos Augusto Araújo.
ABSTRACT: Crotalphine is a novel analgesic peptide that acts on kappa opioid and delta receptors, causing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic models of pain. This study evaluated clinical, behavioral and antinociceptive effects caused by crotalphine in horses, employing 18 Arabian horses and it was divided in three phases. In Phase I, "clinical and behavioral effects", crotalphine did not change the latency to urinate and defecate; did not modify the values of cardiac or respiratory rates, intestinal motility and rectal temperature; and did not cause significant ataxia, head, eye and lip ptosis. In Phase II, "antinociceptive effect on intact skin at scapular or ischial region", crotalphine did not cause...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotalphine; Horses; Kappa; Nociception; Opioids.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000400694
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Comparative study of the sedative and antinociceptive effects of levomepromazine, azaperone and midazolam in laboratory animals Arq. Bras. Med. Vet. Zootec.
Mataqueiro,M.I.; D’Angelis,F.H.F.; De-Caroli-Neto,A.; Rossi,C.A.; Queiroz-Neto,A..
The sedative and antinociceptive effects of levomepromazine, azaperone and midazolam were studied in rats and mice using three behavior evaluation methods. Both exploratory behavior and spontaneous locomotor activity were significantly diminished in a spontaneous locomotor activity test in open field when using levomepromazine and azaperone. However, the azaperone effects were short lived in comparison to levomepromazine effects. Midazolam caused reduction in exploratory activity with no effect in spontaneous locomotion. When assessing the antinociceptive effect in the tail flick reflex latency test after infliction of a pain stimulus in rats, tested drugs did not show any antinociceptive effect. The drugs studied were able to abolish the writhing reflex...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sedation; Nociception; Levomepromazine; Azaperone; Midazolam.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000300009
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Effect of pain related of sex and estrous cycle on blood plasma glucose, free fatty acids and corticosterone in rats - doi: 10.4025/actascibiolsci.v34i4.10568 Biological Sciences
Moraes, Elzira Diniz de; Instituto de Ensino Superior de Londrina; Zaia, Cássia Thaís Bussamra Vieira; Universidade Estadual de Londrina; Zaia, Dimas Augusto Morozin; Universidade Estadual de Londrina; Santos, Angelo Alexander Torres dos; Universidade Estadual de Londrina; Ribeiro, Rachel Cezar de Andrade; Universidade Estadual de Londrina; Silva, Andreia Lopes da; Universidade Estadual de Londrina.
Sex differences related with pain have been studied and evidences suggesting influence of sex steroid hormones on the thresholds of pain. Experimental nociception has been test using formalin as a model of nociceptive stimulus. Association of stress, pain and metabolic and hormonal changes has not been explored. The aim of this study was to compare metabolic and hormonal changes between male rats and female rats in proestrus and estrus cycle after painful stimulus by formalin into the masseter muscle. Male and female Wistar rats (200-250 g b.w.) were submitted to an injection of formalin (F, 1.5%) or saline (S, 9.9%) into the masseter muscle and after 0 (N, control group without injection), 5, 15, 30 or 60 minutes they were decapitate and blood was...
Tipo: Estudos fisiológicos Palavras-chave: 2.00.00.00-6 sex differences; Nociception; Stress; Hormones; Rats 2.07.00.00-8.
Ano: 2012 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/10568
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Effect of repeated stress on novelty-induced antinociception in rats BJMBR
Torres,I.L.S.; Vasconcellos,A.P.; Silveira Cucco,S.N.; Dalmaz,C..
There is extensive evidence that acute stress induces an analgesic response in rats. On the other hand, repeatedly stressed animals may present the opposite effect, i.e., hyperalgesia. Furthermore, exposure to novelty is known to induce antinociception. The effects of repeated restraint stress on nociception after exposure to novelty, as measured by the tail-flick latency (TFL), were studied in adult male rats. The animals were stressed by restraint 1 h daily, 5 days a week for 40 days. The control group was not submitted to restraint. Nociception was assessed with a tail-flick apparatus. After being familiarized with the TFL apparatus, each group was subdivided into two other groups, i.e., with or without novelty. Animals were subjected to the TFL...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Pain; Stress; Repeated stress; Nociception; Novelty.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200012
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The Antinociceptive Effect of the Leaves and Flowers Ethanolic Extracts of Tabebuia aurea (Silva Manso) Benth & Hook. F. ex S. Moore BABT
Silva,Suellen Maria Albuquerque da; Silva Neto,Geraldo José da; Nascimento,Ivenis Raphael Cavalcante do; Viana,Max Denisson Maurício; Lima,Alyne Almeida de; Bezerra,Pedro Henrique Simões; Bastos,Maria Lysete de Assis; Moreira,Magna Suzana Alexandre; Campesatto,Eliane Aparecida.
ABSTRACT In view of the traditional use of Tabebuia aurea for treating pain and inflammation, the antinociceptive pharmacological potential of T. aurea ethanolic extracts (TAEE) was investigated through in vivo experimental models. First, the MTT assay was conducted to determine the potential cytotoxicity of the TAEEs. Afterwards, the acetic acid-induced writhing test and the formalin-, and glutamate-induced nociception tests were performed on Swiss adult mice treated with TAEEs (100 and 200 mg/kg doses, p.o.), or saline solution (control groups, 10mL/kg, p.o.), or standard drugs: dipyrone 40 mg/kg (p.o.), and morphine 5,7 mg/kg (i.p). In the MTT assay, none of the tested concentrations demonstrated signals of cytotoxicity. In the in vivo experimental...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Analgesics; Nociception; Medicinal plants; Tabebuia aurea; Mice.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100443
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The terrestrial Gastropoda Megalobulimus abbreviatus as a useful model for nociceptive experiments: effects of morphine and naloxone on thermal avoidance behavior BJMBR
Achaval,M.; Penha,M.A.P.; Swarowsky,A.; Rigon,P.; Xavier,L.L.; Viola,G.G.; Zancan,D.M..
We describe the behavior of the snail Megalobulimus abbreviatus upon receiving thermal stimuli and the effects of pretreatment with morphine and naloxone on behavior after a thermal stimulus, in order to establish a useful model for nociceptive experiments. Snails submitted to non-functional (22ºC) and non-thermal hot-plate stress (30ºC) only displayed exploratory behavior. However, the animals submitted to a thermal stimulus (50ºC) displayed biphasic avoidance behavior. Latency was measured from the time the animal was placed on the hot plate to the time when the animal lifted the head-foot complex 1 cm from the substrate, indicating aversive thermal behavior. Other animals were pretreated with morphine (5, 10, 20 mg/kg) or naloxone (2.5, 5.0, 7.5 mg/kg)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Snail; Thermal avoidance; Nociception; Morphine; Naloxone.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100012
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