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	Provedor de dados BJMBR (2) Autor Cao,J. (1) Chen,B. (1) Chu,Y.K. (1) Dong,R. (1) He,X.L. (1) Jin,D. (1) Lu,J.G. (1) Ma,Q.J. (1) Wang,Q. (1) Zhang,J. (1) Zheng,L. (1) Mais... Palavra-chave Nuclear factor kappa B (2) Antioxidant (1) E-cadherin (1) Epithelial-mesenchymal transition (1) Inflammation (1) Intermittent hypoxia (1) Obstructive sleep apnea (1) Reactive oxygen species (1) Snail (1) Tumor necrosis factor-a (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Inflammation induced by increased frequency of intermittent hypoxia is attenuated by tempol administration BJMBR Zhang,J.; Zheng,L.; Cao,J.; Chen,B.; Jin,D.. The levels of serum inflammatory cytokines and the activation of nuclear factor kappa B (NF-κB) and hypoxia inducible factor-1α (HIF-1α) in heart tissues in response to different frequencies of intermittent hypoxia (IH) and the antioxidant tempol were evaluated. Wistar rats (64 males, 200-220 g) were randomly divided into 6 experimental groups and 2 control groups. Four groups were exposed to IH 10, 20, 30, or 40 times/h. The other 2 experimental groups were challenged with IH (30 times/h) plus tempol, either beginning on day 0 (IH30T0) or on day 29 (IH30T29). After 6 weeks of challenge, serum levels of tumor necrosis factor (TNF)-α, intracellular adhesion molecule (ICAM)-1, and interleukin-10 were measured, and western blot analysis was used to detect... Tipo: Info:eu-repo/semantics/article Palavras-chave: Obstructive sleep apnea; Intermittent hypoxia; Inflammation; Nuclear factor kappa B; Antioxidant. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201115 Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-a-induced epithelial-mesenchymal transition of MCF-7 cells BJMBR Dong,R.; Wang,Q.; He,X.L.; Chu,Y.K.; Lu,J.G.; Ma,Q.J.. The microenvironment of the tumor plays an important role in facilitating cancer progression and activating dormant cancer cells. Most tumors are infiltrated with inflammatory cells which secrete cytokines such as tumor necrosis factor-a (TNF-a). To evaluate the role of TNF-a in the development of cancer we studied its effects on cell migration with a migration assay. The migrating cell number in TNF-a -treated group is about 2-fold of that of the control group. Accordingly, the expression of E-cadherin was decreased and the expression of vimentin was increased upon TNF-a treatment. These results showed that TNF-a can promote epithelial-mesenchymal transition (EMT) of MCF-7 cells. Further, we found that the expression of Snail, an important transcription... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tumor necrosis factor-a; Nuclear factor kappa B; Reactive oxygen species; Snail; E-cadherin; Epithelial-mesenchymal transition. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800007 Registros recuperados: 2 Primeira ... 1 ... Última

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